B0272.3 putative 3-hydroxyacyl-CoA dehydrogenase B0272.3 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: B0272.3
Gene description: putative 3-hydroxyacyl-CoA dehydrogenase B0272.3
Primary source: WormBase:WBGene00007129
Locus tag: CELE_B0272.3
See related: AllianceGenome:WB:WBGene00007129
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable 3-hydroxyacyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in several structures, including intestine; nervous system; non-striated muscle; pharynx; and seam cell. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 4. Orthologous to human HADH (hydroxyacyl-CoA dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See B0272.3 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 4

Sequence:: Chromosome: X; NC_003284.9 (9431432..9432745)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0272.3 (e-PCR)
- UniSTS:308838

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 3-hydroxyacyl-CoA dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3-hydroxyacyl-CoA dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables NAD+ binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid beta-oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid beta-oxidation	IEA Inferred from Electronic Annotation more info
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative 3-hydroxyacyl-CoA dehydrogenase B0272.3

NP_509584.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

9431432..9432745

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077183.8 → NP_509584.1 putative 3-hydroxyacyl-CoA dehydrogenase B0272.3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509584.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P41938

Conserved Domains (3) summary

COG1250
Location:20 → 308

FadB; 3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]

pfam00725
Location:211 → 308

3HCDH; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain

pfam02737
Location:24 → 209

3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain