U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Y39G8B.1 NADP-dependent oxidoreductase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175047, updated on 12-Jun-2024

    Summary

    Gene symbol
    Y39G8B.1
    Gene description
    NADP-dependent oxidoreductase domain-containing protein
    Locus tag
    CELE_Y39G8B.1
    See related
    AllianceGenome:WB:WBGene00012722
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable alditol:NADP+ 1-oxidoreductase activity. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in several diseases, including 46,XY sex reversal 8; congenital bile acid synthesis defect 2; diabetic neuropathy; leukemia (multiple); and type 2 diabetes mellitus. Orthologous to several human genes including AKR1A1 (aldo-keto reductase family 1 member A1). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Y39G8B.1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (13970580..13973812, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Serpentine Receptor, class E (Epsilon) Neighboring gene NADP-dependent oxidoreductase domain-containing protein Neighboring gene ncRNA Neighboring gene Serpentine Receptor, class E (Epsilon)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables aldose reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    NADP-dependent oxidoreductase domain-containing protein
    NP_001370070.1
    • Confirmed by transcript evidence
    NP_496924.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      13970580..13973812 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064523.3NP_496924.1  NADP-dependent oxidoreductase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496924.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U2J6
      Conserved Domains (1) summary
      cl00470
      Location:7301
      AKR_SF; Aldo-keto reductase (AKR) superfamily
    2. NM_001383987.1NP_001370070.1  NADP-dependent oxidoreductase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NAI5
      Conserved Domains (1) summary
      cl00470
      Location:7305
      AKR_SF; Aldo-keto reductase (AKR) superfamily