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    C49C8.5 Fibrinogen C-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177668, updated on 12-Jun-2024

    Summary

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    Gene symbol
    C49C8.5
    Gene description
    Fibrinogen C-terminal domain-containing protein
    Locus tag
    CELE_C49C8.5
    See related
    AllianceGenome:WB:WBGene00016769
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in innate immune response. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in intestine. Human ortholog(s) of this gene implicated in brain small vessel disease; congenital afibrinogenemia; and multiple myeloma. Orthologous to human ANGPTL1 (angiopoietin like 1); ANGPTL2 (angiopoietin like 2); and FGG (fibrinogen gamma chain). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See C49C8.5 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    12
    Sequence:
    Chromosome: IV; NC_003282.8 (8648666..8653664, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene HTH CENPB-type domain-containing protein Neighboring gene CYtochrome P450 family Neighboring gene ncRNA Neighboring gene TMhelix containing protein Neighboring gene Rx_N domain-containing protein Neighboring gene Protein kinase domain-containing protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Shapira M, et al. Proc Natl Acad Sci U S A, 2006 Sep 19. PMID 16968778, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in innate immune response HEP PubMed 
    Component Evidence Code Pubs
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Fibrinogen C-terminal domain-containing protein
    NP_501481.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      8648666..8653664 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069080.7 → NP_501481.2  Fibrinogen C-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501481.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18705
      Conserved Domains (1) summary
      cl00085
      Location:190 → 437
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    Nucleotide Protein
    Heading Accession and Version

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