SYT7 synaptotagmin 7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SYT7provided by HGNC
Official Full Name: synaptotagmin 7provided by HGNC
Primary source: HGNC:HGNC:11514
See related: Ensembl:ENSG00000011347 MIM:604146; AllianceGenome:HGNC:11514
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IPCA7; IPCA-7; SYTVII; PCANAP7; SYT-VII
Summary: This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. A similar protein in rodents mediates hormone secretion and lysosome exocytosis. In humans, expression of this gene has been associated with prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Expression: Biased expression in brain (RPKM 15.4), prostate (RPKM 13.8) and 12 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q12.2

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (61513714..61588387, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (61502594..61577283, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (61281186..61348548, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SYT7 is a key player in increasing exosome secretion and promoting angiogenesis in non-small-cell lung cancer.
Title: SYT7 is a key player in increasing exosome secretion and promoting angiogenesis in non-small-cell lung cancer.
SYT7 plays a role in promoting thyroid cancer by mediating HMGB3 ubiquitination.
Title: SYT7 plays a role in promoting thyroid cancer by mediating HMGB3 ubiquitination.
Syt-7 overexpression predicts poor prognosis and promotes cell proliferation in hepatocellular carcinoma.
Title: Syt-7 overexpression predicts poor prognosis and promotes cell proliferation in hepatocellular carcinoma.
High SYT7 expression is associated with poor prognosis in human non-small cell lung carcinoma.
Title: High SYT7 expression is associated with poor prognosis in human non-small cell lung carcinoma.
Synaptotagmin-7 deficiency induces mania-like behavioral abnormalities through attenuating GluN2B activity.
Title: Synaptotagmin-7 deficiency induces mania-like behavioral abnormalities through attenuating GluN2B activity.
Silencing of synaptotagmin 7 regulates osteosarcoma cell proliferation, apoptosis, and migration.
Title: Silencing of synaptotagmin 7 regulates osteosarcoma cell proliferation, apoptosis, and migration.
The Syt7 mRNA level was significantly attenuated in the bipolar disorder patient plasma compared to the healthy controls.
Title: Synaptotagmin-7 is a key factor for bipolar-like behavioral abnormalities in mice.
Membrane-Binding Cooperativity and Coinsertion by C2AB Tandem Domains of Synaptotagmins 1 and 7
Title: Membrane-Binding Cooperativity and Coinsertion by C2AB Tandem Domains of Synaptotagmins 1 and 7.
The oncogenic role of SYT7 in lung cancer.the oncogenic roles of SYT7 in lung cancer.SYT7 interacts with P53 and to potentiate the interaction between P53 and MDM2.
Title: Synaptotagmin-7, a binding protein of P53, inhibits the senescence and promotes the tumorigenicity of lung cancer cells.
Transcriptome data identified the overexpression of synaptotagmin VII (SYT7) in gastric cancer tissues with hepatic metastasis
Title: SYT7 acts as a driver of hepatic metastasis formation of gastric cancer cells.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-R71085 (e-PCR)
- UniSTS:518

A007K14 (e-PCR)
- UniSTS:49723

NoName (e-PCR)
- UniSTS:489540

D11S3034 (e-PCR)
- UniSTS:152136

Syt7 (e-PCR), detects polymorphism
- UniSTS:507266

RH47105 (e-PCR)
- UniSTS:49032

D11S4425 (e-PCR)
- UniSTS:3221

D11S2270E (e-PCR)
- UniSTS:24014

SYT7_8889 (e-PCR)
- UniSTS:467929

D11S2224E (e-PCR)
- UniSTS:473320

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium-dependent phospholipid binding	NAS Non-traceable Author Statement more info	PubMed
enables calmodulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables clathrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylserine binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables syntaxin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium ion regulated lysosome exocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium ion-regulated exocytosis of neurotransmitter	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion-regulated exocytosis of neurotransmitter	ISS Inferred from Sequence or Structural Similarity more info
involved_in phagocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in phagosome-lysosome fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in plasma membrane repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of calcium ion-dependent exocytosis	IEA Inferred from Electronic Annotation more info
involved_in regulation of bone remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of glucagon secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of insulin secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of phagocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synaptic vesicle endocytosis	IEA Inferred from Electronic Annotation more info
involved_in short-term synaptic potentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in synaptic vesicle recycling	ISS Inferred from Sequence or Structural Similarity more info
involved_in vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated cholesterol transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in dense core granule	IEA Inferred from Electronic Annotation more info
located_in early phagosome	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular exosome	HDA more info	PubMed
located_in hippocampal mossy fiber to CA3 synapse	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
located_in peroxisomal membrane	IEA Inferred from Electronic Annotation more info
located_in peroxisome	ISS Inferred from Sequence or Structural Similarity more info
located_in phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: synaptotagmin-7

Names: prostate cancer-associated protein 7; synaptotagmin VII

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252065.2 → NP_001238994.1 synaptotagmin-7 isoform 1

See identical proteins and their annotated locations for NP_001238994.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AP002754, AP003108, BC042495, BC125171, BE644642, BM675410, BQ447018

Consensus CDS

CCDS58139.1

UniProtKB/Swiss-Prot

O43581

Related

ENSP00000444201.1, ENST00000540677.5

Conserved Domains (2) summary

cd08386
Location:210 → 334

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:342 → 477

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
NM_001300773.2 → NP_001287702.1 synaptotagmin-7 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains an alternate in-frame exon in place of another alternate in-frame exon compared to variant 1. The resulting isoform (3) has an alternate 44 aa internal segment in place of an alternate 75 aa internal segment compared to isoform 1.

Source sequence(s)

AP002754, AP003108, BC042495, BC125170, BE644642, BQ447018, CA868518

Consensus CDS

CCDS73298.1

UniProtKB/Swiss-Prot

O43581

Related

ENSP00000444568.1, ENST00000542836.5

Conserved Domains (2) summary

cd08386
Location:179 → 303

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:311 → 446

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
NM_001365809.2 → NP_001352738.1 synaptotagmin-7 isoform 4

Status: REVIEWED

Source sequence(s)

AP002754, AP003108, AP003559

Consensus CDS

CCDS91487.1

Related

ENSP00000439694.1, ENST00000539008.6

Conserved Domains (3) summary

cd08386
Location:418 → 542

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:550 → 685

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7

PHA03307
Location:143 → 310

PHA03307; transcriptional regulator ICP4; Provisional
NM_001370210.1 → NP_001357139.1 synaptotagmin-7 isoform 5

Status: REVIEWED

Source sequence(s)

AP003108, AP003559

Conserved Domains (2) summary

cd08386
Location:231 → 355

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cl14603
Location:363 → 466

C2; C2 domain
NM_001370211.1 → NP_001357140.1 synaptotagmin-7 isoform 6

Status: REVIEWED

Source sequence(s)

AP002754, AP003108, AP003559

Conserved Domains (2) summary

cd08386
Location:135 → 259

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cl14603
Location:267 → 370

C2; C2 domain
NM_001411007.1 → NP_001397936.1 synaptotagmin-7 isoform 7

Status: REVIEWED

Source sequence(s)

AP002754, AP003108, AP003559

Consensus CDS

CCDS91486.1

Related

ENSP00000437720.1, ENST00000535826.5
NM_004200.4 → NP_004191.2 synaptotagmin-7 isoform 2

See identical proteins and their annotated locations for NP_004191.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an exon in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AP002754, AP003108, BC042495, BC125170, BE644642, BM675410, BQ447018

Consensus CDS

CCDS31577.1

UniProtKB/Swiss-Prot

F5GZC2, F5GZU9, F5H126, F5H1N2, F5H6C1, O43581, Q08AH6

Related

ENSP00000263846.4, ENST00000263846.8

Conserved Domains (2) summary

cd08386
Location:135 → 259

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:267 → 402

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

61513714..61588387 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011545343.3 → XP_011543645.1 synaptotagmin-7 isoform X12

Conserved Domains (2) summary

cd08386
Location:141 → 265

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:273 → 408

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
XM_011545340.3 → XP_011543642.1 synaptotagmin-7 isoform X8

Conserved Domains (2) summary

cd08386
Location:216 → 340

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:348 → 483

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
XM_011545337.3 → XP_011543639.1 synaptotagmin-7 isoform X3

Conserved Domains (2) summary

cd08386
Location:380 → 504

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:512 → 647

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
XM_011545341.3 → XP_011543643.1 synaptotagmin-7 isoform X9

Conserved Domains (2) summary

cd08386
Location:185 → 309

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:317 → 452

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
XM_011545338.3 → XP_011543640.1 synaptotagmin-7 isoform X5

Conserved Domains (2) summary

cd08386
Location:349 → 473

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:481 → 616

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
XM_011545339.3 → XP_011543641.1 synaptotagmin-7 isoform X7

Conserved Domains (2) summary

cd08386
Location:260 → 384

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:392 → 527

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
XM_011545336.3 → XP_011543638.1 synaptotagmin-7 isoform X2

Conserved Domains (2) summary

cd08386
Location:383 → 507

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:515 → 650

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
XM_011545335.3 → XP_011543637.1 synaptotagmin-7 isoform X1

Conserved Domains (2) summary

cd08386
Location:424 → 548

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:556 → 691

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
XM_005274384.3 → XP_005274441.1 synaptotagmin-7 isoform X4

Conserved Domains (3) summary

cd08386
Location:374 → 498

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:506 → 641

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7

PHA03307
Location:99 → 266

PHA03307; transcriptional regulator ICP4; Provisional
XM_005274385.5 → XP_005274442.1 synaptotagmin-7 isoform X6

UniProtKB/Swiss-Prot

O43581

Related

ENSP00000444019.1, ENST00000542670.5

Conserved Domains (2) summary

cd08386
Location:343 → 467

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:475 → 610

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
XM_005274387.5 → XP_005274444.1 synaptotagmin-7 isoform X10

Conserved Domains (2) summary

cd08386
Location:181 → 305

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:313 → 448

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
XM_011545342.3 → XP_011543644.1 synaptotagmin-7 isoform X11