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    Rnf167 ring finger protein 167 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360554, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Rnf167provided by RGD
    Official Full Name
    ring finger protein 167provided by RGD
    Primary source
    RGD:1305972
    See related
    Ensembl:ENSRNOG00000003879 AllianceGenome:RGD:1305972
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305972
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in negative regulation of cell cycle; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in endomembrane system. Predicted to be integral component of membrane. Predicted to be active in cytoplasm. Orthologous to human RNF167 (ring finger protein 167). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 358.0), Spleen (RPKM 279.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    10q24
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (55859254..55863546)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (55360603..55364927)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (57268331..57272667)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene glycoprotein Ib platelet subunit alpha Neighboring gene ribosomal protein L36A, pseudogene 2 Neighboring gene solute carrier family 25 member 11 Neighboring gene profilin 1 Neighboring gene enolase 3 Neighboring gene sperm associated antigen 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105. Yamada HY, et al. Oncogene, 2006 Mar 2. PMID 16314844, Free PMC Article
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94514

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to leucine starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to leucine starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of lysosome localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lysosome localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of lysosome localization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of TORC1 signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in organelle localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K29-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synaptic transmission, glutamatergic ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endolysosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endolysosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF167
    Names
    RING-type E3 ubiquitin transferase RNF167
    NP_001008362.1
    XP_006246812.1
    XP_038942250.1
    XP_063125409.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008361.1 → NP_001008362.1  E3 ubiquitin-protein ligase RNF167 precursor

      See identical proteins and their annotated locations for NP_001008362.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083670
      UniProtKB/Swiss-Prot
      Q5XIL0
      UniProtKB/TrEMBL
      A6HG77, A6HG78
      Related
      ENSRNOP00000005242.4, ENSRNOT00000005242.5
      Conserved Domains (2) summary
      cd02123
      Location:20 → 170
      PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
      cd16797
      Location:228 → 273
      RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      55859254..55863546
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246750.5 → XP_006246812.1  E3 ubiquitin-protein ligase RNF167 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AG57
      Related
      ENSRNOP00000087224.1
      Conserved Domains (2) summary
      cd02123
      Location:1 → 135
      PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
      cd16797
      Location:193 → 238
      RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

    2. XM_039086322.2 → XP_038942250.1  E3 ubiquitin-protein ligase RNF167 isoform X2

      UniProtKB/TrEMBL
      A6HG79
      Conserved Domains (3) summary
      cd00162
      Location:109 → 150
      RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]
      cl28883
      Location:1 → 49
      PA; Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain. At ...
      cl17238
      Location:107 → 152
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    3. XM_063269339.1 → XP_063125409.1  E3 ubiquitin-protein ligase RNF167 isoform X2

      UniProtKB/TrEMBL
      A6HG79
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIL0.1 GenPept UniProtKB/Swiss-Prot:Q5XIL0

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