HAE Leucine-rich receptor-like protein kinase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: HAE
Gene description: Leucine-rich receptor-like protein kinase family protein
Primary source: Araport:AT4G28490
Locus tag: AT4G28490
See related: TAIR:AT4G28490
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F20O9.180; F20O9_180; HAESA; RECEPTOR-LIKE PROTEIN KINASE 5; RLK5
Summary: Member of Receptor kinase-like protein family. Controls the separation step of floral organ abscission.
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Genomic context

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See HAE in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 2

Sequence:: Chromosome: 4; NC_003075.7 (14077676..14081457)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HAE role in the pectin degradation and resistance to Pseudomonas syringae in Arabidopsis leaves.
Title: IDL6-HAE/HSL2 impacts pectin degradation and resistance to Pseudomonas syringae pv tomato DC3000 in Arabidopsis leaves.
The HAESA co-receptor SERK1, a positive regulator of the floral abscission pathway, allows for high-affinity sensing of the peptide hormone by binding to an Arg-His-Asn motif in IDA.
Title: Mechanistic insight into a peptide hormone signaling complex mediating floral organ abscission.
The study reveals the signaling activation mechanism in floral organ abscission by IDA-induced HAE/HSL2-SERK complex formation accompanied by transphosphorylation.
Title: Ligand-Induced Receptor-like Kinase Complex Regulates Floral Organ Abscission in Arabidopsis.
Results provide evidence for a conserved phosphorylation site on a known activation domain additionally to another putative activation segment phosphorylation site that potentially modulates HAE activity and substrate specificity.
Title: Analysis of Phosphorylation of the Receptor-Like Protein Kinase HAESA during Arabidopsis Floral Abscission.
HAE HSL2-dependent and HAE HSL2-independent changes in genes expression are required for abscission
Title: Transcriptional profiling of the Arabidopsis abscission mutant hae hsl2 by RNA-Seq.
Floral organ abscission peptide IDA and its HAE/HSL2 receptors control cell separation during lateral root emergence.
Title: Floral organ abscission peptide IDA and its HAE/HSL2 receptors control cell separation during lateral root emergence.
Data show that through the receptor-like kinases HAESA and HAESA-LIKE2, IDA and the IDL proteins constitute a family of putative ligands to regulate different events during plant development.
Title: The EPIP peptide of INFLORESCENCE DEFICIENT IN ABSCISSION is sufficient to induce abscission in arabidopsis through the receptor-like kinases HAESA and HAESA-LIKE2.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_118991.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within floral organ abscission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lateral root morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within leaf abscission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pectin catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Leucine-rich receptor-like protein kinase family protein

NP_194578.1

HAESA (HAE); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: HAESA-like 1 (TAIR:AT1G28440.1); Has 220102 Blast hits to 139812 proteins in 4767 species: Archae - 153; Bacteria - 21531; Metazoa - 69757; Fungi - 11264; Plants - 91233; Viruses - 407; Other Eukaryotes - 25757 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

14077676..14081457

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_118991.3 → NP_194578.1 Leucine-rich receptor-like protein kinase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_194578.1

Status: REVIEWED

UniProtKB/Swiss-Prot

C0LGR4, P47735

UniProtKB/TrEMBL

A0A178UZW4

Conserved Domains (4) summary

PLN00113
Location:32 → 968

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:91 → 115

LRR_RI; leucine-rich repeat [structural motif]

pfam08263
Location:21 → 62

LRRNT_2; Leucine rich repeat N-terminal domain

cl21453
Location:689 → 967

PKc_like; Protein Kinases, catalytic domain