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    PLA2G5 phospholipase A2 group V [ Homo sapiens (human) ]

    Gene ID: 5322, updated on 3-Apr-2024

    Summary

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    Official Symbol
    PLA2G5provided by HGNC
    Official Full Name
    phospholipase A2 group Vprovided by HGNC
    Primary source
    HGNC:HGNC:9038
    See related
    Ensembl:ENSG00000127472 MIM:601192; AllianceGenome:HGNC:9038
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FRFB; GV-PLA2; PLA2-10; hVPLA(2)
    Summary
    This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in heart (RPKM 14.5), ovary (RPKM 8.6) and 8 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    1p36.13
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (20028408..20091911)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (19852033..19915547)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (20396687..20418404)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:20304755-20305254 Neighboring gene RNA, 7SL, cytoplasmic 304, pseudogene Neighboring gene phospholipase A2 group IIA Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_1574 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:20316184-20316758 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:20316759-20317334 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_1580 Neighboring gene prenylcysteine oxidase 1 pseudogene Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_1609 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_1624 Neighboring gene Sharpr-MPRA regulatory region 6877 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_1646 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_1651 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 310 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 311 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 312 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_1658 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_1659 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_1661 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_1663 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_1667 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 313 Neighboring gene phospholipase A2 group IID Neighboring gene ATAC-STARR-seq lymphoblastoid active region 314 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 315 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:20468424-20468924 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:20474795-20475295 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:20476004-20476630 Neighboring gene phospholipase A2 group IIF

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Epigenetic control of group V phospholipase A2 expression in human malignant cells. Menschikowski M, et al. Tumour Biol, 2016 Jun. PMID 26715269
    2. Phospholipase A2 group v in benign familial fleck retina in a set of triplets. Bin NJ, et al. Retina, 2015 Jun. PMID 25549071
    3. The (G>A) rs11573191 polymorphism of PLA2G5 gene is associated with premature coronary artery disease in the Mexican Mestizo population: the genetics of atherosclerotic disease Mexican study. Vargas-Alarcón G, et al. Biomed Res Int, 2014. PMID 24959594, Free PMC Article
    4. Novel genetic approach to investigate the role of plasma secretory phospholipase A2 (sPLA2)-V isoenzyme in coronary heart disease: modified Mendelian randomization analysis using PLA2G5 expression levels. Holmes MV, et al. Circ Cardiovasc Genet, 2014 Apr. PMID 24563418, Free PMC Article
    5. Biallelic mutations in PLA2G5, encoding group V phospholipase A2, cause benign fleck retina. Sergouniotis PI, et al. Am J Hum Genet, 2011 Dec 9. PMID 22137173, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lipid Profile of Activated Macrophages and Contribution of Group V Phospholipase A2.
      Title: Lipid Profile of Activated Macrophages and Contribution of Group V Phospholipase A(2).
    2. Lysosome-mediated autophagy pathway contributes to gVPLA2 clearance from lung endothelial cells.
      Title: Degradation of group V secretory phospholipase A(2) in lung endothelium is mediated by autophagy.
    3. This report provides the first demonstration that Phosphatidylcholine-Isoprostanes are readily hydrolyzed by group IIA, V and X Secretory Phospholipases A2.
      Title: Hydrolysis of Phosphatidylcholine-Isoprostanes (PtdCho-IP) by Peripheral Human Group IIA, V and X Secretory Phospholipases A(2) (sPLA(2)).
    4. Low GV-PLA2 expression is associated with cancer.
      Title: Epigenetic control of group V phospholipase A2 expression in human malignant cells.
    5. Data show that phospholipase A2 group IIA, V and X have different target/function related activity.
      Title: Hydrolysis of lipoproteins by sPLA2's enhances mitogenesis and eicosanoid release from vascular smooth muscle cells: Diverse activity of sPLA2's IIA, V and X.
    6. The clinical findings in this family suggest a diagnosis of benign familial fleck retina with excellent prognosis, in which the PLA2G5 gene may play a role.
      Title: Phospholipase A2 group v in benign familial fleck retina in a set of triplets.
    7. sPLA2-V plays a thrombogenic role by impairing the ability of EPCR to promote protein C activation.
      Title: Group V secretory phospholipase A2 impairs endothelial protein C receptor-dependent protein C activation and accelerates thrombosis in vivo.
    8. results demonstrate that EPCR is overexpressed and mediates the aggressive behavior of rheumatoid synovial fibroblasts, and is likely driven by group V secretory phospholipase A2
      Title: Endothelial protein C receptor-associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A2.
    9. expression of PLA2s-IIE and -V correlates with the development of calcification as well as the expression of pro-osteogenic molecules in human aortic valves
      Title: The expression of groups IIE and V phospholipase A2 is associated with an increased expression of osteogenic molecules in human calcified aortic valves.
    10. Summarizing, Der p1 and Fel d1 involve phospholipase A2 enzymes in their action.
      Title: The step further to understand the role of cytosolic phospholipase A2 alpha and group X secretory phospholipase A2 in allergic inflammation: pilot study.
    Submit: New GeneRIF Correction See all GeneRIFs (31)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Familial benign flecked retina
    MedGen: C1856718 OMIM: 228980 GeneReviews: Not available
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed
    env HIV-1 gp120 induces a specific phospholipase A2 (PLA2) activation in lymphocytes through binding to CD4, but this effect is not sufficient to accomplish virus/cell fusion PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC46205, DKFZp686C2294

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-independent phospholipase A2 activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in arachidonic acid secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cardiolipin acyl-chain remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in leukotriene biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in low-density lipoprotein particle remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of T cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phagosome-lysosome fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phosphatidylcholine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phospholipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of antifungal innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of immune complex clearance by monocytes and macrophages IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of macrophage derived foam cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of opsonization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of phagocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of phagosome maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of phospholipase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early phagosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in phagolysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in recycling endosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phospholipase A2 group V
    Names
    Ca2+-dependent phospholipase A2
    calcium-dependent phospholipase A2
    phosphatidylcholine 2-acylhydrolase 5
    NP_000920.1
    XP_005245948.1
    XP_005245949.1
    XP_005245950.1
    XP_011539888.1
    XP_011539889.1
    XP_011539890.1
    XP_011539891.1
    XP_011539892.1
    XP_011539893.1
    XP_011539894.1
    XP_047278564.1
    XP_047278572.1
    XP_047278591.1
    XP_047278593.1
    XP_047278599.1
    XP_047278601.1
    XP_054193058.1
    XP_054193059.1
    XP_054193060.1
    XP_054193061.1
    XP_054193062.1
    XP_054193063.1
    XP_054193064.1
    XP_054193065.1
    XP_054193066.1
    XP_054193067.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032045.1 RefSeqGene

      Range
      4987..26704
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000929.3 → NP_000920.1  phospholipase A2 group V precursor

      See identical proteins and their annotated locations for NP_000920.1

      Status: REVIEWED

      Source sequence(s)
      AL158172, AV709457, BC036792, BM684907, BM705479
      Consensus CDS
      CCDS202.1
      UniProtKB/Swiss-Prot
      P39877, Q8N435
      UniProtKB/TrEMBL
      B3KUQ4
      Related
      ENSP00000364249.3, ENST00000375108.4
      Conserved Domains (1) summary
      cd00125
      Location:21 → 137
      PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      20028408..20091911
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047422608.1 → XP_047278564.1  phospholipase A2 group V isoform X1

    2. XM_047422616.1 → XP_047278572.1  phospholipase A2 group V isoform X1

    3. XM_047422645.1 → XP_047278601.1  phospholipase A2 group V isoform X2

      UniProtKB/Swiss-Prot
      P39877, Q8N435

    4. XM_005245891.6 → XP_005245948.1  phospholipase A2 group V isoform X1

      See identical proteins and their annotated locations for XP_005245948.1

      Conserved Domains (1) summary
      cd00125
      Location:52 → 168
      PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

    5. XM_047422635.1 → XP_047278591.1  phospholipase A2 group V isoform X2

      UniProtKB/Swiss-Prot
      P39877, Q8N435

    6. XM_011541589.4 → XP_011539891.1  phospholipase A2 group V isoform X2

      See identical proteins and their annotated locations for XP_011539891.1

      UniProtKB/Swiss-Prot
      P39877, Q8N435
      UniProtKB/TrEMBL
      B3KUQ4
      Conserved Domains (1) summary
      cd00125
      Location:21 → 137
      PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

    7. XM_047422637.1 → XP_047278593.1  phospholipase A2 group V isoform X2

      UniProtKB/Swiss-Prot
      P39877, Q8N435

    8. XM_011541587.4 → XP_011539889.1  phospholipase A2 group V isoform X2

      See identical proteins and their annotated locations for XP_011539889.1

      UniProtKB/Swiss-Prot
      P39877, Q8N435
      UniProtKB/TrEMBL
      B3KUQ4
      Conserved Domains (1) summary
      cd00125
      Location:21 → 137
      PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

    9. XM_011541588.4 → XP_011539890.1  phospholipase A2 group V isoform X2

      See identical proteins and their annotated locations for XP_011539890.1

      UniProtKB/Swiss-Prot
      P39877, Q8N435
      UniProtKB/TrEMBL
      B3KUQ4
      Conserved Domains (1) summary
      cd00125
      Location:21 → 137
      PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

    10. XM_005245893.6 → XP_005245950.1  phospholipase A2 group V isoform X2

      See identical proteins and their annotated locations for XP_005245950.1

      UniProtKB/Swiss-Prot
      P39877, Q8N435
      UniProtKB/TrEMBL
      B3KUQ4
      Conserved Domains (1) summary
      cd00125
      Location:21 → 137
      PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

    11. XM_011541590.4 → XP_011539892.1  phospholipase A2 group V isoform X2

      See identical proteins and their annotated locations for XP_011539892.1

      UniProtKB/Swiss-Prot
      P39877, Q8N435
      UniProtKB/TrEMBL
      B3KUQ4
      Conserved Domains (1) summary
      cd00125
      Location:21 → 137
      PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

    12. XM_005245892.6 → XP_005245949.1  phospholipase A2 group V isoform X1

      See identical proteins and their annotated locations for XP_005245949.1

      Conserved Domains (1) summary
      cd00125
      Location:52 → 168
      PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

    13. XM_047422643.1 → XP_047278599.1  phospholipase A2 group V isoform X2

      UniProtKB/Swiss-Prot
      P39877, Q8N435

    14. XM_011541591.4 → XP_011539893.1  phospholipase A2 group V isoform X2

      See identical proteins and their annotated locations for XP_011539893.1

      UniProtKB/Swiss-Prot
      P39877, Q8N435
      UniProtKB/TrEMBL
      B3KUQ4
      Conserved Domains (1) summary
      cd00125
      Location:21 → 137
      PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

    15. XM_011541586.4 → XP_011539888.1  phospholipase A2 group V isoform X1

      See identical proteins and their annotated locations for XP_011539888.1

      Conserved Domains (1) summary
      cd00125
      Location:52 → 168
      PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

    16. XM_011541592.4 → XP_011539894.1  phospholipase A2 group V isoform X2

      See identical proteins and their annotated locations for XP_011539894.1

      UniProtKB/Swiss-Prot
      P39877, Q8N435
      UniProtKB/TrEMBL
      B3KUQ4
      Conserved Domains (1) summary
      cd00125
      Location:21 → 137
      PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      19852033..19915547
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337089.1 → XP_054193064.1  phospholipase A2 group V isoform X2

      UniProtKB/Swiss-Prot
      P39877, Q8N435

    2. XM_054337087.1 → XP_054193062.1  phospholipase A2 group V isoform X2

      UniProtKB/Swiss-Prot
      P39877, Q8N435

    3. XM_054337088.1 → XP_054193063.1  phospholipase A2 group V isoform X2

      UniProtKB/Swiss-Prot
      P39877, Q8N435

    4. XM_054337090.1 → XP_054193065.1  phospholipase A2 group V isoform X2

      UniProtKB/Swiss-Prot
      P39877, Q8N435

    5. XM_054337091.1 → XP_054193066.1  phospholipase A2 group V isoform X2

      UniProtKB/Swiss-Prot
      P39877, Q8N435

    6. XM_054337092.1 → XP_054193067.1  phospholipase A2 group V isoform X2

      UniProtKB/Swiss-Prot
      P39877, Q8N435

    7. XM_054337084.1 → XP_054193059.1  phospholipase A2 group V isoform X1

    8. XM_054337083.1 → XP_054193058.1  phospholipase A2 group V isoform X1

    9. XM_054337085.1 → XP_054193060.1  phospholipase A2 group V isoform X1

    10. XM_054337086.1 → XP_054193061.1  phospholipase A2 group V isoform X2

      UniProtKB/Swiss-Prot
      P39877, Q8N435
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39877.1 GenPept UniProtKB/Swiss-Prot:P39877

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