Apobec2 apolipoprotein B mRNA editing enzyme catalytic subunit 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Apobec2provided by RGD
Official Full Name: apolipoprotein B mRNA editing enzyme catalytic subunit 2provided by RGD
Primary source: RGD:1308727
See related: Ensembl:ENSRNOG00000012303 AllianceGenome:RGD:1308727
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable RNA binding activity; cytidine deaminase activity; and identical protein binding activity. Predicted to be involved in DNA demethylation and cytidine to uridine editing. Predicted to act upstream of or within mRNA modification. Predicted to be active in cytoplasm and nucleus. Orthologous to human APOBEC2 (apolipoprotein B mRNA editing enzyme catalytic subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 2212.8), Heart (RPKM 839.7) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 9q12

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (20062561..20076074)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (12564955..12578461)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (14529218..14542731)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH128292 (e-PCR)
- UniSTS:211600

RH128626 (e-PCR)
- UniSTS:211934

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytidine deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytidine deaminase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA demethylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytidine deamination	IEA Inferred from Electronic Annotation more info
involved_in cytidine to uridine editing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cytidine to uridine editing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mRNA modification	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression via chromosomal CpG island demethylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: C->U-editing enzyme APOBEC-2

Names: apolipoprotein B editing complex 2; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2; probable C->U-editing enzyme APOBEC-2

NP_001100353.1

EC 3.5.4.36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.