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    Klhl14 kelch-like family member 14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 364823, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Klhl14provided by RGD
    Official Full Name
    kelch-like family member 14provided by RGD
    Primary source
    RGD:1566178
    See related
    Ensembl:ENSRNOG00000015418 AllianceGenome:RGD:1566178
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1566178
    Summary
    Predicted to be located in actin cytoskeleton; aggresome; and cytosol. Predicted to be active in endoplasmic reticulum; neuron projection; and neuronal cell body. Orthologous to human KLHL14 (kelch like family member 14). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 50.9), Spleen (RPKM 25.8) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Klhl14 in Genome Data Viewer
    Location:
    18p12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (13079159..13192728, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (12804253..12917828, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (12526627..12640381, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098265 Neighboring gene GRB2 associated regulator of MAPK1 subtype 1 Neighboring gene U6 spliceosomal RNA Neighboring gene RIKEN cDNA 4930426D05 gene like Neighboring gene uncharacterized LOC134482977 Neighboring gene coiled-coil domain containing 178 Neighboring gene ASXL transcriptional regulator 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Printor, a novel torsinA-interacting protein implicated in dystonia pathogenesis. Giles LM, et al. J Biol Chem, 2009 Aug 7. PMID 19535332, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in aggresome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in aggresome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 14
    Names
    kelch-like 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108885.1 → NP_001102355.1  kelch-like protein 14

      See identical proteins and their annotated locations for NP_001102355.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473974
      UniProtKB/TrEMBL
      A0A2I4HY32, A0A5S6R9P2, A0A8I6APG0, A6J2H6, D3ZYQ7
      Related
      ENSRNOP00000020697.5, ENSRNOT00000020697.7
      Conserved Domains (4) summary
      PHA03098
      Location:140 → 602
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:365 → 412
      Kelch; KELCH repeat [structural motif]
      cd18243
      Location:1 → 190
      BTB_POZ_KLHL14_printor; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14)
      cd18453
      Location:183 → 284
      BACK_KLHL14; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      13079159..13192728 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096999.2 → XP_038952927.1  kelch-like protein 14 isoform X1

      UniProtKB/TrEMBL
      A0A2I4HY32, A0A5S6R9P2, A0A8I6APG0, A6J2H6, D3ZYQ7
      Conserved Domains (4) summary
      PHA03098
      Location:140 → 602
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:365 → 412
      Kelch; KELCH repeat [structural motif]
      cd18243
      Location:1 → 190
      BTB_POZ_KLHL14_printor; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14)
      cd18453
      Location:183 → 284
      BACK_KLHL14; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14)
    Nucleotide Protein Strain
    Heading Accession and Version

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