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    Kiaa1614 KIAA1614 homolog [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305101, updated on 13-Apr-2024

    Summary

    Official Symbol
    Kiaa1614provided by RGD
    Official Full Name
    KIAA1614 homologprovided by RGD
    Primary source
    RGD:1304622
    See related
    Ensembl:ENSRNOG00000000040 AllianceGenome:RGD:1304622
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304622
    Summary
    Predicted to enable protein kinase C binding activity. Predicted to be involved in centrosome cycle; establishment or maintenance of cell polarity; and regulation of cellular localization. Predicted to be active in apical plasma membrane; cell cortex; and nucleus. Orthologous to human KIAA1614 (KIAA1614). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 48.5), Heart (RPKM 23.4) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Kiaa1614 in Genome Data Viewer
    Location:
    13q21
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (69939228..69977703, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (67388916..67427392, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (72860313..72900020, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein uL29-like Neighboring gene syntaxin 6 Neighboring gene xenotropic and polytropic retrovirus receptor 1 Neighboring gene uncharacterized LOC102553685

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in centrosome cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in establishment or maintenance of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cellular localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    uncharacterized protein KIAA1614 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427644.1NP_001414573.1  uncharacterized protein KIAA1614 homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A1W2Q6M3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      69939228..69977703 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250087.5XP_006250149.1  uncharacterized protein KIAA1614 homolog isoform X2

      See identical proteins and their annotated locations for XP_006250149.1

      Conserved Domains (2) summary
      cd00992
      Location:10771158
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15737
      Location:313436
      DUF4685; Domain of unknown function (DUF4685)
    2. XM_006250088.5XP_006250150.1  uncharacterized protein KIAA1614 homolog isoform X3

      Conserved Domains (2) summary
      cd00992
      Location:10611142
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15737
      Location:343420
      DUF4685; Domain of unknown function (DUF4685)
    3. XM_017598985.3XP_017454474.1  uncharacterized protein KIAA1614 homolog isoform X1

    4. XM_039091362.1XP_038947290.1  uncharacterized protein KIAA1614 homolog isoform X5

      Conserved Domains (2) summary
      cd00992
      Location:739820
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15737
      Location:198
      DUF4685; Domain of unknown function (DUF4685)
    5. XM_039091363.1XP_038947291.1  uncharacterized protein KIAA1614 homolog isoform X6

      Conserved Domains (2) summary
      cd00992
      Location:674755
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15737
      Location:133
      DUF4685; Domain of unknown function (DUF4685)
    6. XM_017598990.3XP_017454479.1  uncharacterized protein KIAA1614 homolog isoform X5

      Conserved Domains (2) summary
      cd00992
      Location:739820
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15737
      Location:198
      DUF4685; Domain of unknown function (DUF4685)
    7. XM_006250090.5XP_006250152.1  uncharacterized protein KIAA1614 homolog isoform X4

      UniProtKB/TrEMBL
      A6ICY7
      Conserved Domains (1) summary
      pfam15737
      Location:345468
      DUF4685; Domain of unknown function (DUF4685)