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    Ttc7b tetratricopeptide repeat domain 7B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362768, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Ttc7bprovided by RGD
    Official Full Name
    tetratricopeptide repeat domain 7Bprovided by RGD
    Primary source
    RGD:1305920
    See related
    Ensembl:ENSRNOG00000027300 AllianceGenome:RGD:1305920
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in phosphatidylinositol phosphate biosynthetic process and protein localization to plasma membrane. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Orthologous to human TTC7B (tetratricopeptide repeat domain 7B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 211.9), Brain (RPKM 209.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ttc7b in Genome Data Viewer
    Location:
    6q32
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (125317011..125528843, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (119587389..119799167, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (124316444..124528058, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479248 Neighboring gene calmodulin 1 Neighboring gene ribosomal protein S6 kinase A5 Neighboring gene U6 spliceosomal RNA Neighboring gene polycomb group ring finger 5 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane. Baskin JM, et al. Nat Cell Biol, 2016 Jan. PMID 26571211, Free PMC Article
    2. PtdIns4P synthesis by PI4KIIIα at the plasma membrane and its impact on plasma membrane identity. Nakatsu F, et al. J Cell Biol, 2012 Dec 10. PMID 23229899, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tetratricopeptide repeat protein 7B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108719.3 → NP_001102189.2  tetratricopeptide repeat protein 7B isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A0G2JXJ6
      Related
      ENSRNOP00000070298.2, ENSRNOT00000080950.2

    2. NM_001401371.1 → NP_001388300.1  tetratricopeptide repeat protein 7B isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6A7F1
      Related
      ENSRNOP00000089503.1, ENSRNOT00000108767.1

    3. NM_001401373.1 → NP_001388302.1  tetratricopeptide repeat protein 7B isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AFJ5
      Related
      ENSRNOP00000091624.1, ENSRNOT00000099229.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      125317011..125528843 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112527.2 → XP_038968455.1  tetratricopeptide repeat protein 7B isoform X3

      Conserved Domains (4) summary
      TIGR00990
      Location:686 → 859
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      TIGR02917
      Location:343 → 851
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00008
      Location:431 → 459
      TPR_YbbN; TPR repeat [structural motif]
      sd00006
      Location:747 → 775
      TPR; TPR repeat [structural motif]

    2. XM_063262123.1 → XP_063118193.1  tetratricopeptide repeat protein 7B isoform X2

    3. XM_039112520.2 → XP_038968448.1  tetratricopeptide repeat protein 7B isoform X1

      Conserved Domains (4) summary
      COG0457
      Location:365 → 619
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      TIGR00990
      Location:757 → 930
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00008
      Location:431 → 459
      TPR_YbbN; TPR repeat [structural motif]
      sd00006
      Location:818 → 846
      TPR; TPR repeat [structural motif]

    4. XM_063262125.1 → XP_063118195.1  tetratricopeptide repeat protein 7B isoform X5

    5. XM_063262126.1 → XP_063118196.1  tetratricopeptide repeat protein 7B isoform X6

    6. XM_063262124.1 → XP_063118194.1  tetratricopeptide repeat protein 7B isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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