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    Ralgps2 Ral GEF with PH domain and SH3 binding motif 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304887, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Ralgps2provided by RGD
    Official Full Name
    Ral GEF with PH domain and SH3 binding motif 2provided by RGD
    Primary source
    RGD:1311537
    See related
    Ensembl:ENSRNOG00000004736 AllianceGenome:RGD:1311537
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of Ral protein signal transduction; regulation of catalytic activity; and small GTPase mediated signal transduction. Orthologous to human RALGPS2 (Ral GEF with PH domain and SH3 binding motif 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 753.7), Spleen (RPKM 285.0) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ralgps2 in Genome Data Viewer
    Location:
    13q22
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (71474835..71654791, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (68924674..69104637, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (74446001..74520640, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481575 Neighboring gene enolase 1 like 2 Neighboring gene angiopoietin-like 1 Neighboring gene C-type lectin domain containing 20A Neighboring gene testis expressed 35 Neighboring gene RAS protein activator like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The PH-PxxP domain of RalGPS2 promotes PC12 cells differentiation acting as a dominant negative for RalA GTPase activation. Ceriani M, et al. Neurosci Res, 2010 Mar. PMID 20025911
    2. Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral. Rebhun JF, et al. J Biol Chem, 2000 May 5. PMID 10747847
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ras-specific guanine nucleotide-releasing factor RalGPS2
    Names
    Ral-A exchange factor RalGPS2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100680.1 → NP_001094150.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform 2

      See identical proteins and their annotated locations for NP_001094150.1

      Status: VALIDATED

      Source sequence(s)
      BC105626
      UniProtKB/TrEMBL
      A6ID21, F1MAR5, Q0VGK1
      Conserved Domains (1) summary
      smart00147
      Location:45 → 286
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

    2. NM_001401396.1 → NP_001388325.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A0G2JTI5, A0A8I6GHG1
      Related
      ENSRNOP00000089573.1, ENSRNOT00000103744.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      71474835..71654791 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090756.2 → XP_038946684.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JTI5, A0A8I6GHG1
      Conserved Domains (2) summary
      smart00147
      Location:45 → 286
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd13310
      Location:459 → 574
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

    2. XM_063272338.1 → XP_063128408.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JTI5, A0A8J8XSQ7

    3. XM_039090753.2 → XP_038946681.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JTI5, A0A8I6GHG1
      Conserved Domains (2) summary
      smart00147
      Location:45 → 286
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd13310
      Location:459 → 574
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

    4. XM_039090758.2 → XP_038946686.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JTI5, A0A8J8XSQ7
      Related
      ENSRNOP00000033737.5
      Conserved Domains (2) summary
      smart00147
      Location:45 → 286
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd13310
      Location:433 → 548
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

    5. XM_063272340.1 → XP_063128410.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JTI5, A0A8J8XSQ7

    6. XM_039090755.2 → XP_038946683.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JTI5, A0A8I6GHG1
      Related
      ENSRNOP00000068725.2
      Conserved Domains (2) summary
      smart00147
      Location:45 → 286
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd13310
      Location:459 → 574
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

    7. XM_063272339.1 → XP_063128409.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JTI5, A0A8J8XSQ7

    8. XM_039090752.2 → XP_038946680.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JTI5, A0A8I6GHG1
      Conserved Domains (2) summary
      smart00147
      Location:45 → 286
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd13310
      Location:459 → 574
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

    9. XM_063272335.1 → XP_063128405.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JTI5, A0A8I6GHG1

    10. XM_063272336.1 → XP_063128406.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JTI5, A0A8J8XSQ7

    11. XM_063272341.1 → XP_063128411.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JTI5, A0A8J8XSQ7

    12. XM_063272334.1 → XP_063128404.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JTI5, A0A8I6GHG1

    13. XM_039090757.2 → XP_038946685.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JTI5, A0A8I6GHG1
      Conserved Domains (2) summary
      smart00147
      Location:45 → 286
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd13310
      Location:459 → 574
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

    14. XM_063272333.1 → XP_063128403.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JTI5, A0A8I6GHG1

    15. XM_039090761.2 → XP_038946689.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A8Z1
      Conserved Domains (2) summary
      cd13310
      Location:319 → 434
      PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
      cl02485
      Location:1 → 146
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    16. XM_063272342.1 → XP_063128412.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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