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    Pzp pregnancy-zone protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 252922, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Pzpprovided by RGD
    Official Full Name
    pregnancy-zone proteinprovided by RGD
    Primary source
    RGD:628643
    See related
    Ensembl:ENSRNOG00000006709 AllianceGenome:RGD:628643
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    A1m
    Summary
    Enables brain-derived neurotrophic factor binding activity and nerve growth factor binding activity. Predicted to be involved in embryo implantation and negative regulation of endopeptidase activity. Predicted to be located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 11089.4) See more
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    Genomic context

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    Location:
    4q42
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (163445265..163491358, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (161759176..161805271, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (161804792..161850877, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102402 Neighboring gene uncharacterized LOC102554670 Neighboring gene FKBP prolyl isomerase 4 Neighboring gene alpha-2-macroglobulin-like 1 Neighboring gene uncharacterized LOC102554736

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Alpha1-macroglobulin: a potential obesity-related factor in serum. Zhao D, et al. Med Sci Monit, 2008 Mar. PMID 18301350
    2. cDNA cloning and sequencing of rat alpha 1-macroglobulin. Wärmegård B, et al. Biochemistry, 1992 Mar 3. PMID 1371696
    3. Comparative binding of biotinylated neurotrophins to alpha(2)-macroglobulin family of proteins: relationship between cytokine-binding and neuro-modulatory activities of the macroglobulins. Skornicka EL, et al. J Neurosci Res, 2002 Feb 1. PMID 11813239
    4. Sequence of rat alpha 1-macroglobulin, a broad-range proteinase inhibitor from the alpha-macroglobulin-complement family. Eggertsen G, et al. Mol Biol Med, 1991 Apr. PMID 1725450
    5. ATP-activated, high-molecular-mass proteinase-I from rat skeletal muscle is a cysteine proteinase-alpha 1-macroglobulin complex. Dahlmann B, et al. Biochim Biophys Acta, 1989 May 31. PMID 2470410

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables brain-derived neurotrophic factor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nerve growth factor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protease binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryo implantation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-1-macroglobulin
    Names
    alpha-1-M
    alpha-1-macroglobulin 165 kDa subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145779.2 → NP_665722.2  alpha-1-macroglobulin precursor

      See identical proteins and their annotated locations for NP_665722.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q63041, Q63332
      UniProtKB/TrEMBL
      A0A8L2Q3W7, A6IM16
      Related
      ENSRNOP00000009467.5, ENSRNOT00000009467.7
      Conserved Domains (7) summary
      COG2373
      Location:127 → 1127
      YfaS; Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only]
      cd02897
      Location:972 → 1287
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:752 → 842
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:127 → 219
      A2M_N; MG2 domain
      pfam07677
      Location:1400 → 1487
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:1024 → 1289
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:460 → 605
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      163445265..163491358 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008763310.3 → XP_008761532.1  alpha-1-macroglobulin isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q3W7
      Conserved Domains (6) summary
      cd02897
      Location:961 → 1276
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:741 → 831
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:127 → 219
      A2M_N; MG2 domain
      pfam07677
      Location:1389 → 1476
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:1013 → 1278
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:460 → 605
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63041.1 GenPept UniProtKB/Swiss-Prot:Q63041

    Gene LinkOut

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