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    Usp2 ubiquitin specific peptidase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 115771, updated on 25-Apr-2024

    Summary

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    Official Symbol
    Usp2provided by RGD
    Official Full Name
    ubiquitin specific peptidase 2provided by RGD
    Primary source
    RGD:621073
    See related
    Ensembl:ENSRNOG00000006663 AllianceGenome:RGD:621073
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    UBP-t
    Summary
    Enables thiol-dependent deubiquitinase. Involved in negative regulation of skeletal muscle tissue development; positive regulation of skeletal muscle tissue development; and protein deubiquitination. Located in centrosome; nucleus; and perinuclear region of cytoplasm. Orthologous to human USP2 (ubiquitin specific peptidase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 196.5), Muscle (RPKM 120.0) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Usp2 in Genome Data Viewer
    Location:
    8q22
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (53308264..53336800)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (44411457..44439668)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (48403985..48432525)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480042 Neighboring gene Thy-1 cell surface antigen Neighboring gene membrane frizzled-related protein Neighboring gene C1q and TNF related 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Retigabine ameliorates acute stress-induced impairment of spatial memory retrieval through regulating USP2 signaling pathways in hippocampal CA1 area. Li C, et al. Neuropharmacology, 2018 Jun. PMID 29501527
    2. Antagonistic regulation of myogenesis by two deubiquitinating enzymes, UBP45 and UBP69. Park KC, et al. Proc Natl Acad Sci U S A, 2002 Jul 23. PMID 12107281, Free PMC Article
    3. Ubiquitin-specific protease 2-69 in macrophages potentially modulates metainflammation. Kitamura H, et al. FASEB J, 2013 Dec. PMID 24005904
    4. Divergent N-terminal sequences target an inducible testis deubiquitinating enzyme to distinct subcellular structures. Lin H, et al. Mol Cell Biol, 2000 Sep. PMID 10938131, Free PMC Article
    5. Suppression of cancer cell growth by promoting cyclin D1 degradation. Shan J, et al. Mol Cell, 2009 Nov 13. PMID 19917254, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ubiquitin-specific protease 2 regulates Ang -induced cardiac fibroblasts activation by up-regulating cyclin D1 and stabilizing beta-catenin in vitro.
      Title: Ubiquitin-specific protease 2 regulates Ang Ⅱ-induced cardiac fibroblasts activation by up-regulating cyclin D1 and stabilizing β-catenin in vitro.
    2. results have identified USP2 as a key molecule that mediates stress-induced spatial memory retrieval impairment.
      Title: Retigabine ameliorates acute stress-induced impairment of spatial memory retrieval through regulating USP2 signaling pathways in hippocampal CA1 area.
    3. myogenic differentiation of embryonic muscle cells is antagonistically regulated by two deubiquitinating enzymes, UBP45 and UBP69, that are generated by alternative splicing[Usp2].
      Title: Antagonistic regulation of myogenesis by two deubiquitinating enzymes, UBP45 and UBP69.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC93284

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cyclin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type deubiquitinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in circadian behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in circadian behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in circadian regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in circadian regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in entrainment of circadian clock by photoperiod ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in entrainment of circadian clock by photoperiod ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in locomotor rhythm ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in locomotor rhythm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in muscle organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of skeletal muscle tissue development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of skeletal muscle tissue development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rhythmic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 2
    Names
    41 kDa ubiquitin-specific protease
    deubiquitinating enzyme 2
    ubiquitin specific protease 2
    ubiquitin thioesterase 2
    ubiquitin thiolesterase 2
    ubiquitin-specific-processing protease 2
    ubiquitin-specific-processing protease testis
    NP_446226.3
    XP_006242925.1
    XP_008764360.1
    XP_008764361.1
    XP_038936630.1
    XP_038936631.1
    XP_038936632.1
    XP_063120846.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053774.3 → NP_446226.3  ubiquitin carboxyl-terminal hydrolase 2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q5U349, Q9QXL3, Q9QXL4, Q9R083, Q9R084
      UniProtKB/TrEMBL
      A0A8L2Q4I7
      Related
      ENSRNOP00000078529.1, ENSRNOT00000104911.1
      Conserved Domains (1) summary
      pfam00443
      Location:280 → 609
      UCH; Ubiquitin carboxyl-terminal hydrolase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      53308264..53336800
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008766138.4 → XP_008764360.1  ubiquitin carboxyl-terminal hydrolase 2 isoform X3

      Conserved Domains (2) summary
      cd02674
      Location:25 → 354
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:23 → 353
      UCH; Ubiquitin carboxyl-terminal hydrolase

    2. XM_039080702.2 → XP_038936630.1  ubiquitin carboxyl-terminal hydrolase 2 isoform X1

      UniProtKB/Swiss-Prot
      Q5U349, Q9QXL3, Q9QXL4, Q9R083, Q9R084
      UniProtKB/TrEMBL
      A0A8L2Q4I7
      Conserved Domains (1) summary
      pfam00443
      Location:280 → 609
      UCH; Ubiquitin carboxyl-terminal hydrolase

    3. XM_039080703.2 → XP_038936631.1  ubiquitin carboxyl-terminal hydrolase 2 isoform X1

      UniProtKB/Swiss-Prot
      Q5U349, Q9QXL3, Q9QXL4, Q9R083, Q9R084
      UniProtKB/TrEMBL
      A0A8L2Q4I7
      Conserved Domains (1) summary
      pfam00443
      Location:280 → 609
      UCH; Ubiquitin carboxyl-terminal hydrolase

    4. XM_039080704.2 → XP_038936632.1  ubiquitin carboxyl-terminal hydrolase 2 isoform X1

      UniProtKB/Swiss-Prot
      Q5U349, Q9QXL3, Q9QXL4, Q9R083, Q9R084
      UniProtKB/TrEMBL
      A0A8L2Q4I7
      Conserved Domains (1) summary
      pfam00443
      Location:280 → 609
      UCH; Ubiquitin carboxyl-terminal hydrolase

    5. XM_006242863.5 → XP_006242925.1  ubiquitin carboxyl-terminal hydrolase 2 isoform X2

      See identical proteins and their annotated locations for XP_006242925.1

      UniProtKB/Swiss-Prot
      Q5U349
      Related
      ENSRNOP00000030257.4
      Conserved Domains (2) summary
      cd02674
      Location:59 → 388
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:57 → 387
      UCH; Ubiquitin carboxyl-terminal hydrolase

    6. XM_008766139.3 → XP_008764361.1  ubiquitin carboxyl-terminal hydrolase 2 isoform X4

      Conserved Domains (2) summary
      cd02674
      Location:17 → 346
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:15 → 345
      UCH; Ubiquitin carboxyl-terminal hydrolase

    7. XM_063264776.1 → XP_063120846.1  ubiquitin carboxyl-terminal hydrolase 2 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U349.1 GenPept UniProtKB/Swiss-Prot:Q5U349

    Gene LinkOut

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