GPBAR1 G protein-coupled bile acid receptor 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GPBAR1provided by HGNC
Official Full Name: G protein-coupled bile acid receptor 1provided by HGNC
Primary source: HGNC:HGNC:19680
See related: Ensembl:ENSG00000179921 MIM:610147; AllianceGenome:HGNC:19680
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BG37; TGR5; M-BAR; GPCR19; GPR131
Summary: This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Expression: Biased expression in gall bladder (RPKM 4.9), fat (RPKM 2.9) and 11 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2q35

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (218259496..218263861)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (218745197..218749562)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (219124219..219128584)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The function of the gut microbiota-bile acid-TGR5 axis in diarrhea-predominant irritable bowel syndrome.
Title: The function of the gut microbiota-bile acid-TGR5 axis in diarrhea-predominant irritable bowel syndrome.
Gut microbiota-mediated ursodeoxycholic acids regulate the inflammation of microglia through TGR5 signaling after MCAO.
Title: Gut microbiota-mediated ursodeoxycholic acids regulate the inflammation of microglia through TGR5 signaling after MCAO.
Activation of GPBAR1 attenuates vascular inflammation and atherosclerosis in a mouse model of NAFLD-related cardiovascular disease.
Title: Activation of GPBAR1 attenuates vascular inflammation and atherosclerosis in a mouse model of NAFLD-related cardiovascular disease.
GPBAR1 preserves neurite and synapse of dopaminergic neurons via RAD21-OPCML signaling: Role in preventing Parkinson's disease in mouse model and human patients.
Title: GPBAR1 preserves neurite and synapse of dopaminergic neurons via RAD21-OPCML signaling: Role in preventing Parkinson's disease in mouse model and human patients.
Lithocholic acid inhibits dendritic cell activation by reducing intracellular glutathione via TGR5 signaling.
Title: Lithocholic acid inhibits dendritic cell activation by reducing intracellular glutathione via TGR5 signaling.
Structural basis and molecular mechanism of biased GPBAR signaling in regulating NSCLC cell growth via YAP activity.
Title: Structural basis and molecular mechanism of biased GPBAR signaling in regulating NSCLC cell growth via YAP activity.
GPBAR1 promotes proliferation and is related to poor prognosis of high-grade glioma via inducing MAFB expression.
Title: GPBAR1 promotes proliferation and is related to poor prognosis of high-grade glioma via inducing MAFB expression.
GPCR19 Regulates P2X7R-Mediated NLRP3 Inflammasomal Activation of Microglia by Amyloid beta in a Mouse Model of Alzheimer's Disease.
Title: GPCR19 Regulates P2X7R-Mediated NLRP3 Inflammasomal Activation of Microglia by Amyloid β in a Mouse Model of Alzheimer's Disease.
GLP-1 Mediates Regulation of Colonic ACE2 Expression by the Bile Acid Receptor GPBAR1 in Inflammation.
Title: GLP-1 Mediates Regulation of Colonic ACE2 Expression by the Bile Acid Receptor GPBAR1 in Inflammation.
Faecal bile acids and colonic bile acid membrane receptor correlate with symptom severity of diarrhoea-predominant irritable bowel syndrome: A pilot study.
Title: Faecal bile acids and colonic bile acid membrane receptor correlate with symptom severity of diarrhoea-predominant irritable bowel syndrome: A pilot study.

Submit: New GeneRIF Correction See all GeneRIFs (87)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled bile acid receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled bile acid receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled bile acid receptor activity	NAS Non-traceable Author Statement more info	PubMed
enables bile acid receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface bile acid receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to bile acid	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cholangiocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of bicellular tight junction assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
part_of receptor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: G-protein coupled bile acid receptor 1

Names: G-protein coupled bile acid receptor BG37; G-protein coupled receptor GPCR19; membrane bile acid receptor; membrane-type receptor for bile acids

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077191.2 → NP_001070659.1 G-protein coupled bile acid receptor 1

See identical proteins and their annotated locations for NP_001070659.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.

Source sequence(s)

AC021016, AK122660, BC033625

Consensus CDS

CCDS46515.1

UniProtKB/Swiss-Prot

B3KV35, Q8TDU6

Related

ENSP00000430886.1, ENST00000522678.5

Conserved Domains (2) summary

cd14964
Location:49 → 75

7tm_GPCRs; TM helix 2 [structural motif]

cl28897
Location:28 → 284

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_001077194.2 → NP_001070662.1 G-protein coupled bile acid receptor 1

See identical proteins and their annotated locations for NP_001070662.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.

Source sequence(s)

AC021016, AK122660, BC033625, BI834364

Consensus CDS

CCDS46515.1

UniProtKB/Swiss-Prot

B3KV35, Q8TDU6

Related

ENSP00000428824.1, ENST00000521462.1

Conserved Domains (2) summary

cd14964
Location:49 → 75

7tm_GPCRs; TM helix 2 [structural motif]

cl28897
Location:28 → 284

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_001321950.2 → NP_001308879.1 G-protein coupled bile acid receptor 1

Status: REVIEWED

Source sequence(s)

AC021016, AK122658, BC033625

Consensus CDS

CCDS46515.1

UniProtKB/Swiss-Prot

B3KV35, Q8TDU6

Related

ENSP00000430698.1, ENST00000479077.5

Conserved Domains (2) summary

cd14964
Location:49 → 75

7tm_GPCRs; TM helix 2 [structural motif]

cl28897
Location:28 → 284

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_170699.3 → NP_733800.1 G-protein coupled bile acid receptor 1

See identical proteins and their annotated locations for NP_733800.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.

Source sequence(s)

AC021016, AK122660, BC033625

Consensus CDS

CCDS46515.1

UniProtKB/Swiss-Prot

B3KV35, Q8TDU6

Related

ENSP00000430202.1, ENST00000519574.2

Conserved Domains (2) summary

cd14964
Location:49 → 75

7tm_GPCRs; TM helix 2 [structural motif]

cl28897
Location:28 → 284

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

218259496..218263861

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011510743.1 → XP_011509045.1 G-protein coupled bile acid receptor 1 isoform X1

See identical proteins and their annotated locations for XP_011509045.1

UniProtKB/Swiss-Prot

B3KV35, Q8TDU6

Conserved Domains (2) summary

cd14964
Location:49 → 75

7tm_GPCRs; TM helix 2 [structural motif]

cl28897
Location:28 → 284

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily