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    Cdh22 cadherin 22 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29182, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Cdh22provided by RGD
    Official Full Name
    cadherin 22provided by RGD
    Primary source
    RGD:2321
    See related
    Ensembl:ENSRNOG00000018557 AllianceGenome:RGD:2321
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cadherin binding activity and calcium ion binding activity. Involved in brain development and calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules. Predicted to be integral component of membrane. Predicted to be part of catenin complex. Predicted to be active in adherens junction. Orthologous to human CDH22 (cadherin 22). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 50.4), Heart (RPKM 10.2) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    3q42
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (174264869..174389940, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (153845563..153970630, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (161574993..161971102, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene nuclear receptor coactivator 5 Neighboring gene uncharacterized LOC120101785 Neighboring gene CD40 molecule Neighboring gene uncharacterized LOC134486205 Neighboring gene uncharacterized LOC134486204

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Short-type PB-cadherin promotes survival of gonocytes and activates JAK-STAT signalling. Wu J, et al. Dev Biol, 2005 Aug 15. PMID 16038895
    2. Molecular cloning and characterization of a newly identified member of the cadherin family, PB-cadherin. Sugimoto K, et al. J Biol Chem, 1996 May 10. PMID 8626716
    3. Novel hepatic progenitor cell surface markers in the adult rat liver. Yovchev MI, et al. Hepatology, 2007 Jan. PMID 17187413
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cadherin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in adherens junction organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion mediated by cadherin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catenin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cadherin-22
    Names
    PB-cadherin
    pituitary and brain cadherin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019161.3 → NP_062034.2  cadherin-22 precursor

      See identical proteins and their annotated locations for NP_062034.2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q63315, Q63561
      UniProtKB/TrEMBL
      A6JXE3
      Related
      ENSRNOP00000025150.5, ENSRNOT00000025150.7
      Conserved Domains (2) summary
      cd11304
      Location:398 → 492
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam01049
      Location:645 → 804
      Cadherin_C; Cadherin cytoplasmic region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      174264869..174389940 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104424.2 → XP_038960352.1  cadherin-22 isoform X1

      UniProtKB/Swiss-Prot
      Q63315, Q63561
      UniProtKB/TrEMBL
      A6JXE3
      Conserved Domains (2) summary
      cd11304
      Location:398 → 492
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam01049
      Location:645 → 804
      Cadherin_C; Cadherin cytoplasmic region

    2. XM_039104425.2 → XP_038960353.1  cadherin-22 isoform X2

      UniProtKB/TrEMBL
      A6JXE4
      Conserved Domains (2) summary
      cd11304
      Location:232 → 326
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam01049
      Location:479 → 638
      Cadherin_C; Cadherin cytoplasmic region

    3. XM_039104426.2 → XP_038960354.1  cadherin-22 isoform X3

      Conserved Domains (3) summary
      cd11304
      Location:95 → 193
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:22 → 90
      CA; Cadherin repeats
      pfam01049
      Location:241 → 400
      Cadherin_C; Cadherin cytoplasmic region

    RNA

    1. XR_005501800.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63315.1 GenPept UniProtKB/Swiss-Prot:Q63315

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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