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    Pcyt1b phosphate cytidylyltransferase 1B, choline [ Rattus norvegicus (Norway rat) ]

    Gene ID: 286936, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Pcyt1bprovided by RGD
    Official Full Name
    phosphate cytidylyltransferase 1B, cholineprovided by RGD
    Primary source
    RGD:708434
    See related
    Ensembl:ENSRNOG00000012358 AllianceGenome:RGD:708434
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CTB; Cctbeta; CCT-beta
    Summary
    Predicted to enable choline-phosphate cytidylyltransferase activity; identical protein binding activity; and phosphatidylcholine binding activity. Involved in response to vasopressin. Predicted to be located in endoplasmic reticulum. Orthologous to human PCYT1B (phosphate cytidylyltransferase 1B, choline). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 62.8), Lung (RPKM 8.5) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pcyt1b in Genome Data Viewer
    Location:
    Xq22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (62371934..62465460)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (58378090..58471623)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (62727691..62821199)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene DNA polymerase alpha 1, catalytic subunit Neighboring gene solute carrier family 30 member 9, pseudogene 1 Neighboring gene small Cajal body-specific RNA 24 Neighboring gene NSA2 ribosome biogenesis factor, pseudogene 4 Neighboring gene pyruvate dehydrogenase kinase 3 Neighboring gene uncharacterized LOC120099286

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phosphatidylcholine biosynthesis via CTP:phosphocholine cytidylyltransferase 2 facilitates neurite outgrowth and branching. Carter JM, et al. J Biol Chem, 2008 Jan 4. PMID 17981805
    2. Cloning of a Gene in Rat Brain Induced to Be Expressed Differently by AVP(4-8) with Differential Display PCR. Xiong Y, et al. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai), 1999. PMID 12114961
    3. Cloning of cytidine triphosphate: phosphocholine cytidylyltransferase mRNA upregulated by a neuropeptide arginine-vasopressin((4-8)) in rat hippocampus. Xiong Y, et al. Neurosci Lett, 2000 Apr 7. PMID 10739892
    4. Crystal structure of a mammalian CTP: phosphocholine cytidylyltransferase catalytic domain reveals novel active site residues within a highly conserved nucleotidyltransferase fold. Lee J, et al. J Biol Chem, 2009 Nov 27. PMID 19783652, Free PMC Article
    5. Disruption of CCTbeta2 expression leads to gonadal dysfunction. Jackowski S, et al. Mol Cell Biol, 2004 Jun. PMID 15143167, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The 2.2-A structure reveals a CCT236 homodimer in complex with the reaction product, CDP-choline.
      Title: Crystal structure of a mammalian CTP: phosphocholine cytidylyltransferase catalytic domain reveals novel active site residues within a highly conserved nucleotidyltransferase fold.
    2. Results highlight the importance of CTbeta2 in neurons for promoting neurite outgrowth and branching and represent the first identification of a lipid biosynthetic enzyme that facilitates these functions.
      Title: Phosphatidylcholine biosynthesis via CTP:phosphocholine cytidylyltransferase 2 facilitates neurite outgrowth and branching.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables choline-phosphate cytidylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables choline-phosphate cytidylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables choline-phosphate cytidylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables choline-phosphate cytidylyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylcholine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in CDP-choline pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in CDP-choline pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in CDP-choline pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ovarian follicle development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ovarian follicle development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylcholine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylcholine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to vasopressin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    choline-phosphate cytidylyltransferase B
    Names
    CCT B
    CT B
    CTP:phosphocholine cytidylyltransferase B
    choline phosphate cytidylyltransferase 1 beta
    phosphate cytidylyltransferase 1, choline, beta
    phosphorylcholine transferase B
    NP_775174.2
    XP_006257078.1
    XP_006257079.1
    XP_038955447.1
    XP_038955448.1
    XP_038955449.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173151.2 → NP_775174.2  choline-phosphate cytidylyltransferase B

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      Q9QZC4
      UniProtKB/TrEMBL
      A6IPZ8, G3V7M5
      Related
      ENSRNOP00000016669.4, ENSRNOT00000016669.7
      Conserved Domains (1) summary
      PLN02413
      Location:72 → 314
      PLN02413; choline-phosphate cytidylyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      62371934..62465460
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006257017.5 → XP_006257079.1  choline-phosphate cytidylyltransferase B isoform X2

      UniProtKB/Swiss-Prot
      Q9QZC4
      UniProtKB/TrEMBL
      A0A096MK76
      Related
      ENSRNOP00000068408.1
      Conserved Domains (1) summary
      cd02174
      Location:55 → 204
      CCT; CTP:phosphocholine cytidylyltransferase

    2. XM_039099521.2 → XP_038955449.1  choline-phosphate cytidylyltransferase B isoform X3

      Conserved Domains (1) summary
      PLN02413
      Location:2 → 197
      PLN02413; choline-phosphate cytidylyltransferase

    3. XM_006257016.5 → XP_006257078.1  choline-phosphate cytidylyltransferase B isoform X1

      UniProtKB/Swiss-Prot
      Q9QZC4
      UniProtKB/TrEMBL
      A0A8I5ZK90
      Related
      ENSRNOP00000077206.1
      Conserved Domains (1) summary
      PLN02413
      Location:52 → 294
      PLN02413; choline-phosphate cytidylyltransferase

    4. XM_039099520.2 → XP_038955448.1  choline-phosphate cytidylyltransferase B isoform X3

      Conserved Domains (1) summary
      PLN02413
      Location:2 → 197
      PLN02413; choline-phosphate cytidylyltransferase

    5. XM_039099519.2 → XP_038955447.1  choline-phosphate cytidylyltransferase B isoform X3

      Conserved Domains (1) summary
      PLN02413
      Location:2 → 197
      PLN02413; choline-phosphate cytidylyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZC4.1 GenPept UniProtKB/Swiss-Prot:Q9QZC4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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