Hsd17b8 hydroxysteroid (17-beta) dehydrogenase 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hsd17b8provided by RGD
Official Full Name: hydroxysteroid (17-beta) dehydrogenase 8provided by RGD
Primary source: RGD:1303158
See related: Ensembl:ENSRNOG00000000466 AllianceGenome:RGD:1303158
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ke6; Fabgl; RING2
Summary: Predicted to enable NADH binding activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; and quinone binding activity. Predicted to be involved in estrogen biosynthetic process; fatty acid biosynthetic process; and protein heterotetramerization. Predicted to act upstream of or within androgen metabolic process and estrogen metabolic process. Predicted to be located in mitochondrial envelope; mitochondrial matrix; and plasma membrane. Predicted to be part of oxidoreductase complex. Orthologous to human HSD17B8 (hydroxysteroid 17-beta dehydrogenase 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 229.9), Kidney (RPKM 172.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (4828571..4830635)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (4826725..4828742)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (3817212..3819316, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH133333 (e-PCR)
- UniSTS:216616

H2-Ke6 (e-PCR), detects polymorphism
- UniSTS:463413

Slc39a7 (e-PCR), detects polymorphism
- UniSTS:463430

RH129332 (e-PCR)
- UniSTS:212639

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables (3R)-hydroxyacyl-CoA dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables (3R)-hydroxyacyl-CoA dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables (3R)-hydroxyacyl-CoA dehydrogenase (NAD+) activity	ISS Inferred from Sequence or Structural Similarity more info
enables NADH binding	IEA Inferred from Electronic Annotation more info
enables NADH binding	ISO Inferred from Sequence Orthology more info
enables NADH binding	ISS Inferred from Sequence or Structural Similarity more info
enables estradiol 17-beta-dehydrogenase [NAD(P)] activity	IBA Inferred from Biological aspect of Ancestor more info
enables estradiol 17-beta-dehydrogenase [NAD(P)] activity	IEA Inferred from Electronic Annotation more info
enables estradiol 17-beta-dehydrogenase [NAD(P)] activity	ISO Inferred from Sequence Orthology more info
enables estradiol 17-beta-dehydrogenase [NAD(P)] activity	ISS Inferred from Sequence or Structural Similarity more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables testosterone dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables testosterone dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in androgen metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within androgen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in estrogen biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in estrogen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in estrogen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in estrogen biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within estrogen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein heterotetramerization	IEA Inferred from Electronic Annotation more info
involved_in protein heterotetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein heterotetramerization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial envelope	IEA Inferred from Electronic Annotation more info
located_in mitochondrial envelope	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
part_of oxidoreductase complex	IEA Inferred from Electronic Annotation more info
part_of oxidoreductase complex	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: (3R)-3-hydroxyacyl-CoA dehydrogenase

Names: 17-beta-HSD 8; 17-beta-hydroxysteroid dehydrogenase 8; 3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit; 3-oxoacyl-[acyl-carrier-protein] reductase; KAR alpha subunit; estradiol 17-beta-dehydrogenase 8; testosterone 17-beta-dehydrogenase 8

NP_997694.1

EC 1.1.1.239

EC 1.1.1.62

EC 1.1.1.n12

XP_006256026.1

EC 1.1.1.239

EC 1.1.1.62

EC 1.1.1.n12

XP_006256027.1

EC 1.1.1.239

EC 1.1.1.62

EC 1.1.1.n12

XP_006256028.1

EC 1.1.1.239

EC 1.1.1.62

EC 1.1.1.n12

XP_038954738.1

EC 1.1.1.239

EC 1.1.1.62

EC 1.1.1.n12

XP_063135282.1

EC 1.1.1.239

EC 1.1.1.62

EC 1.1.1.n12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212529.1 → NP_997694.1 (3R)-3-hydroxyacyl-CoA dehydrogenase

See identical proteins and their annotated locations for NP_997694.1

Status: VALIDATED

Source sequence(s)

BX883042

UniProtKB/Swiss-Prot

Q6MGB5

UniProtKB/TrEMBL

A6JJG1

Conserved Domains (1) summary

cd05333
Location:11 → 258

BKR_SDR_c; beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

4828571..4830635

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039098810.2 → XP_038954738.1 (3R)-3-hydroxyacyl-CoA dehydrogenase isoform X4

Conserved Domains (1) summary

cl21454
Location:16 → 218

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_006255964.5 → XP_006256026.1 (3R)-3-hydroxyacyl-CoA dehydrogenase isoform X1

UniProtKB/TrEMBL

A0A0G2K6P1

Related

ENSRNOP00000073887.2

Conserved Domains (1) summary

cd05333
Location:16 → 257

BKR_SDR_c; beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs
XM_006255966.5 → XP_006256028.1 (3R)-3-hydroxyacyl-CoA dehydrogenase isoform X3

UniProtKB/TrEMBL

A0A0G2K156

Related

ENSRNOP00000071707.2

Conserved Domains (1) summary

cd05333
Location:16 → 260

BKR_SDR_c; beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs
XM_006255965.5 → XP_006256027.1 (3R)-3-hydroxyacyl-CoA dehydrogenase isoform X2

See identical proteins and their annotated locations for XP_006256027.1

UniProtKB/TrEMBL

A6JJG3

Conserved Domains (1) summary

cd05333
Location:11 → 255

BKR_SDR_c; beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs
XM_063279212.1 → XP_063135282.1 (3R)-3-hydroxyacyl-CoA dehydrogenase isoform X5