Vav2 vav guanine nucleotide exchange factor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Vav2provided by RGD
Full Name: vav guanine nucleotide exchange factor 2provided by RGD
Primary source: RGD:1306285
See related: Ensembl:ENSRNOG00000007422 AllianceGenome:RGD:1306285
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable epidermal growth factor receptor binding activity; guanyl-nucleotide exchange factor activity; and phosphotyrosine residue binding activity. Predicted to be involved in regulation of GTPase activity and regulation of cell size. Predicted to act upstream of or within several processes, including lamellipodium assembly; positive regulation of phosphatidylinositol 3-kinase activity; and small GTPase mediated signal transduction. Predicted to be located in cytoplasm and plasma membrane. Orthologous to human VAV2 (vav guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 201.8), Kidney (RPKM 114.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p12

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (30982754..31152116, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (10584688..10754128, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (5811504..5976311, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our data provide the first evidence to implicate VAV2 in glucose-induced Rac1 activation, actin remodelling and glucose-stimulated insulin secretion in pancreatic beta cells.
Title: VAV2, a guanine nucleotide exchange factor for Rac1, regulates glucose-stimulated insulin secretion in pancreatic beta cells.
This study suggested that ephrinAs produced by astrocytes are involved in inhibition of Schwann cell migration and that this effect is mediated through EphA receptors on Schwann cells, leading to VAV2 signaling and interception of integrin function.
Title: Astrocyte-produced ephrins inhibit schwann cell migration via VAV2 signaling.
stretch-induced RhoA activation is dependent on transactivation of the EGFR and activation of the RhoGEF Vav2.
Title: Mechanical stretch-induced RhoA activation is mediated by the RhoGEF Vav2 in mesangial cells.
Vav2-mediated activation of NADPH oxidase is an important initiating mechanism resulting in hyperhomocysteinemic glomerular injury through enhanced local oxidative stress.
Title: Contribution of guanine nucleotide exchange factor Vav2 to hyperhomocysteinemic glomerulosclerosis in rats.

Submit: New GeneRIF Correction

General gene information

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Markers

BF387160 (e-PCR)
- UniSTS:244225

U37017 (e-PCR)
- UniSTS:125737

AI847175 (e-PCR)
- UniSTS:164150

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables epidermal growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphotyrosine residue binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell projection assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lamellipodium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in regulation of cell size	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell size	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within small GTPase-mediated signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: guanine nucleotide exchange factor VAV2

Names: Vav2 oncogene; vav 2 guanine nucleotide exchange factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106563.2 → NP_001100033.2 guanine nucleotide exchange factor VAV2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I6APU5, D3ZYG0

Related

ENSRNOP00000009893.5, ENSRNOT00000009893.7

Conserved Domains (8) summary

cd10406
Location:657 → 759

SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins

cd11977
Location:809 → 866

SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein

cd11980
Location:580 → 639

SH3_VAV2_1; First Src homology 3 domain of VAV2 protein

cd00029
Location:514 → 561

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd01223
Location:384 → 506

PH_Vav; Vav pleckstrin homology (PH) domain

pfam00169
Location:401 → 502

PH; PH domain

pfam00621
Location:197 → 370

RhoGEF; RhoGEF domain

pfam11971
Location:18 → 103

CAMSAP_CH; CAMSAP CH domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

30982754..31152116 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006233761.3 → XP_006233823.1 guanine nucleotide exchange factor VAV2 isoform X3

UniProtKB/TrEMBL

A0A8I6APU5

Conserved Domains (8) summary

cd10406
Location:657 → 759

SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins

cd11977
Location:780 → 837

SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein

cd11980
Location:580 → 639

SH3_VAV2_1; First Src homology 3 domain of VAV2 protein

cd00029
Location:514 → 561

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd01223
Location:384 → 506

PH_Vav; Vav pleckstrin homology (PH) domain

pfam00169
Location:401 → 502

PH; PH domain

pfam00621
Location:197 → 370

RhoGEF; RhoGEF domain

pfam11971
Location:18 → 103

CAMSAP_CH; CAMSAP CH domain
XM_063283478.1 → XP_063139548.1 guanine nucleotide exchange factor VAV2 isoform X2
XM_039104731.2 → XP_038960659.1 guanine nucleotide exchange factor VAV2 isoform X1

UniProtKB/TrEMBL

A0A8I6APU5

Related

ENSRNOP00000089811.1

Conserved Domains (7) summary

cd10406
Location:662 → 764

SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins

cd11977
Location:814 → 871

SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein

cd11980
Location:585 → 644

SH3_VAV2_1; First Src homology 3 domain of VAV2 protein

cd00160
Location:194 → 369

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd01223
Location:384 → 511

PH_Vav; Vav pleckstrin homology (PH) domain

cd21263
Location:2 → 120

CH_VAV2; calponin homology (CH) domain found in VAV2 protein and similar proteins

cd20868
Location:514 → 571

C1_VAV2; protein kinase C conserved region 1 (C1 domain) found in VAV2 protein
XM_063283479.1 → XP_063139549.1 guanine nucleotide exchange factor VAV2 isoform X4