Htr1b 5-hydroxytryptamine receptor 1B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Htr1bprovided by RGD
Official Full Name: 5-hydroxytryptamine receptor 1Bprovided by RGD
Primary source: RGD:2846
See related: Ensembl:ENSRNOG00000013042 AllianceGenome:RGD:2846
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables G protein-coupled serotonin receptor activity; heterocyclic compound binding activity; and voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels. Involved in several processes, including modulation of chemical synaptic transmission; regulation of amine transport; and response to cocaine. Located in plasma membrane. Is active in calyx of Held. Used to study anxiety disorder. Biomarker of hypertension; ischemia; and obesity. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder and conduct disorder. Orthologous to human HTR1B (5-hydroxytryptamine receptor 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 23.4), Muscle (RPKM 6.9) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q31

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (91395405..91414815, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (82513572..82534670, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (89113984..89130830, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The protective effect of alpha7-nACh receptor and its interaction with 5-HT1B/1D receptors in acute intestinal ischemia-reperfusion injury in rats.
Title: The protective effect of α7-nACh receptor and its interaction with 5-HT1B/1D receptors in acute intestinal ischemia-reperfusion injury in rats.
Involvement of 5-HT1B/1D receptors in the inflammatory response and oxidative stress in intestinal ischemia/reperfusion in rats.
Title: Involvement of 5-HT1B/1D receptors in the inflammatory response and oxidative stress in intestinal ischemia/reperfusion in rats.
Selective Regulation of 5-HT1B Serotonin Receptor Expression in the Striatum by Dopamine Depletion and Repeated L-DOPA Treatment: Relationship to L-DOPA-Induced Dyskinesias.
Title: Selective Regulation of 5-HT1B Serotonin Receptor Expression in the Striatum by Dopamine Depletion and Repeated L-DOPA Treatment: Relationship to L-DOPA-Induced Dyskinesias.
findings indicate that stimulation of the 5-HT1B receptor can enhance methylphenidate-induced gene regulation.
Title: The 5-HT1B serotonin receptor regulates methylphenidate-induced gene expression in the striatum: Differential effects on immediate-early genes.
in rats immunized with M4R and M3R peptides the sensitivity of ACSS thyrocytes to TSH were decreased, whereas in rats iimunized with 5-HT1BR peptide the deficit of thyroid hormones was associated with decreased level of TSH
Title: [THE THYROID STATUS OF RATS IMMUNIZED WITH PEPTIDES DERIVED FROM THE EXTRACELLULAR REGIONS OF THE TYPES 3 AND 4 MELANOCORTIN RECEPTORS AND THE 1B-SUBTYPE 5-HYDROXYTRYPTAMINE RECEPTOR].
Results show that TRPM8 and the 5-HT1BR interact directly in a novel signalling complex that incorporates PLD1, which mediates the facilitatory influence by means of its product phosphatidic acid acting on PIP 5-kinase to increase production of PIP2
Title: The TRPM8 channel forms a complex with the 5-HT(1B) receptor and phospholipase D that amplifies its reversal of pain hypersensitivity.
Adaptive changes on 5-HT1B receptors induced by chronic venlafaxine administration exhibit regional brain differences, with the hypothalamus the site of drug action.
Title: Region-specific regulation of 5-HT1B receptors in the rat brain by chronic venlafaxine treatment.
Single artery occlusion without significant visible infarct resulted in locally increased ETB, angiotensin type 1 and 5-hydroxytryptamine 1B receptor-mediated contractile responses only in segments located downstream of the occlusion site.
Title: Permanent distal occlusion of middle cerebral artery in rat causes local increased ETB, 5-HT₁B and AT₁ receptor-mediated contractility downstream of occlusion.
5-HTB/D receptors have a role in the reduction of formalin-induced nociception and secondary allodynia/hyperalgesia. produced by antimigraine drugs in rats
Title: Role of 5-HT₁B/₁D receptors in the reduction of formalin-induced nociception and secondary allodynia/hyperalgesia produced by antimigraine drugs in rats.
Secondhand smoke exposure upregulates cerebrovascular 5-HT(1) (B) receptors in rats associated with Raf/ERK/MAPK activation.
Title: Secondhand cigarette smoke exposure causes upregulation of cerebrovascular 5-HT(1) (B) receptors via the Raf/ERK/MAPK pathway in rats.

Submit: New GeneRIF Correction See all GeneRIFs (43)

General gene information

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Markers

UniSTS:491331 (e-PCR)
- UniSTS:491331

GDB:580614 (e-PCR)
- UniSTS:157841

PMC166422P1 (e-PCR)
- UniSTS:271594

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled serotonin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled serotonin receptor activity	ISO Inferred from Sequence Orthology more info
enables heterocyclic compound binding	IDA Inferred from Direct Assay more info	PubMed
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serotonin binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	EXP Inferred from Experiment more info	PubMed
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within bone remodeling	ISO Inferred from Sequence Orthology more info
involved_in cellular response to alkaloid	ISO Inferred from Sequence Orthology more info
involved_in cellular response to alkaloid	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to temperature stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to xenobiotic stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in drinking behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gamma-aminobutyric acid secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of serotonin secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of serotonin secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of synaptic transmission, GABAergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in presynaptic modulation of chemical synaptic transmission	EXP Inferred from Experiment more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of behavior	IEA Inferred from Electronic Annotation more info
involved_in regulation of dopamine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of presynaptic cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic vesicle exocytosis	EXP Inferred from Experiment more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in response to cocaine	IDA Inferred from Direct Assay more info	PubMed
involved_in response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to mineralocorticoid	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to toxic substance	ISO Inferred from Sequence Orthology more info
involved_in vasoconstriction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of G protein-coupled serotonin receptor complex	ISO Inferred from Sequence Orthology more info
is_active_in calyx of Held	EXP Inferred from Experiment more info	PubMed
is_active_in calyx of Held	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in serotonergic synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 5-hydroxytryptamine receptor 1B

Names: 5-HT-1B; 5-HT1B serotonin receptor; 5-hydroxytryptamine (serotonin ) receptor 1B; 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled; serotonin (5-hydroxytryptamine (5HT)) receptor type 1B; serotonin receptor 1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022225.3 → NP_071561.1 5-hydroxytryptamine receptor 1B

See identical proteins and their annotated locations for NP_071561.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

P28564

UniProtKB/TrEMBL

A6I1P1

Related

ENSRNOP00000017411.1, ENSRNOT00000017411.4

Conserved Domains (1) summary

cd15333
Location:42 → 376

7tmA_5-HT1B_1D; serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors