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    TRMT61A tRNA methyltransferase 61A [ Homo sapiens (human) ]

    Gene ID: 115708, updated on 5-May-2024

    Summary

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    Official Symbol
    TRMT61Aprovided by HGNC
    Official Full Name
    tRNA methyltransferase 61Aprovided by HGNC
    Primary source
    HGNC:HGNC:23790
    See related
    Ensembl:ENSG00000166166 AllianceGenome:HGNC:23790
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GCD14; TRM61; Gcd14p; hTRM61; C14orf172
    Summary
    Enables mRNA (adenine-N1-)-methyltransferase activity. Involved in mRNA methylation. Predicted to be located in nucleoplasm. Predicted to be part of tRNA (m1A) methyltransferase complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in endometrium (RPKM 4.4), prostate (RPKM 4.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    14q32.33
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (103529196..103537073)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (97765240..97773117)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (103995533..104003410)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103984081-103984968 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103986745-103987632 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6155 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103989409-103990294 Neighboring gene creatine kinase B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6157 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103999205-103999704 Neighboring gene uncharacterized LOC124903392 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104008443-104009162 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104009885-104010606 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6159 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9105 Neighboring gene RNA, U7 small nuclear 160 pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104027599-104028112 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9106 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6160 Neighboring gene BAG cochaperone 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA(3)(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target. Finer-Moore J, et al. J Mol Biol, 2015 Dec 4. PMID 26470919, Free PMC Article
    2. TRM6/61 connects PKCα with translational control through tRNAi(Met) stabilization: impact on tumorigenesis. Macari F, et al. Oncogene, 2016 Apr 7. PMID 26234676
    3. N(1)-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism. Wang Y, et al. Nat Commun, 2021 Nov 2. PMID 34728628, Free PMC Article
    4. Base-Resolution Mapping Reveals Distinct m(1)A Methylome in Nuclear- and Mitochondrial-Encoded Transcripts. Li X, et al. Mol Cell, 2017 Dec 7. PMID 29107537, Free PMC Article
    5. The m1A landscape on cytosolic and mitochondrial mRNA at single-base resolution. Safra M, et al. Nature, 2017 Nov 9. PMID 29072297

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N(1)-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism.
      Title: N(1)-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism.
    2. we suggest that PKCA tightly controls TRM6/61 activity to prevent translation deregulation that would favor neoplastic development.
      Title: TRM6/61 connects PKCα with translational control through tRNAi(Met) stabilization: impact on tumorigenesis.
    3. The TRM61 heterotetramer is the only active species, both subunits are required for orientating tRNA for catalysis at Trm61.
      Title: Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA(3)(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ40452

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables mRNA (adenine-N1-)-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tRNA (adenine(58)-N1)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of tRNA (m1A) methyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of tRNA (m1A) methyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A
    Names
    mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A
    tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRM61
    tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRMT61A
    tRNA methyltransferase 61 homolog A
    tRNA(m1A58)-methyltransferase subunit TRM61
    tRNA(m1A58)-methyltransferase subunit TRMT61A
    tRNA(m1A58)MTase subunit TRM61
    tRNA(m1A58)MTase subunit TRMT61A
    NP_689520.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152307.3 → NP_689520.2  tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A

      See identical proteins and their annotated locations for NP_689520.2

      Status: VALIDATED

      Source sequence(s)
      AL133367, AL139300
      Consensus CDS
      CCDS41994.1
      UniProtKB/Swiss-Prot
      A6NN78, Q8N7Q9, Q96FX7
      Related
      ENSP00000374399.4, ENST00000389749.9
      Conserved Domains (2) summary
      pfam08704
      Location:64 → 286
      GCD14; tRNA methyltransferase complex GCD14 subunit
      pfam14801
      Location:23 → 58
      GCD14_N; tRNA methyltransferase complex GCD14 subunit N-term

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      103529196..103537073
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      97765240..97773117
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96FX7.1 GenPept UniProtKB/Swiss-Prot:Q96FX7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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