Washc4 WASH complex subunit 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Washc4provided by MGI
Official Full Name: WASH complex subunit 4provided by MGI
Primary source: MGI:MGI:2441787
See related: Ensembl:ENSMUSG00000034560 AllianceGenome:MGI:2441787
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Kiaa1033; mKIAA1033; A230046K03Rik
Summary: Involved in endosomal transport. Located in endosome. Part of WASH complex. Is expressed in early conceptus and oocyte. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human WASHC4 (WASH complex subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in placenta adult (RPKM 6.5), CNS E11.5 (RPKM 5.1) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 41.29 cM

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (83379073..83432350)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (83543620..83596473)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124990 (e-PCR)
- UniSTS:161812

D11Bhm20 (e-PCR), detects polymorphism
- UniSTS:141619

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cognition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endolysosomal toll-like receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosomal transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosomal transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endosomal transport	ISO Inferred from Sequence Orthology more info
involved_in endosomal transport	NAS Non-traceable Author Statement more info	PubMed
involved_in endosome organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosome organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of Arp2/3 complex-mediated actin nucleation	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of protein complex stability	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of BLOC-1 complex	ISO Inferred from Sequence Orthology more info
part_of WASH complex	IBA Inferred from Biological aspect of Ancestor more info
part_of WASH complex	IDA Inferred from Direct Assay more info	PubMed
part_of WASH complex	ISO Inferred from Sequence Orthology more info
part_of WASH complex	NAS Non-traceable Author Statement more info	PubMed
located_in early endosome membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: WASH complex subunit 4

Names: WASH complex subunit 7; WASH complex subunit SWIP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033375.2 → NP_001028547.2 WASH complex subunit 4

See identical proteins and their annotated locations for NP_001028547.2

Status: VALIDATED

Source sequence(s)

AI605037, AK038582, AK161247, BQ561687

Consensus CDS

CCDS36015.1

UniProtKB/Swiss-Prot

Q3TTQ9, Q3UMB9, Q6ZPZ7, Q8CAK8, Q8CGK0

Related

ENSMUSP00000039322.6, ENSMUST00000038388.7

Conserved Domains (3) summary

pfam14744
Location:612 → 945

WASH-7_mid; WASH complex subunit 7

pfam14745
Location:32 → 600

WASH-7_N; WASH complex subunit 7, N-terminal

pfam14746
Location:966 → 1135

WASH-7_C; WASH complex subunit 7, C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

83379073..83432350

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155807.1 → XP_036011700.1 WASH complex subunit 4 isoform X1

Conserved Domains (3) summary

pfam14744
Location:695 → 994

WASH-7_mid; WASH complex subunit 7

pfam14745
Location:122 → 690

WASH-7_N; WASH complex subunit 7, N-terminal

pfam14746
Location:1011 → 1180

WASH-7_C; WASH complex subunit 7, C-terminal
XM_017313963.3 → XP_017169452.1 WASH complex subunit 4 isoform X3

Conserved Domains (3) summary

pfam14744
Location:424 → 757

WASH-7_mid; WASH complex subunit 7

pfam14745
Location:1 → 412

WASH-7_N; WASH complex subunit 7, N-terminal

pfam14746
Location:779 → 947

WASH-7_C; WASH complex subunit 7, C-terminal
XM_030245113.2 → XP_030100973.1 WASH complex subunit 4 isoform X5

Conserved Domains (3) summary

pfam14744
Location:200 → 533

WASH-7_mid; WASH complex subunit 7

pfam14745
Location:1 → 188

WASH-7_N; WASH complex subunit 7, N-terminal

pfam14746
Location:555 → 723

WASH-7_C; WASH complex subunit 7, C-terminal
XM_006513737.4 → XP_006513800.2 WASH complex subunit 4 isoform X2

Conserved Domains (3) summary

pfam14744
Location:568 → 901

WASH-7_mid; WASH complex subunit 7

pfam14745
Location:8 → 556

WASH-7_N; WASH complex subunit 7, N-terminal

pfam14746
Location:923 → 1091

WASH-7_C; WASH complex subunit 7, C-terminal
XM_006513738.4 → XP_006513801.1 WASH complex subunit 4 isoform X4

Conserved Domains (3) summary

pfam14744
Location:485 → 818

WASH-7_mid; WASH complex subunit 7

pfam14745
Location:1 → 473

WASH-7_N; WASH complex subunit 7, N-terminal

pfam14746
Location:840 → 1008

WASH-7_C; WASH complex subunit 7, C-terminal
XM_006513739.4 → XP_006513802.1 WASH complex subunit 4 isoform X5

Conserved Domains (3) summary

pfam14744
Location:200 → 533

WASH-7_mid; WASH complex subunit 7

pfam14745
Location:1 → 188

WASH-7_N; WASH complex subunit 7, N-terminal

pfam14746
Location:555 → 723

WASH-7_C; WASH complex subunit 7, C-terminal