NAT10 N-acetyltransferase 10 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NAT10provided by HGNC
Official Full Name: N-acetyltransferase 10provided by HGNC
Primary source: HGNC:HGNC:29830
See related: Ensembl:ENSG00000135372 MIM:609221; AllianceGenome:HGNC:29830
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ALP; Kre33; NET43
Summary: The protein encoded by this gene is an RNA cytidine acetyltransferase involved in histone acetylation, tRNA acetylation, the biosynthesis of 18S rRNA, and the enhancement of nuclear architecture and chromatin organization. [provided by RefSeq, Oct 2016]
Expression: Ubiquitous expression in lymph node (RPKM 12.6), testis (RPKM 11.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11p13

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (34105629..34146908)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (34242631..34283911)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (34127176..34168455)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dissecting the oncogenic properties of essential RNA-modifying enzymes: a focus on NAT10.
Title: Dissecting the oncogenic properties of essential RNA-modifying enzymes: a focus on NAT10.
NAT10-mediated mRNA N4-acetylcytidine modification of MDR1 and BCRP promotes breast cancer progression.
Title: NAT10-mediated mRNA N4-acetylcytidine modification of MDR1 and BCRP promotes breast cancer progression.
N-Acetyltransferase 10 represses Uqcr11 and Uqcrb independently of ac4C modification to promote heart regeneration.
Title: N-Acetyltransferase 10 represses Uqcr11 and Uqcrb independently of ac4C modification to promote heart regeneration.
N-acetyltransferase 10 regulates alphavirus replication via N4-acetylcytidine (ac4C) modi fi cation of the lymphocyte antigen six family member E (LY6E) mRNA.
Title: N-acetyltransferase 10 regulates alphavirus replication via N4-acetylcytidine (ac4C) modiﬁcation of the lymphocyte antigen six family member E (LY6E) mRNA.
N-acetyltransferase NAT10 controls cell fates via connecting mRNA cytidine acetylation to chromatin signaling.
Title: N-acetyltransferase NAT10 controls cell fates via connecting mRNA cytidine acetylation to chromatin signaling.
RNPS1 stabilizes NAT10 protein to facilitate translation in cancer via tRNA ac[4]C modification.
Title: RNPS1 stabilizes NAT10 protein to facilitate translation in cancer via tRNA ac(4)C modification.
CLIC3 interacts with NAT10 to inhibit N4-acetylcytidine modification of p21 mRNA and promote bladder cancer progression.
Title: CLIC3 interacts with NAT10 to inhibit N4-acetylcytidine modification of p21 mRNA and promote bladder cancer progression.
Decreased expression of NAT10 in peripheral blood mononuclear cells from new-onset ankylosing spondylitis and its clinical significance.
Title: Decreased expression of NAT10 in peripheral blood mononuclear cells from new-onset ankylosing spondylitis and its clinical significance.
NAT10 Is Involved in Cardiac Remodeling Through ac4C-Mediated Transcriptomic Regulation.
Title: NAT10 Is Involved in Cardiac Remodeling Through ac4C-Mediated Transcriptomic Regulation.
NAT10 Promotes Malignant Progression of Lung Cancer via the NF-kappaB Signaling Pathway.
Title: NAT10 Promotes Malignant Progression of Lung Cancer via the NF-κB Signaling Pathway.

Submit: New GeneRIF Correction See all GeneRIFs (46)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	HIV-1 Gag interacts with NAT10 as demonstrated by proximity dependent biotinylation proteomics	PubMed
	gag	Interaction of HIV-1 Gag with N-acetyltransferase 10 (NAT10) is identified in a series of six affinity purification/mass spectrometry screens	PubMed
Rev	rev	HIV-1 Rev interacting protein, N-acetyltransferase-like protein (NAT10), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Clone Names

FLJ10774, FLJ12179, FLJ23850, KIAA1709, DKFZp434C116

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA polymerase binding	IPI Inferred from Physical Interaction more info	PubMed
enables N-acetyltransferase activity	EXP Inferred from Experiment more info	PubMed
enables RNA binding	HDA more info	PubMed
enables mRNA N-acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables rRNA cytidine N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA N-acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of telomere maintenance via telomerase	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein acetylation	IDA Inferred from Direct Assay more info	PubMed
involved_in rRNA acetylation involved in maturation of SSU-rRNA	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA modification	TAS Traceable Author Statement more info
involved_in regulation of centrosome duplication	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in ribosomal small subunit biogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in tRNA acetylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromosome, telomeric region	HDA more info	PubMed
located_in membrane	HDA more info	PubMed
located_in midbody	IDA Inferred from Direct Assay more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
part_of small-subunit processome	IDA Inferred from Direct Assay more info	PubMed
part_of telomerase holoenzyme complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: RNA cytidine acetyltransferase

Names: 18S rRNA cytosine acetyltransferase; N-acetyltransferase 10 (GCN5-related); N-acetyltransferase-like protein

NP_001137502.2

EC 2.3.1.-

NP_078938.3

EC 2.3.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_051821.2 RefSeqGene

Range

5002..46281

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001144030.2 → NP_001137502.2 RNA cytidine acetyltransferase isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks two exons in the 5' coding region and uses a downstream start codon, compared to variant 1. Isoform b has a shorter N-terminus, compared to isoform a.

Source sequence(s)

AC090469

Consensus CDS

CCDS44568.1

Related

ENSP00000433011.2, ENST00000531159.6

Conserved Domains (2) summary

PLN03229
Location:828 → 925

PLN03229; acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional

COG1444
Location:19 → 829

TmcA; tRNA(Met) C34 N-acetyltransferase TmcA [Translation, ribosomal structure and biogenesis]
NM_024662.3 → NP_078938.3 RNA cytidine acetyltransferase isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AC090469

Consensus CDS

CCDS7889.1

UniProtKB/Swiss-Prot

B4DFD5, E7ESU4, E9PMN9, Q86WK5, Q9C0F4, Q9H0A0, Q9HA61, Q9NVF2

Related

ENSP00000257829.3, ENST00000257829.8

Conserved Domains (2) summary

PLN03229
Location:900 → 997

PLN03229; acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional

COG1444
Location:20 → 901

TmcA; tRNA(Met) C34 N-acetyltransferase TmcA [Translation, ribosomal structure and biogenesis]