Plat plasminogen activator, tissue type [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Platprovided by RGD
Full Name: plasminogen activator, tissue typeprovided by RGD
Primary source: RGD:3342
See related: Ensembl:ENSRNOG00000019018 AllianceGenome:RGD:3342
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: tPA; PATISS
Summary: Predicted to enable phosphoprotein binding activity; serine-type endopeptidase activity; and signaling receptor binding activity. Involved in several processes, including cellular response to hormone stimulus; positive regulation of ovulation; and prevention of polyspermy. Located in cytoplasm; extracellular space; and synapse. Is active in several cellular components, including glutamatergic synapse; neuronal dense core vesicle; and perisynaptic space. Used to study disseminated intravascular coagulation and status epilepticus. Biomarker of brain edema; middle cerebral artery infarction; sciatic neuropathy; transient cerebral ischemia; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including antiphospholipid syndrome; diabetic angiopathy; factor VIII deficiency; osteonecrosis; and thrombophilia due to decreased release of PLAT. Orthologous to human PLAT (plasminogen activator, tissue type). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 333.5), Lung (RPKM 332.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.5

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (75943061..76022037, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (69240582..69265177, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (74098263..74122897, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The paradox of tPA in ischemic stroke: tPA knockdown following recanalization improves functional and histological outcomes.
Title: The paradox of tPA in ischemic stroke: tPA knockdown following recanalization improves functional and histological outcomes.
The interplay between MMP-12 and t-PA in the brain after ischemic stroke.
Title: The interplay between MMP-12 and t-PA in the brain after ischemic stroke.
Astrocyte tissue plasminogen activator expression during brain development and its role in pyramidal neuron neurite outgrowth.
Title: Astrocyte tissue plasminogen activator expression during brain development and its role in pyramidal neuron neurite outgrowth.
Tissue-type plasminogen activator-primed human iPSC-derived neural progenitor cells promote motor recovery after severe spinal cord injury.
Title: Tissue-type plasminogen activator-primed human iPSC-derived neural progenitor cells promote motor recovery after severe spinal cord injury.
t-PA expressed in ECs may help to form IT of the DA via activation of MMP-2 and disruption of IEL
Title: Tissue-type plasminogen activator contributes to remodeling of the rat ductus arteriosus.
The use of G-CSF to protect the vasculature may improve the clinical outcome of tPA even outside the currently indicated therapeutic window for ischemic stroke.
Title: Granulocyte colony-stimulating factor attenuates delayed tPA-induced hemorrhagic transformation in ischemic stroke rats by enhancing angiogenesis and vasculogenesis.
LRP1 assembles unique co-receptor systems to initiate cell signaling in response to tissue-type plasminogen activator and myelin-associated glycoprotein.
Title: LRP1 assembles unique co-receptor systems to initiate cell signaling in response to tissue-type plasminogen activator and myelin-associated glycoprotein.
Regulation of PAI-1 activity in astrocytes by valproic acid may affect both physiological and pathological processes in the brain by upregulating tPA activity.
Title: Valproic acid induces astrocyte-dependent neurite outgrowth from cultured rat primary cortical neuron via modulation of tPA/PAI-1 activity.
Together, because CPAI blocks both proteolytic and nonproteolytic tPA neurotoxicity, it is a promising therapeutics of neonatal HI injury either with or without infection.
Title: Plasminogen activator inhibitor-1 mitigates brain injury in a rat model of infection-sensitized neonatal hypoxia-ischemia.
Designed t-PA mutants with molecular properties that, in contrast to t-PA, do not induce neurotoxicity.
Title: Molecular requirements for safer generation of thrombolytics by bioengineering the tissue-type plasminogen activator A chain.

Submit: New GeneRIF Correction See all GeneRIFs (51)

General gene information

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Markers

RH128197 (e-PCR)
- UniSTS:211505

RH137954 (e-PCR)
- UniSTS:220041

RH94475 (e-PCR)
- UniSTS:119723

BE120928 (e-PCR)
- UniSTS:247476

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphoprotein binding	IEA Inferred from Electronic Annotation more info
enables phosphoprotein binding	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to dexamethasone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to follicle-stimulating hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to luteinizing hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of proteolysis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of proteolysis	ISO Inferred from Sequence Orthology more info
involved_in plasminogen activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in plasminogen activation	IDA Inferred from Direct Assay more info	PubMed
involved_in plasminogen activation	IEA Inferred from Electronic Annotation more info
involved_in plasminogen activation	ISO Inferred from Sequence Orthology more info
involved_in platelet-derived growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in platelet-derived growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in prevention of polyspermy	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within proteolysis	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic plasticity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fatty acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in smooth muscle cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in smooth muscle cell migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trans-synaptic signaling by BDNF, modulating synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in trans-synaptic signaling by BDNF, modulating synaptic transmission	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in apical part of cell	IEA Inferred from Electronic Annotation more info
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
NOT located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in neuronal dense core vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuronal dense core vesicle	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in perisynaptic space	IDA Inferred from Direct Assay more info	PubMed
is_active_in perisynaptic space	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in secretory granule	IEA Inferred from Electronic Annotation more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info
part_of serine protease inhibitor complex	IEA Inferred from Electronic Annotation more info
part_of serine protease inhibitor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tissue-type plasminogen activator

Names: t-PA; t-plasminogen activator; tissue plasminogen activator; tissue-type plasminogen activator-like

NP_037283.2

EC 3.4.21.68

XP_006253409.3

EC 3.4.21.68

XP_063131168.1

EC 3.4.21.68

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013151.3 → NP_037283.2 tissue-type plasminogen activator precursor

See identical proteins and their annotated locations for NP_037283.2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000016

UniProtKB/Swiss-Prot

P19637

UniProtKB/TrEMBL

A0A0G2K1V0, A6IW59

Conserved Domains (3) summary

cd00108
Location:210 → 295

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

cd00190
Location:311 → 556

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam00051
Location:124 → 205

Kringle; Kringle domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

75943061..76022037 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063275098.1 → XP_063131168.1 tissue-type plasminogen activator isoform X2

UniProtKB/Swiss-Prot

P19637

UniProtKB/TrEMBL

A0A0G2K1V0, A6IW59
XM_006253347.5 → XP_006253409.3 tissue-type plasminogen activator isoform X1

UniProtKB/TrEMBL

A0A0G2K1V0, A0A8L2QF83