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    Irak1bp1 interleukin-1 receptor-associated kinase 1 binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300862, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Irak1bp1provided by RGD
    Official Full Name
    interleukin-1 receptor-associated kinase 1 binding protein 1provided by RGD
    Primary source
    RGD:1305012
    See related
    Ensembl:ENSRNOG00000008984 AllianceGenome:RGD:1305012
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in I-kappaB kinase/NF-kappaB signaling. Predicted to be located in cytoplasm and nucleus. Orthologous to human IRAK1BP1 (interleukin 1 receptor associated kinase 1 binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 97.0), Testes (RPKM 82.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Irak1bp1 in Genome Data Viewer
    Location:
    8q31
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (92608468..92628377)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (83731512..83748289)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (90343307..90360085)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene tumor protein, translationally-controlled 1 pseudogene 4 Neighboring gene pleckstrin homology domain interacting protein Neighboring gene uncharacterized LOC108351752

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. SIMPL is a tumor necrosis factor-specific regulator of nuclear factor-kappaB activity. Vig E, et al. J Biol Chem, 2001 Mar 16. PMID 11096118
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables signaling adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-1 receptor-associated kinase 1-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277283.1 → NP_001264212.1  interleukin-1 receptor-associated kinase 1-binding protein 1

      See identical proteins and their annotated locations for NP_001264212.1

      Status: VALIDATED

      Source sequence(s)
      BC159433, JAXUCZ010000008
      UniProtKB/TrEMBL
      A6I1P8, B0K033, D3ZBV8
      Related
      ENSRNOP00000062372.2, ENSRNOT00000068482.4
      Conserved Domains (1) summary
      pfam04402
      Location:55 → 196
      SIMPL; Protein of unknown function (DUF541)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      92608468..92628377
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265187.1 → XP_063121257.1  interleukin-1 receptor-associated kinase 1-binding protein 1 isoform X1

    RNA

    1. XR_010053950.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106843.1: Suppressed sequence

      Description
      NM_001106843.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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