Spata13 spermatogenesis associated 13 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Spata13provided by RGD
Official Full Name: spermatogenesis associated 13provided by RGD
Primary source: RGD:1307364
See related: Ensembl:ENSRNOG00000013707 AllianceGenome:RGD:1307364
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable guanyl-nucleotide exchange factor activity and identical protein binding activity. Predicted to be involved in cell migration; plasma membrane bounded cell projection assembly; and regulation of cell migration. Predicted to be located in several cellular components, including filopodium; lamellipodium; and ruffle membrane. Orthologous to human SPATA13 (spermatogenesis associated 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 175.4), Lung (RPKM 94.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p12

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (38954585..39083752)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (34778479..34907645)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (40937652..41066645)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The guanine nucleotide exchange factor (GEF) Asef2 (Spata13) promotes dendritic spine formation via Rac activation and spinophilin-dependent targeting.
Title: The guanine nucleotide exchange factor (GEF) Asef2 promotes dendritic spine formation via Rac activation and spinophilin-dependent targeting.

Submit: New GeneRIF Correction

General gene information

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Markers

D15Got33 (e-PCR)
- UniSTS:113707

BE119336 (e-PCR)
- UniSTS:249164

D15Mco14 (e-PCR)
- UniSTS:239502

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in filopodium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in lamellipodium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in filopodium	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: spermatogenesis-associated protein 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191686.1 → NP_001178615.1 spermatogenesis-associated protein 13

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000015

UniProtKB/TrEMBL

A0A8I6ACW7

Conserved Domains (4) summary

cd11973
Location:729 → 800

SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor

cd01224
Location:1023 → 1161

PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain

pfam00169
Location:1051 → 1150

PH; PH domain

pfam00621
Location:839 → 1018

RhoGEF; RhoGEF domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

38954585..39083752

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006252113.5 → XP_006252175.1 spermatogenesis-associated protein 13 isoform X1

UniProtKB/TrEMBL

A0A8I6ACW7, D3ZWB4

Related

ENSRNOP00000018406.7

Conserved Domains (4) summary

cd11973
Location:727 → 798

SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor

cd01224
Location:1021 → 1159

PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain

pfam00169
Location:1049 → 1148

PH; PH domain

pfam00621
Location:837 → 1016

RhoGEF; RhoGEF domain
XM_006252114.5 → XP_006252176.1 spermatogenesis-associated protein 13 isoform X2

Conserved Domains (4) summary

cd11973
Location:230 → 301

SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor

cd01224
Location:524 → 662

PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain

pfam00169
Location:552 → 651

PH; PH domain

pfam00621
Location:340 → 519

RhoGEF; RhoGEF domain
XM_039093323.2 → XP_038949251.1 spermatogenesis-associated protein 13 isoform X4

Conserved Domains (3) summary

smart00325
Location:84 → 263

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd01224
Location:268 → 406

PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain

cl17036
Location:1 → 43

SH3; Src Homology 3 domain superfamily
XM_006252115.5 → XP_006252177.1 spermatogenesis-associated protein 13 isoform X3

UniProtKB/TrEMBL

A0A8I6A3P0, A6K6A4

Related

ENSRNOP00000087721.1

Conserved Domains (4) summary

cd11973
Location:56 → 127

SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor

cd01224
Location:350 → 488

PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain

pfam00169
Location:378 → 477

PH; PH domain

pfam00621
Location:166 → 345

RhoGEF; RhoGEF domain