Rtn4rl2 reticulon 4 receptor-like 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rtn4rl2provided by RGD
Official Full Name: reticulon 4 receptor-like 2provided by RGD
Primary source: RGD:727797
See related: Ensembl:ENSRNOG00000021513 AllianceGenome:RGD:727797
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ngrh1
Summary: Enables signaling receptor activity. Involved in cell surface receptor signaling pathway and negative regulation of neuron projection development. Located in several cellular components, including external side of plasma membrane; membrane raft; and perikaryon. Orthologous to human RTN4RL2 (reticulon 4 receptor like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 10.2), Brain (RPKM 9.9) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q24

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (90361234..90377775, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (69954557..69971108, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (72272814..72289310, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NEP1-40-overexpressing Neural Stem Cells Enhance Axon Regeneration by Inhibiting Nogo-A/NgR1 Signaling Pathway.
Title: NEP1-40-overexpressing Neural Stem Cells Enhance Axon Regeneration by Inhibiting Nogo-A/NgR1 Signaling Pathway.
NEP140 promotes myelin regeneration via upregulation of GAP43 and MAP2 expression after focal cerebral ischemia in rats.
Title: NEP1‑40 promotes myelin regeneration via upregulation of GAP‑43 and MAP‑2 expression after focal cerebral ischemia in rats.
spatio-temporal expression pattern of NgR1, NgR2 & NgR3 mRNAs & corresponding proteins in developing olfactory system; data suggest, in non-pathological conditions, NgR1 & homologs may play a role in axon outgrowth in the olfactory system.
Title: Spatio-temporal expression pattern of receptors for myelin-associated inhibitors in the developing rat olfactory system.
crystal structure of the leucine-rich repeat region and part of the stalk regions of NgR2 and comparison to the previously reported NgR1 structure with respect to the distinct signaling properties of the two receptor isoforms
Title: Crystal structure of the Nogo-receptor-2.
The authors' results indicate that severed rubrospinal axons respond to NEP1-40 treatment but less robustly than corticospinal, raphe-spinal, or dorsal root axons.
Title: Nogo-66 receptor antagonist peptide (NEP1-40) administration promotes functional recovery and axonal growth after lateral funiculus injury in the adult rat.
Downregulation of Nogo receptor(NgR) after kainic acid or wheel-running in cortex and hippocampus suggests a role for NgR and Nogo-A in plasticity, learning and memory.
Title: Activity-induced and developmental downregulation of the Nogo receptor.

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General gene information

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Markers

AU048821 (e-PCR)
- UniSTS:145271

BE113531 (e-PCR)
- UniSTS:246695

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in corpus callosum development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: reticulon-4 receptor-like 2

Names: Nogo-66 receptor homolog 1; ngR2; nogo receptor-like 3; nogo-66 receptor-related protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181380.2 → NP_852045.1 reticulon-4 receptor-like 2 precursor

See identical proteins and their annotated locations for NP_852045.1

Status: PROVISIONAL

Source sequence(s)

AF532860

UniProtKB/Swiss-Prot

Q80WD1

UniProtKB/TrEMBL

A0A8I6AME5, A6HMS2

Related

ENSRNOP00000095119.1, ENSRNOT00000105407.1

Conserved Domains (4) summary

cd00116
Location:103 → 261

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:62 → 83

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:156 → 215

LRR_8; Leucine rich repeat

cl15307
Location:261 → 311

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

90361234..90377775 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006234465.5 → XP_006234527.1 reticulon-4 receptor-like 2 isoform X1

See identical proteins and their annotated locations for XP_006234527.1

UniProtKB/TrEMBL

A0A8L2QGV6, A6HMS3

Conserved Domains (4) summary

cd00116
Location:71 → 229

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:30 → 51

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:124 → 183

LRR_8; Leucine rich repeat

cl15307
Location:229 → 279

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
XM_006234466.4 → XP_006234528.1 reticulon-4 receptor-like 2 isoform X1

See identical proteins and their annotated locations for XP_006234528.1

UniProtKB/TrEMBL

A0A8L2QGV6, A6HMS3

Conserved Domains (4) summary

cd00116
Location:71 → 229

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:30 → 51

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:124 → 183

LRR_8; Leucine rich repeat

cl15307
Location:229 → 279

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain