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    Abca8a ATP-binding cassette, subfamily A (ABC1), member 8a [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303638, updated on 2-May-2024

    Summary

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    Official Symbol
    Abca8aprovided by RGD
    Official Full Name
    ATP-binding cassette, subfamily A (ABC1), member 8aprovided by RGD
    Primary source
    RGD:1307333
    See related
    Ensembl:ENSRNOG00000004147 AllianceGenome:RGD:1307333
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity and lipid transporter activity. Predicted to be involved in lipid transport. Predicted to be integral component of membrane. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human ABCA8 (ATP binding cassette subfamily A member 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 582.0), Muscle (RPKM 530.6) and 8 other tissues See more
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    Genomic context

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    See Abca8a in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (95501798..95571770, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (95002334..95072315, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (98319480..98390484, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L23a, pseudogene 1 Neighboring gene ATP binding cassette subfamily A member 8 Neighboring gene ATP binding cassette subfamily A member 9 Neighboring gene ATP binding cassette subfamily A member 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in lipid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP-binding cassette sub-family A member 8-A
    Names
    ATP-binding cassette, sub-family A (ABC1), member 8a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001281824.1 → NP_001268753.1  ATP-binding cassette sub-family A member 8-A

      See identical proteins and their annotated locations for NP_001268753.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      D3ZCF8
      Related
      ENSRNOP00000005665.6, ENSRNOT00000005665.7
      Conserved Domains (5) summary
      TIGR01188
      Location:493 → 787
      drrA; daunorubicin resistance ABC transporter ATP-binding subunit
      cd03263
      Location:1279 → 1500
      ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
      COG1131
      Location:1272 → 1591
      CcmA; ABC-type multidrug transport system, ATPase component [Defense mechanisms]
      pfam12698
      Location:27 → 416
      ABC2_membrane_3; ABC-2 family transporter protein
      pfam13664
      Location:267 → 354
      DUF4149; Domain of unknown function (DUF4149)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      95501798..95571770 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247611.5 → XP_006247673.1  ATP-binding cassette sub-family A member 8-A isoform X1

      See identical proteins and their annotated locations for XP_006247673.1

      UniProtKB/TrEMBL
      D3ZCF8
      Related
      ENSRNOP00000059943.4
      Conserved Domains (5) summary
      TIGR01188
      Location:493 → 787
      drrA; daunorubicin resistance ABC transporter ATP-binding subunit
      cd03263
      Location:1279 → 1500
      ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
      COG1131
      Location:1272 → 1591
      CcmA; ABC-type multidrug transport system, ATPase component [Defense mechanisms]
      pfam12698
      Location:27 → 416
      ABC2_membrane_3; ABC-2 family transporter protein
      pfam13664
      Location:267 → 354
      DUF4149; Domain of unknown function (DUF4149)

    2. XM_063269226.1 → XP_063125296.1  ATP-binding cassette sub-family A member 8-A isoform X2

    RNA

    1. XR_005489862.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.