U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Tmem33 transmembrane protein 33 [ Mus musculus (house mouse) ]

    Gene ID: 67878, updated on 30-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Tmem33provided by MGI
    Official Full Name
    transmembrane protein 33provided by MGI
    Primary source
    MGI:MGI:1915128
    See related
    Ensembl:ENSMUSG00000037720 AllianceGenome:MGI:1915128
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    db83; 1110006G02Rik; 1600019D15Rik; 2410089A21Rik; 2700052H22Rik; 5430406L04Rik
    Summary
    Predicted to be involved in several processes, including endoplasmic reticulum tubular network organization; positive regulation of endoplasmic reticulum unfolded protein response; and regulation of endoplasmic reticulum tubular network organization. Predicted to be located in endoplasmic reticulum membrane; melanosome; and nuclear envelope. Predicted to be integral component of endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including central nervous system; nasal cavity epithelium; retina; submandibular gland primordium; and trigeminal nerve. Orthologous to human TMEM33 (transmembrane protein 33). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 12.1), whole brain E14.5 (RPKM 11.3) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    5 C3.1; 5 36.0 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (67417908..67448804)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (67260565..67291461)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr5:67623014-67623314 Neighboring gene predicted gene, 33293 Neighboring gene predicted gene, 40314 Neighboring gene STARR-positive B cell enhancer ABC_E3579 Neighboring gene STARR-seq mESC enhancer starr_13313 Neighboring gene CRISPRi-validated cis-regulatory element for Bend4 and Slc30a9 Neighboring gene solute carrier family 30 (zinc transporter), member 9 Neighboring gene STARR-seq mESC enhancer starr_13315 Neighboring gene STARR-seq mESC enhancer starr_13316 Neighboring gene BEN domain containing 4 Neighboring gene predicted gene, 33345

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells. Arhatte M, et al. Nat Commun, 2019 May 2. PMID 31048699, Free PMC Article
    2. Elucidation of the 14-3-3ζ interactome reveals critical roles of RNA-splicing factors during adipogenesis. Mugabo Y, et al. J Biol Chem, 2018 May 4. PMID 29530978, Free PMC Article
    3. Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells. Zhang M, et al. Mol Cell Proteomics, 2014 Nov. PMID 25044020, Free PMC Article
    4. Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub. Forrest MP, et al. Nat Commun, 2023 Feb 17. PMID 36808153, Free PMC Article
    5. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (4) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in endoplasmic reticulum tubular network organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of IRE1-mediated unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of PERK-mediated unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of endoplasmic reticulum tubular network organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in melanosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    transmembrane protein 33

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285452.1 → NP_001272381.1  transmembrane protein 33 isoform 1

      See identical proteins and their annotated locations for NP_001272381.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. Variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AC102896, AK005493, AK012413, AK139978, AK165369, CJ103460
      Consensus CDS
      CCDS19317.1
      UniProtKB/Swiss-Prot
      Q544Q3, Q9CR67, Q9D3M3, Q9DAV4
      Related
      ENSMUSP00000124390.2, ENSMUST00000161369.3
      Conserved Domains (1) summary
      pfam03661
      Location:9 → 245
      UPF0121; Uncharacterized protein family (UPF0121)

    2. NM_028975.4 → NP_083251.2  transmembrane protein 33 isoform 1

      See identical proteins and their annotated locations for NP_083251.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AC102896, AK012413, AK017281, AK139978, AK165369
      Consensus CDS
      CCDS19317.1
      UniProtKB/Swiss-Prot
      Q544Q3, Q9CR67, Q9D3M3, Q9DAV4
      Related
      ENSMUSP00000042852.6, ENSMUST00000037918.12
      Conserved Domains (1) summary
      pfam03661
      Location:9 → 245
      UPF0121; Uncharacterized protein family (UPF0121)

    3. NM_030108.2 → NP_084384.1  transmembrane protein 33 isoform 2

      See identical proteins and their annotated locations for NP_084384.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, the 3' coding region and the 3' UTR, compared to variant 3. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC102896, AK012413, AK017281, AK139978
      Consensus CDS
      CCDS51511.1
      UniProtKB/TrEMBL
      A0A0R4J1Z3
      Related
      ENSMUSP00000124766.2, ENSMUST00000160352.8
      Conserved Domains (1) summary
      pfam03661
      Location:9 → 245
      UPF0121; Uncharacterized protein family (UPF0121)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      67417908..67448804
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CR67.1 GenPept UniProtKB/Swiss-Prot:Q9CR67

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous