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    Lrrc15 leucine rich repeat containing 15 [ Mus musculus (house mouse) ]

    Gene ID: 74488, updated on 25-Apr-2024

    Summary

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    Official Symbol
    Lrrc15provided by MGI
    Official Full Name
    leucine rich repeat containing 15provided by MGI
    Primary source
    MGI:MGI:1921738
    See related
    Ensembl:ENSMUSG00000052316 AllianceGenome:MGI:1921738
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LIB; 5430427N11Rik
    Summary
    Predicted to enable collagen binding activity; fibronectin binding activity; and laminin binding activity. Predicted to be involved in negative regulation of protein localization to plasma membrane; positive regulation of cell migration; and receptor-mediated virion attachment to host cell. Predicted to be located in cell surface. Predicted to be active in extracellular matrix and extracellular space. Predicted to colocalize with collagen-containing extracellular matrix. Is expressed in several structures, including gonad; incisor; skin; submandibular gland; and trunk. Orthologous to human LRRC15 (leucine rich repeat containing 15). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in heart adult (RPKM 6.0), mammary gland adult (RPKM 2.2) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 B2; 16 21.23 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (30088120..30102072, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (30269302..30283254, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5535 Neighboring gene predicted gene, 33330 Neighboring gene carboxypeptidase N, polypeptide 2 Neighboring gene STARR-seq mESC enhancer starr_40574 Neighboring gene ATPase type 13A3 Neighboring gene glycoprotein 5 platelet Neighboring gene STARR-positive B cell enhancer mm9_chr16:30374407-30374708

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. LRRC15(+) myofibroblasts dictate the stromal setpoint to suppress tumour immunity. Krishnamurty AT, et al. Nature, 2022 Nov. PMID 36171287, Free PMC Article
    2. LRRC15 promotes osteogenic differentiation of mesenchymal stem cells by modulating p65 cytoplasmic/nuclear translocation. Wang Y, et al. Stem Cell Res Ther, 2018 Mar 9. PMID 29523191, Free PMC Article
    3. Transcriptomic and epigenomic analyses uncovered Lrrc15 as a contributing factor to cartilage damage in osteoarthritis. Singh P, et al. Sci Rep, 2021 Oct 26. PMID 34702854, Free PMC Article
    4. Identification of a DNA-binding site and transcriptional target for the EWS-WT1(+KTS) oncoprotein. Reynolds PA, et al. Genes Dev, 2003 Sep 1. PMID 12923058, Free PMC Article
    5. Mitochondrial retention of Opa1 is required for mouse embryogenesis. Moore BA, et al. Mamm Genome, 2010 Aug. PMID 20652258

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LRRC15(+) myofibroblasts dictate the stromal setpoint to suppress tumour immunity.
      Title: LRRC15(+) myofibroblasts dictate the stromal setpoint to suppress tumour immunity.
    2. Transcriptomic and epigenomic analyses uncovered Lrrc15 as a contributing factor to cartilage damage in osteoarthritis.
      Title: Transcriptomic and epigenomic analyses uncovered Lrrc15 as a contributing factor to cartilage damage in osteoarthritis.
    3. LRRC15 is an essential regulator for osteogenesis of mesenchymal stem cells through modulating p65 cytoplasmic/nuclear translocation.
      Title: LRRC15 promotes osteogenic differentiation of mesenchymal stem cells by modulating p65 cytoplasmic/nuclear translocation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables collagen binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fibronectin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables laminin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein sequestering activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of viral entry into host cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in receptor-mediated virion attachment to host cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with collagen-containing extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028973.2 → NP_083249.1  leucine-rich repeat-containing protein 15 precursor

      See identical proteins and their annotated locations for NP_083249.1

      Status: VALIDATED

      Source sequence(s)
      AK017350, BC050245, BX522800
      Consensus CDS
      CCDS28099.1
      UniProtKB/Swiss-Prot
      Q80X72
      Related
      ENSMUSP00000066777.8, ENSMUST00000064606.8
      Conserved Domains (3) summary
      smart00082
      Location:423 → 462
      LRRCT; Leucine rich repeat C-terminal domain
      PLN00113
      Location:82 → 401
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:127 → 150
      LRR_RI; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      30088120..30102072 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160172.1 → XP_036016065.1  leucine-rich repeat-containing protein 15 isoform X1

      UniProtKB/Swiss-Prot
      Q80X72
      Conserved Domains (3) summary
      smart00082
      Location:423 → 462
      LRRCT; Leucine rich repeat C-terminal domain
      PLN00113
      Location:82 → 401
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:127 → 150
      LRR_RI; leucine-rich repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80X72.1 GenPept UniProtKB/Swiss-Prot:Q80X72

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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