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    Cars1 cysteinyl-tRNA synthetase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293638, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cars1provided by RGD
    Official Full Name
    cysteinyl-tRNA synthetase 1provided by RGD
    Primary source
    RGD:1310747
    See related
    Ensembl:ENSRNOG00000020651 AllianceGenome:RGD:1310747
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cars
    Summary
    Predicted to enable several functions, including ATP binding activity; cysteine-tRNA ligase activity; and protein homodimerization activity. Predicted to be involved in cysteinyl-tRNA aminoacylation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human CARS1 (cysteinyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 143.9), Brain (RPKM 100.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    1q42
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (208183092..208225425, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (198753689..198796016, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (216759367..216801652, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene pleckstrin homology-like domain, family A, member 2 Neighboring gene nucleosome assembly protein 1-like 4 Neighboring gene small nucleolar RNA, H/ACA box 54 Neighboring gene uncharacterized LOC134483952 Neighboring gene transfer RNA valine (anticodon AAC) 16 Neighboring gene tumor necrosis factor receptor superfamily, member 26

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Kinetic quality control of anticodon recognition by a eukaryotic aminoacyl-tRNA synthetase. Liu C, et al. J Mol Biol, 2007 Apr 6. PMID 17303165, Free PMC Article
    2. Isolation of two cDNAs encoding functional human cytoplasmic cysteinyl-tRNA synthetase. Davidson E, et al. Biol Chem, 2001 Mar. PMID 11347887
    3. An elongation factor-associating domain is inserted into human cysteinyl-tRNA synthetase by alternative splicing. Kim JE, et al. Nucleic Acids Res, 2000 Aug 1. PMID 10908348, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cysteinyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cysteinyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cysteine--tRNA ligase, cytoplasmic
    Names
    cysteinyl-tRNA synthetase, cytoplasmic
    NP_001099789.1
    XP_006230775.1
    XP_038964041.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106319.1 → NP_001099789.1  cysteine--tRNA ligase, cytoplasmic

      See identical proteins and their annotated locations for NP_001099789.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473953
      UniProtKB/TrEMBL
      A0A8I6AVG0, A6HYC5, G3V9K0
      Related
      ENSRNOP00000050342.2, ENSRNOT00000050721.4
      Conserved Domains (2) summary
      cd00672
      Location:30 → 445
      CysRS_core; catalytic core domain of cysteinyl tRNA synthetase
      PTZ00399
      Location:1 → 745
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      208183092..208225425 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230713.5 → XP_006230775.1  cysteine--tRNA ligase, cytoplasmic isoform X1

      See identical proteins and their annotated locations for XP_006230775.1

      UniProtKB/TrEMBL
      A0A8I5Y9V4, A0A8I6AVG0, A6HYC6
      Related
      ENSRNOP00000078006.1
      Conserved Domains (3) summary
      cd00672
      Location:113 → 528
      CysRS_core; catalytic core domain of cysteinyl tRNA synthetase
      cd10310
      Location:4 → 76
      GST_C_CysRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of Cysteinyl-tRNA synthetase from higher eukaryotes
      PTZ00399
      Location:91 → 828
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional

    2. XM_039108113.2 → XP_038964041.1  cysteine--tRNA ligase, cytoplasmic isoform X2

      UniProtKB/TrEMBL
      A0A8I6AVG0
      Conserved Domains (1) summary
      PTZ00399
      Location:1 → 681
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version

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