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    Fnbp1 formin binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 192348, updated on 13-Apr-2024

    Summary

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    Symbol
    Fnbp1provided by RGD
    Full Name
    formin binding protein 1provided by RGD
    Primary source
    RGD:621350
    See related
    Ensembl:ENSRNOG00000008258 AllianceGenome:RGD:621350
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity. Involved in nervous system development. Predicted to be located in intracellular membrane-bounded organelle and plasma membrane. Orthologous to human FNBP1 (formin binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 85.2), Thymus (RPKM 52.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fnbp1 in Genome Data Viewer
    Location:
    3p12
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (34706814..34826770, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (14309067..14424378, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (9865657..9936333, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 9 open reading frame 78 Neighboring gene ubiquitin specific peptidase 20 Neighboring gene U12 minor spliceosomal RNA Neighboring gene G protein-coupled receptor 107 Neighboring gene ATP synthase F(0) complex subunit C2, mitochondrial-like Neighboring gene neuronal calcium sensor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. In vivo function of Rnd2 in the development of neocortical pyramidal neurons. Nakamura K, et al. Neurosci Res, 2006 Feb. PMID 16303198
    2. The F-BAR protein Rapostlin regulates dendritic spine formation in hippocampal neurons. Wakita Y, et al. J Biol Chem, 2011 Sep 16. PMID 21768103, Free PMC Article
    3. Rapostlin is a novel effector of Rnd2 GTPase inducing neurite branching. Fujita H, et al. J Biol Chem, 2002 Nov 22. PMID 12244061
    4. Curved EFC/F-BAR-domain dimers are joined end to end into a filament for membrane invagination in endocytosis. Shimada A, et al. Cell, 2007 May 18. PMID 17512409
    5. The regulatory subunit of PDE6 interacts with PACSIN in photoreceptors. Houdart F, et al. Mol Vis, 2005 Dec 9. PMID 16357825

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. F-BAR protein Rapostlin, whose activity is regulated by Rnd2, plays a key role in spine formation through the regulation of membrane dynamics.
      Title: The F-BAR protein Rapostlin regulates dendritic spine formation in hippocampal neurons.
    2. Data show that rapostlin is the first effector of Rnd2, regulating neurite branch formation.
      Title: Rapostlin is a novel effector of Rnd2 GTPase inducing neurite branching.
    3. Rnd2 functions in vivo as a regulator of the migration and morphological changes associated with the development of pyramidal neurons
      Title: In vivo function of Rnd2 in the development of neocortical pyramidal neurons.
    4. functionally different splicing variants of Rapostlin have different responses to Rnd2 in association with N-WASP.
      Title: Identification of splicing variants of Rapostlin, a novel RND2 effector that interacts with neural Wiskott-Aldrich syndrome protein and induces neurite branching.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nervous system development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    formin-binding protein 1
    Names
    formin-binding protein 1-like
    formin-binding protein 17
    rapostlin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393677.1 → NP_001380606.1  formin-binding protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q75UE2, Q75UE3, Q75UE4, Q75UE5, Q75UE6, Q8R511
      UniProtKB/TrEMBL
      Z4YNH5
      Related
      ENSRNOP00000077955.1, ENSRNOT00000119171.1
      Conserved Domains (3) summary
      cd07676
      Location:5 → 257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cd11629
      Location:406 → 482
      HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
      cd12071
      Location:552 → 608
      SH3_FBP17; Src Homology 3 domain of Formin Binding Protein 17

    2. NM_001393678.1 → NP_001380607.1  formin-binding protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      Z4YNH5
      Related
      ENSRNOP00000049838.6, ENSRNOT00000042798.7
      Conserved Domains (3) summary
      cd07676
      Location:5 → 257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cd11629
      Location:401 → 477
      HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
      cl17036
      Location:547 → 603
      SH3; Src Homology 3 domain superfamily

    3. NM_001393679.1 → NP_001380608.1  formin-binding protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6A8B9
      Conserved Domains (3) summary
      cl00087
      Location:377 → 453
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl12013
      Location:5 → 257
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl17036
      Location:523 → 579
      SH3; Src Homology 3 domain superfamily

    4. NM_001393680.1 → NP_001380609.1  formin-binding protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6A8B9
      Conserved Domains (3) summary
      cl00087
      Location:372 → 448
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl12013
      Location:5 → 257
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl17036
      Location:518 → 574
      SH3; Src Homology 3 domain superfamily

    5. NM_001393681.1 → NP_001380610.1  formin-binding protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6A8B9
      Conserved Domains (3) summary
      cl00087
      Location:345 → 421
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl12013
      Location:5 → 257
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl17036
      Location:491 → 547
      SH3; Src Homology 3 domain superfamily

    6. NM_001393682.1 → NP_001380611.1  formin-binding protein 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6A8B9
      Conserved Domains (3) summary
      cl00087
      Location:340 → 416
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl12013
      Location:5 → 257
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl17036
      Location:486 → 542
      SH3; Src Homology 3 domain superfamily

    7. NM_138914.2 → NP_620269.1  formin-binding protein 1 isoform 1

      See identical proteins and their annotated locations for NP_620269.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      Z4YNH5
      Conserved Domains (3) summary
      cd07676
      Location:5 → 257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cd11629
      Location:406 → 482
      HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
      cd12071
      Location:552 → 608
      SH3_FBP17; Src Homology 3 domain of Formin Binding Protein 17

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      34706814..34826770 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283065.1 → XP_063139135.1  formin-binding protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8I6AH08

    2. XM_063283060.1 → XP_063139130.1  formin-binding protein 1 isoform X3

    3. XM_063283064.1 → XP_063139134.1  formin-binding protein 1 isoform X7

    4. XM_063283061.1 → XP_063139131.1  formin-binding protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6GFT9

    5. XM_063283070.1 → XP_063139140.1  formin-binding protein 1 isoform X13

      UniProtKB/TrEMBL
      A0A8I6AD72

    6. XM_063283071.1 → XP_063139141.1  formin-binding protein 1 isoform X14

    7. XM_063283068.1 → XP_063139138.1  formin-binding protein 1 isoform X11

      UniProtKB/TrEMBL
      A0A8I5ZUF2

    8. XM_063283067.1 → XP_063139137.1  formin-binding protein 1 isoform X10

    9. XM_063283058.1 → XP_063139128.1  formin-binding protein 1 isoform X1

    10. XM_063283069.1 → XP_063139139.1  formin-binding protein 1 isoform X12

    11. XM_063283066.1 → XP_063139136.1  formin-binding protein 1 isoform X9

    12. XM_063283063.1 → XP_063139133.1  formin-binding protein 1 isoform X6

    13. XM_063283062.1 → XP_063139132.1  formin-binding protein 1 isoform X5

    14. XM_063283059.1 → XP_063139129.1  formin-binding protein 1 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R511.2 GenPept UniProtKB/Swiss-Prot:Q8R511

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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