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    Esrrg estrogen-related receptor gamma [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360896, updated on 19-Jun-2024

    Summary

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    Official Symbol
    Esrrgprovided by RGD
    Official Full Name
    estrogen-related receptor gammaprovided by RGD
    Primary source
    RGD:1303236
    See related
    Ensembl:ENSRNOG00000002593 AllianceGenome:RGD:1303236
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    errg
    Summary
    Predicted to enable several functions, including AF-2 domain binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and identical protein binding activity. Predicted to be involved in positive regulation of cold-induced thermogenesis and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human ESRRG (estrogen related receptor gamma). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 75.2), Heart (RPKM 50.1) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Esrrg in Genome Data Viewer
    Location:
    13q26
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (101699043..102316877)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (99167656..99788016)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (106063799..106683353)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553391 Neighboring gene large ribosomal subunit protein eL29-like Neighboring gene uncharacterized LOC120096194 Neighboring gene uncharacterized LOC120096195 Neighboring gene uncharacterized LOC120096344 Neighboring gene usherin Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Estrogen receptor-related receptor gamma has an exceptionally broad specificity of DNA sequence recognition. Razzaque MA, et al. Gene, 2004 Oct 13. PMID 15475169
    2. Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression. Zhang Y, et al. J Biol Chem, 2006 Dec 29. PMID 17079227
    3. Requirements for transcriptional regulation by the orphan nuclear receptor ERRgamma. Huppunen J, et al. Mol Cell Endocrinol, 2004 Apr 30. PMID 15149736
    4. Role of Estrogen-Related Receptor γ and PGC-1α/SIRT3 Pathway in Early Brain Injury After Subarachnoid Hemorrhage. Guo Y, et al. Neurotherapeutics, 2023 Apr. PMID 36481985, Free PMC Article
    5. ERRγ enhances UCP1 expression and fatty acid oxidation in brown adipocytes. Dixen K, et al. Obesity (Silver Spring), 2013 Mar. PMID 23404793

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Role of Estrogen-Related Receptor gamma and PGC-1alpha/SIRT3 Pathway in Early Brain Injury After Subarachnoid Hemorrhage.
      Title: Role of Estrogen-Related Receptor γ and PGC-1α/SIRT3 Pathway in Early Brain Injury After Subarachnoid Hemorrhage.
    2. ERRgamma plays a key role in vascular calcification by upregulating the BMP2 signaling pathway.
      Title: Estrogen-Related Receptor γ Plays a Key Role in Vascular Calcification Through the Upregulation of BMP2 Expression.
    3. ERRgamma was preferentially expressed in brown compared to white fat depots, and ERRgamma was induced during cold-induced browning of subcutaneous white adipose tissue and brown adipogenesis
      Title: ERRγ enhances UCP1 expression and fatty acid oxidation in brown adipocytes.
    4. Estrogen-related receptor gamma (ERRgamma) is a novel transcriptional regulator of phosphatidic acid phosphatase, LIPIN1, and inhibits hepatic insulin signaling
      Title: Estrogen-related receptor γ (ERRγ) is a novel transcriptional regulator of phosphatidic acid phosphatase, LIPIN1, and inhibits hepatic insulin signaling.
    5. ERRgamma recognizes a tremendously broad range of sequences as a homodimer.
      Title: Estrogen receptor-related receptor gamma has an exceptionally broad specificity of DNA sequence recognition.
    6. Estrogen-related receptor gamma binds to the hepatic pyruvate dehydrogenase kinase (PDK) 4 promoter and stimulates PDK4 expression.
      Title: Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables AF-2 domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables estrogen response element binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables estrogen response element binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear steroid receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables steroid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nuclear receptor-mediated steroid hormone signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retinoic acid receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in steroid hormone receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    estrogen-related receptor gamma
    Names
    estrogen receptor-related protein 3
    nuclear receptor subfamily 3 group B member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401443.1 → NP_001388372.1  estrogen-related receptor gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      P62510, Q5QJE4, Q75T51, Q75T52
      UniProtKB/TrEMBL
      A0A8I6A6X6, A6JGT8
      Related
      ENSRNOP00000003489.3, ENSRNOT00000003489.5

    2. NM_001415123.1 → NP_001402052.1  estrogen-related receptor gamma isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A8I6A6X6, A6JGU0

    3. NM_001415124.1 → NP_001402053.1  estrogen-related receptor gamma isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A8I6A6X6, A6JGU0

    4. NM_203336.3 → NP_976081.1  estrogen-related receptor gamma isoform 2

      See identical proteins and their annotated locations for NP_976081.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A8I6A6X6, A6JGU0
      Conserved Domains (2) summary
      cd06946
      Location:214 → 433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99 → 195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      101699043..102316877
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272510.1 → XP_063128580.1  estrogen-related receptor gamma isoform X1

      UniProtKB/TrEMBL
      A0A8I6A6X6, A6JGU0

    2. XM_017598866.3 → XP_017454355.1  estrogen-related receptor gamma isoform X1

      UniProtKB/TrEMBL
      A0A8I6A6X6, A6JGU0
      Conserved Domains (2) summary
      cd06946
      Location:214 → 433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99 → 195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    3. XM_039090940.2 → XP_038946868.1  estrogen-related receptor gamma isoform X1

      UniProtKB/TrEMBL
      A0A8I6A6X6, A6JGU0
      Conserved Domains (2) summary
      cd06946
      Location:214 → 433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99 → 195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    4. XM_063272511.1 → XP_063128581.1  estrogen-related receptor gamma isoform X1

      UniProtKB/TrEMBL
      A0A8I6A6X6, A6JGU0

    5. XM_063272509.1 → XP_063128579.1  estrogen-related receptor gamma isoform X1

      UniProtKB/TrEMBL
      A0A8I6A6X6, A6JGU0

    6. XM_063272508.1 → XP_063128578.1  estrogen-related receptor gamma isoform X1

      UniProtKB/TrEMBL
      A0A8I6A6X6, A6JGU0

    7. XM_039090941.2 → XP_038946869.1  estrogen-related receptor gamma isoform X1

      UniProtKB/TrEMBL
      A0A8I6A6X6, A6JGU0
      Conserved Domains (2) summary
      cd06946
      Location:214 → 433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99 → 195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62510.1 GenPept UniProtKB/Swiss-Prot:P62510

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