fcho2 FCH and mu domain containing endocytic adaptor 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fcho2provided by ZNC
Official Full Name: FCH and mu domain containing endocytic adaptor 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-050522-228
See related: Ensembl:ENSDARG00000035389 AllianceGenome:ZFIN:ZDB-GENE-050522-228
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb304; sb:cb304; wu:fa01a02; zgc:112167; si:ch211-195c22.1
Summary: Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity and phosphatidylserine binding activity. Acts upstream of or within chordate embryonic development. Predicted to be located in membrane. Predicted to be active in clathrin-coated pit and clathrin-coated vesicle. Is expressed in anterior axial hypoblast; hatching gland; immature eye; polster; and yolk syncytial layer. Orthologous to human FCHO2 (FCH and mu domain containing endocytic adaptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (35123662..35200808, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (34523509..34600720, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

G46052 (e-PCR)
- UniSTS:106854

fa01a02.s1 (e-PCR)
- UniSTS:202108

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables phosphatidylinositol-4,5-bisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylserine binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chordate embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in clathrin coat assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in clathrin coat assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in clathrin-dependent endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in clathrin-dependent endocytosis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within convergent extension involved in axis elongation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within endocytosis	IEA Inferred from Electronic Annotation more info
involved_in membrane invagination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in synaptic vesicle endocytosis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in clathrin-coated pit	IBA Inferred from Biological aspect of Ancestor more info
located_in clathrin-coated pit	IEA Inferred from Electronic Annotation more info
located_in clathrin-coated pit	ISS Inferred from Sequence or Structural Similarity more info
is_active_in clathrin-coated vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: F-BAR domain only protein 2

Names: FCH domain only 2; FCH domain only protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001020781.2 → NP_001018617.2 F-BAR domain only protein 2

Status: VALIDATED

Source sequence(s)

CR377210, CR751565

Related

ENSDARP00000051270.5, ENSDART00000051271.7

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007116.7 Reference GRCz11 Primary Assembly

Range

35123662..35200808 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021476160.1 → XP_021331835.1 F-BAR domain only protein 2 isoform X1

UniProtKB/TrEMBL

A0A8M9QDY0

Conserved Domains (3) summary

cd07673
Location:5 → 273

F-BAR_FCHO2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 2 protein

cl10970
Location:793 → 1059

AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

cl26464
Location:483 → 720

Atrophin-1; Atrophin-1 family
XM_021476162.1 → XP_021331837.1 F-BAR domain only protein 2 isoform X3

UniProtKB/TrEMBL

A0A8M9PK46

Conserved Domains (3) summary

cd07673
Location:5 → 273

F-BAR_FCHO2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 2 protein

cl10970
Location:777 → 1043

AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

cl26464
Location:467 → 704

Atrophin-1; Atrophin-1 family
XM_005171862.4 → XP_005171919.1 F-BAR domain only protein 2 isoform X7

UniProtKB/TrEMBL

A0A8M2BJ82

Conserved Domains (2) summary

cd07673
Location:5 → 273

F-BAR_FCHO2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 2 protein

cl10970
Location:752 → 1018

AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
XM_021476161.1 → XP_021331836.1 F-BAR domain only protein 2 isoform X2

UniProtKB/TrEMBL

A0A8M9Q8L9

Conserved Domains (3) summary

cd07673
Location:5 → 273

F-BAR_FCHO2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 2 protein

cl10970
Location:778 → 1044

AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

cl26464
Location:468 → 705

Atrophin-1; Atrophin-1 family
XM_021476164.1 → XP_021331839.1 F-BAR domain only protein 2 isoform X9

UniProtKB/TrEMBL

A0A8M9Q3B6

Conserved Domains (2) summary

cd07673
Location:5 → 273

F-BAR_FCHO2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 2 protein

cl10970
Location:596 → 862

AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
XM_009301491.3 → XP_009299766.1 F-BAR domain only protein 2 isoform X10

UniProtKB/TrEMBL

A0A8M3B9M8

Related

ENSDARP00000141294.2, ENSDART00000166272.2

Conserved Domains (2) summary

cd07673
Location:5 → 273

F-BAR_FCHO2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 2 protein

cl10970
Location:577 → 843

AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
XM_009301489.3 → XP_009299764.1 F-BAR domain only protein 2 isoform X8

UniProtKB/TrEMBL

A0A8M3ASB7

Conserved Domains (2) summary

cd07673
Location:5 → 273

F-BAR_FCHO2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 2 protein

cl10970
Location:597 → 863

AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
XM_009301485.3 → XP_009299760.1 F-BAR domain only protein 2 isoform X6

UniProtKB/TrEMBL

A0A8M3AZM0

Conserved Domains (2) summary

cd07673
Location:5 → 273

F-BAR_FCHO2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 2 protein

cl10970
Location:767 → 1033

AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
XM_009301484.3 → XP_009299759.1 F-BAR domain only protein 2 isoform X5

UniProtKB/TrEMBL

A0A8M3B2H5

Conserved Domains (2) summary

cd07673
Location:5 → 273

F-BAR_FCHO2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 2 protein

cl10970
Location:768 → 1034

AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
XM_021476163.1 → XP_021331838.1 F-BAR domain only protein 2 isoform X4

UniProtKB/TrEMBL

A0A8M9PXK6

Conserved Domains (3) summary

cd07673
Location:5 → 273

F-BAR_FCHO2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 2 protein

cl10970
Location:773 → 1039

AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

cl26464
Location:485 → 728

Atrophin-1; Atrophin-1 family