ecsit ECSIT signaling integrator [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ecsitprovided by ZNC
Official Full Name: ECSIT signaling integratorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-1332
See related: Ensembl:ENSDARG00000062834 AllianceGenome:ZFIN:ZDB-GENE-030131-1332
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sitpec; fd13d06; wu:fb67e08; wu:fd13d06; zgc:152999
Summary: Predicted to be involved in regulation of oxidoreductase activity and regulation of protein complex stability. Predicted to act upstream of or within innate immune response. Predicted to be located in cytoplasm and nucleus. Predicted to be active in mitochondrion. Orthologous to human ECSIT (ECSIT signaling integrator). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (17805324..17816195, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (17553349..17564222, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fd13d06.x1 (e-PCR)
- UniSTS:204144

fb67e03 (e-PCR)
- UniSTS:189071

fc65g09.y1 (e-PCR)
- UniSTS:194206

AI558881 (e-PCR)
- UniSTS:206253

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in cell surface receptor protein serine/threonine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

Names: ECSIT homolog; ECSIT signalling integrator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001242938.1 → NP_001229867.1 evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

See identical proteins and their annotated locations for NP_001229867.1

Status: VALIDATED

Source sequence(s)

BM316149, DY551107, EH486163, EH600372

UniProtKB/Swiss-Prot

Q08CK1

UniProtKB/TrEMBL

A0A8M1NZ30, F1QSV0

Related

ENSDARP00000085705.4, ENSDART00000091272.6

Conserved Domains (3) summary

sd00004
Location:102 → 133

PPR; PPR repeat [structural motif]

pfam06239
Location:61 → 279

ECSIT; Evolutionarily conserved signalling intermediate in Toll pathway

pfam14784
Location:282 → 411

ECIST_C; C-terminal domain of the ECSIT protein

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

17805324..17816195 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009302997.3 → XP_009301272.1 evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1

See identical proteins and their annotated locations for XP_009301272.1

UniProtKB/Swiss-Prot

Q08CK1

UniProtKB/TrEMBL

A0A8M1NZ30, F1QSV0

Related

ENSDARP00000124710.1, ENSDART00000149821.4

Conserved Domains (3) summary

sd00004
Location:102 → 133

PPR; PPR repeat [structural motif]

pfam06239
Location:61 → 279

ECSIT; Evolutionarily conserved signalling intermediate in Toll pathway

pfam14784
Location:282 → 411

ECIST_C; C-terminal domain of the ECSIT protein