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    Catsper2 cation channel, sperm associated 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366174, updated on 2-May-2024

    Summary

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    Official Symbol
    Catsper2provided by RGD
    Official Full Name
    cation channel, sperm associated 2provided by RGD
    Primary source
    RGD:1307620
    See related
    Ensembl:ENSRNOG00000023064 AllianceGenome:RGD:1307620
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium activated cation channel activity; calcium channel activity; and voltage-gated ion channel activity. Predicted to be involved in fertilization; flagellated sperm motility; and sperm capacitation. Predicted to be located in sperm flagellum. Predicted to be part of CatSper complex. Orthologous to human CATSPER2 (cation channel sperm associated 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 133.8), Kidney (RPKM 16.5) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Catsper2 in Genome Data Viewer
    Location:
    3q35
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (128822387..128842501, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (108368654..108389380, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (113357361..113379498, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene diphosphoinositol pentakisphosphate kinase 1 Neighboring gene creatine kinase, mitochondrial 1 Neighboring gene stereocilin Neighboring gene protein disulfide isomerase family A, member 3 Neighboring gene U6 spliceosomal RNA Neighboring gene RNA, U105C small nucleolar

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Regulation of fertilization in male rats by CatSper2 knockdown. Zhang Z, et al. Asian J Androl, 2012 Mar. PMID 22002435, Free PMC Article
    2. Hyperactivated sperm motility driven by CatSper2 is required for fertilization. Quill TA, et al. Proc Natl Acad Sci U S A, 2003 Dec 9. PMID 14657366, Free PMC Article
    3. The effect of clomiphene citrate and human chorionic gonadotropin on the expression of CatSper1, CatSper2, LHCGR, and SF1 genes, as well as the structural changes in testicular tissue of adult rats. Ameli M, et al. Mol Reprod Dev, 2019 Jun. PMID 31041823
    4. Contributions of extracellular and intracellular Ca2+ to regulation of sperm motility: Release of intracellular stores can hyperactivate CatSper1 and CatSper2 null sperm. Marquez B, et al. Dev Biol, 2007 Mar 1. PMID 17174296, Free PMC Article
    5. A voltage-gated ion channel expressed specifically in spermatozoa. Quill TA, et al. Proc Natl Acad Sci U S A, 2001 Oct 23. PMID 11675491, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The effect of clomiphene citrate and human chorionic gonadotropin on the expression of CatSper1, CatSper2, LHCGR, and SF1 genes, as well as the structural changes in testicular tissue of adult rats.
      Title: The effect of clomiphene citrate and human chorionic gonadotropin on the expression of CatSper1, CatSper2, LHCGR, and SF1 genes, as well as the structural changes in testicular tissue of adult rats.
    2. It is feasible to achieve male contraception by silencing the expression of CatSper2, the key protein involved in sperm hyperactivation.
      Title: Regulation of fertilization in male rats by CatSper2 knockdown.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-activated cation channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables voltage-gated calcium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in calcium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fertilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within fertilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in flagellated sperm motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in flagellated sperm motility IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sperm capacitation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sperm capacitation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of CatSper complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CatSper complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of CatSper complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of CatSper complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cation channel sperm-associated protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012220.1 → NP_001012220.1  cation channel sperm-associated protein 2

      See identical proteins and their annotated locations for NP_001012220.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079422
      UniProtKB/Swiss-Prot
      Q6AXP6
      UniProtKB/TrEMBL
      A0A8I5ZML1, A6HPN9
      Related
      ENSRNOP00000038712.3, ENSRNOT00000030019.4
      Conserved Domains (2) summary
      pfam00183
      Location:419 → 463
      HSP90; Hsp90 protein
      pfam00520
      Location:138 → 348
      Ion_trans; Ion transport protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      128822387..128842501 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017591949.3 → XP_017447438.1  cation channel sperm-associated protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q6AXP6
      UniProtKB/TrEMBL
      A0A8I5ZML1, A6HPN9
      Conserved Domains (2) summary
      pfam00183
      Location:419 → 463
      HSP90; Hsp90 protein
      pfam00520
      Location:138 → 348
      Ion_trans; Ion transport protein

    2. XM_063284284.1 → XP_063140354.1  cation channel sperm-associated protein 2 isoform X2

    3. XM_008762187.4 → XP_008760409.1  cation channel sperm-associated protein 2 isoform X1

      See identical proteins and their annotated locations for XP_008760409.1

      UniProtKB/Swiss-Prot
      Q6AXP6
      UniProtKB/TrEMBL
      A0A8I5ZML1, A6HPN9
      Conserved Domains (2) summary
      pfam00183
      Location:419 → 463
      HSP90; Hsp90 protein
      pfam00520
      Location:138 → 348
      Ion_trans; Ion transport protein

    4. XM_006234860.4 → XP_006234922.1  cation channel sperm-associated protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZML1
      Conserved Domains (2) summary
      pfam00183
      Location:379 → 423
      HSP90; Hsp90 protein
      pfam00520
      Location:146 → 308
      Ion_trans; Ion transport protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AXP6.1 GenPept UniProtKB/Swiss-Prot:Q6AXP6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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