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    Mecom MDS1 and EVI1 complex locus [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294924, updated on 6-Jun-2024

    Summary

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    Symbol
    Mecomprovided by RGD
    Full Name
    MDS1 and EVI1 complex locusprovided by RGD
    Primary source
    RGD:1310997
    See related
    Ensembl:ENSRNOG00000012645 AllianceGenome:RGD:1310997
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Evi1; Mds1
    Summary
    Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; histone methyltransferase activity (H3-K9 specific); and protein homodimerization activity. Predicted to be involved in several processes, including hematopoietic stem cell proliferation; negative regulation of JNK cascade; and regulation of transcription, DNA-templated. Predicted to act upstream of or within several processes, including animal organ development; embryonic limb morphogenesis; and positive regulation of brown fat cell differentiation. Predicted to be located in nuclear speck. Predicted to be part of histone deacetylase complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in myeloid neoplasm. Orthologous to human MECOM (MDS1 and EVI1 complex locus). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 186.7), Lung (RPKM 131.7) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mecom in Genome Data Viewer
    Location:
    2q24
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (114837815..115393052)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (112909353..113464583)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (117396084..117993604, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100572 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134485612 Neighboring gene EGF-like and EMI domain containing 1 Neighboring gene uncharacterized LOC134485895 Neighboring gene microRNA 551b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Suppression of Evi1 promotes the osteogenic differentiation and inhibits the adipogenic differentiation of bone marrow-derived mesenchymal stem cells in vitro. An Q, et al. Int J Mol Med, 2015 Dec. PMID 26497332
    2. Evi1 is a survival factor which conveys resistance to both TGFbeta- and taxol-mediated cell death via PI3K/AKT. Liu Y, et al. Oncogene, 2006 Jun 15. PMID 16462766
    3. Fusion of ETV6 to MDS1/EVI1 as a result of t(3;12)(q26;p13) in myeloproliferative disorders. Peeters P, et al. Cancer Res, 1997 Feb 15. PMID 9044825
    4. Identification, nuclear localization, and DNA-binding activity of the zinc finger protein encoded by the Evi-1 myeloid transforming gene. Matsugi T, et al. Mol Cell Biol, 1990 Mar. PMID 2106070, Free PMC Article
    5. Zinc fingers 1-7 of EVI1 fail to bind to the GATA motif by itself but require the core site GACAAGATA for binding. Perkins AS, et al. J Biol Chem, 1996 Jan 12. PMID 8557637

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that the ectopic viral integration site1 (Evi1) gene may be targeted as a therapeutic strategy for promoting bone formation.
      Title: Suppression of Evi1 promotes the osteogenic differentiation and inhibits the adipogenic differentiation of bone marrow-derived mesenchymal stem cells in vitro.
    2. Evi1 functions as a survival gene in intestinal epithelial cells and colon cancer cells
      Title: Evi1 is a survival factor which conveys resistance to both TGFbeta- and taxol-mediated cell death via PI3K/AKT.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H3K9 methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within embryonic forelimb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic hindlimb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within forebrain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hematopoietic stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heterochromatin organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within maintenance of cell number ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neutrophil homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within pericardium development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of brown fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within post-embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of hematopoietic stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ureter morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of histone deacetylase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase MECOM
    Names
    MDS1 and EVI1 complex locus protein EVI1
    MDS1 and EVI1 complex locus protein MDS1
    ecotropic viral integration site 1
    myelodysplasia syndrome 1 homolog
    NP_001376211.1
    XP_006232311.1
    XP_006232312.1
    XP_038957898.1
    XP_038957899.1
    XP_038957900.1
    XP_038957901.1
    XP_038957902.1
    XP_038957903.1
    XP_038957904.1
    XP_063137620.1
    XP_063137621.1
    XP_063137622.1
    XP_063137623.1
    XP_063137624.1
    XP_063137625.1
    XP_063137626.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001389282.2 → NP_001376211.1  histone-lysine N-methyltransferase MECOM

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6GM83
      Conserved Domains (6) summary
      PHA00733
      Location:881 → 977
      PHA00733; hypothetical protein
      COG5189
      Location:347 → 399
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:927 → 947
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl40432
      Location:50 → 207
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
      pfam00096
      Location:925 → 947
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:939 → 963
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      114837815..115393052
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101974.2 → XP_038957902.1  histone-lysine N-methyltransferase MECOM isoform X5

      UniProtKB/TrEMBL
      A0A8I6AF72
      Conserved Domains (6) summary
      PHA00733
      Location:881 → 977
      PHA00733; hypothetical protein
      COG5189
      Location:305 → 399
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:927 → 947
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl40432
      Location:50 → 207
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
      pfam00096
      Location:925 → 947
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:939 → 963
      zf-H2C2_2; Zinc-finger double domain

    2. XM_039101971.2 → XP_038957899.1  histone-lysine N-methyltransferase MECOM isoform X2

      UniProtKB/TrEMBL
      A0A8I6ASQ3, A0A8I6GM83
      Related
      ENSRNOP00000095014.1
      Conserved Domains (6) summary
      PHA00733
      Location:849 → 968
      PHA00733; hypothetical protein
      COG5189
      Location:347 → 399
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:918 → 938
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl40432
      Location:50 → 207
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
      pfam00096
      Location:916 → 938
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:930 → 954
      zf-H2C2_2; Zinc-finger double domain

    3. XM_063281551.1 → XP_063137621.1  histone-lysine N-methyltransferase MECOM isoform X7

      UniProtKB/TrEMBL
      A0A8I6AF72

    4. XM_039101975.2 → XP_038957903.1  histone-lysine N-methyltransferase MECOM isoform X11

      UniProtKB/TrEMBL
      A0A8I6AT27
      Related
      ENSRNOP00000095216.1
      Conserved Domains (6) summary
      COG5048
      Location:292 → 644
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:603 → 623
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl40432
      Location:50 → 207
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
      pfam00096
      Location:601 → 623
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:615 → 639
      zf-H2C2_2; Zinc-finger double domain
      cd20908
      Location:268 → 314
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    5. XM_063281555.1 → XP_063137625.1  histone-lysine N-methyltransferase MECOM isoform X15

      UniProtKB/TrEMBL
      A0A8I6AT27

    6. XM_063281554.1 → XP_063137624.1  histone-lysine N-methyltransferase MECOM isoform X13

      UniProtKB/TrEMBL
      A0A8I6AT27

    7. XM_039101970.2 → XP_038957898.1  histone-lysine N-methyltransferase MECOM isoform X1

      UniProtKB/TrEMBL
      A0A8I6GM83
      Related
      ENSRNOP00000097813.1
      Conserved Domains (6) summary
      PHA00733
      Location:880 → 976
      PHA00733; hypothetical protein
      COG5189
      Location:305 → 398
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:926 → 946
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl40432
      Location:50 → 207
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
      pfam00096
      Location:924 → 946
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:938 → 962
      zf-H2C2_2; Zinc-finger double domain

    8. XM_063281550.1 → XP_063137620.1  histone-lysine N-methyltransferase MECOM isoform X6

      UniProtKB/TrEMBL
      A0A8I6AF72

    9. XM_039101972.2 → XP_038957900.1  histone-lysine N-methyltransferase MECOM isoform X3

      UniProtKB/TrEMBL
      A0A8I6GM83
      Conserved Domains (6) summary
      PHA00733
      Location:848 → 967
      PHA00733; hypothetical protein
      COG5189
      Location:305 → 398
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:917 → 937
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl40432
      Location:50 → 207
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
      pfam00096
      Location:915 → 937
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:929 → 953
      zf-H2C2_2; Zinc-finger double domain

    10. XM_063281552.1 → XP_063137622.1  histone-lysine N-methyltransferase MECOM isoform X8

      UniProtKB/TrEMBL
      A0A8I6AF72

    11. XM_063281553.1 → XP_063137623.1  histone-lysine N-methyltransferase MECOM isoform X12

      UniProtKB/TrEMBL
      A0A8I6AT27

    12. XM_039101976.2 → XP_038957904.1  histone-lysine N-methyltransferase MECOM isoform X14

      UniProtKB/TrEMBL
      A0A8I6AT27

    13. XM_063281556.1 → XP_063137626.1  histone-lysine N-methyltransferase MECOM isoform X16

      UniProtKB/TrEMBL
      A0A8I6AT27

    14. XM_039101973.2 → XP_038957901.1  histone-lysine N-methyltransferase MECOM isoform X4

      UniProtKB/TrEMBL
      A0A8I6GM83
      Conserved Domains (6) summary
      PHA00733
      Location:870 → 966
      PHA00733; hypothetical protein
      COG5189
      Location:336 → 388
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:916 → 936
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl40432
      Location:39 → 196
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
      pfam00096
      Location:914 → 936
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:928 → 952
      zf-H2C2_2; Zinc-finger double domain

    15. XM_006232250.5 → XP_006232312.1  histone-lysine N-methyltransferase MECOM isoform X10

      UniProtKB/TrEMBL
      A0A8I6GM83
      Related
      ENSRNOP00000091427.1
      Conserved Domains (4) summary
      sd00017
      Location:736 → 756
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:734 → 756
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:748 → 772
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:164 → 245
      zf-C2H2_8; C2H2-type zinc ribbon

    16. XM_006232249.5 → XP_006232311.1  histone-lysine N-methyltransferase MECOM isoform X9

      UniProtKB/TrEMBL
      A0A8I6GM83
      Conserved Domains (5) summary
      smart00317
      Location:7 → 68
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      sd00017
      Location:800 → 820
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:798 → 820
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:812 → 836
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:228 → 309
      zf-C2H2_8; C2H2-type zinc ribbon

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106423.1: Suppressed sequence

      Description
      NM_001106423.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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