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    LINC00467 long intergenic non-protein coding RNA 467 [ Homo sapiens (human) ]

    Gene ID: 84791, updated on 19-Feb-2024

    Summary

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    Official Symbol
    LINC00467provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 467provided by HGNC
    Primary source
    HGNC:HGNC:28227
    See related
    Ensembl:ENSG00000153363 MIM:620079; AllianceGenome:HGNC:28227
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ASAP; C1orf97
    Expression
    Biased expression in testis (RPKM 117.7) and thyroid (RPKM 6.1) See more
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    Genomic context

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    Location:
    1q32.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (211382755..211432535)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (210628363..210678151)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (211556097..211605877)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2483 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1784 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2484 Neighboring gene TNF receptor associated factor 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1785 Neighboring gene uncharacterized LOC124904504 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:211550792-211551568 Neighboring gene uncharacterized LOC107985259 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2485 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:211571607-211572350 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:211573836-211574577 Neighboring gene sorting nexin 25 pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:211612887-211613110 Neighboring gene actin related protein 2/3 complex subunit 3 pseudogene 2 Neighboring gene RD3 regulator of GUCY2D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LINC00467 facilitates the proliferation, migration and invasion of glioma via promoting the expression of inositol hexakisphosphate kinase 2 by binding to miR-339-3p. Zhang Y, et al. Bioengineered, 2022 Feb. PMID 35156508, Free PMC Article
    2. LINC00467 Is Upregulated by DNA Copy Number Amplification and Hypomethylation and Shows ceRNA Potential in Lung Adenocarcinoma. Wang W, et al. Front Endocrinol (Lausanne), 2021. PMID 35095769, Free PMC Article
    3. Micropeptide ASAP encoded by LINC00467 promotes colorectal cancer progression by directly modulating ATP synthase activity. Ge Q, et al. J Clin Invest, 2021 Nov 15. PMID 34591791, Free PMC Article
    4. [Expression of long non-coding RNA linc00467 in childhood acute myeloid leukemia and its role in drug resistance]. Rao CB, et al. Zhongguo Dang Dai Er Ke Za Zhi, 2020 Jul. PMID 32669170, Free PMC Article
    5. The Rs12569232 SNP Association with Vogt-Koyanagi-Harada Disease and Behcet's Disease is Probably Mediated by Regulation of Linc00467 Expression. Wang Q, et al. Ocul Immunol Inflamm, 2021 Nov 17. PMID 32400232

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LINC00467 mediates the 5-fluorouracil resistance in breast cancer cells.
      Title: LINC00467 mediates the 5-fluorouracil resistance in breast cancer cells.
    2. LINC00467 enhanced the proliferative, migratory and invasive ability of breast cancer cells by targeting miR-18a/b-5p/MAPK4 axis.
      Title: LINC00467 enhanced the proliferative, migratory and invasive ability of breast cancer cells by targeting miR-18a/b-5p/MAPK4 axis.
    3. Silencing of LINC00467 inhibits cell proliferation in testicular germ cell tumors cells.
      Title: Silencing of LINC00467 inhibits cell proliferation in testicular germ cell tumors cells.
    4. LINC00467 facilitates the proliferation, migration and invasion of glioma via promoting the expression of inositol hexakisphosphate kinase 2 by binding to miR-339-3p.
      Title: LINC00467 facilitates the proliferation, migration and invasion of glioma via promoting the expression of inositol hexakisphosphate kinase 2 by binding to miR-339-3p.
    5. Downregulated Reprimo by LINC00467 participates in the growth and metastasis of gastric cancer.
      Title: Downregulated Reprimo by LINC00467 participates in the growth and metastasis of gastric cancer.
    6. LINC00467 Is Upregulated by DNA Copy Number Amplification and Hypomethylation and Shows ceRNA Potential in Lung Adenocarcinoma.
      Title: LINC00467 Is Upregulated by DNA Copy Number Amplification and Hypomethylation and Shows ceRNA Potential in Lung Adenocarcinoma.
    7. Overexpressed LINC00467 promotes the viability and proliferation yet inhibits apoptosis of gastric cancer cells via raising ITGB3 level.
      Title: Overexpressed LINC00467 promotes the viability and proliferation yet inhibits apoptosis of gastric cancer cells via raising ITGB3 level.
    8. Knockdown of LINC00467 contributed to Axitinib sensitivity in hepatocellular carcinoma through miR-509-3p/PDGFRA axis.
      Title: Knockdown of LINC00467 contributed to Axitinib sensitivity in hepatocellular carcinoma through miR-509-3p/PDGFRA axis.
    9. The Rs12569232 SNP Association with Vogt-Koyanagi-Harada Disease and Behcet's Disease is Probably Mediated by Regulation of Linc00467 Expression.
      Title: The Rs12569232 SNP Association with Vogt-Koyanagi-Harada Disease and Behcet's Disease is Probably Mediated by Regulation of Linc00467 Expression.
    10. Linc00467 promotion of gastric cancer development by directly regulating miR-7-5p expression and downstream epidermal growth factor receptor.
      Title: Linc00467 promotion of gastric cancer development by directly regulating miR-7-5p expression and downstream epidermal growth factor receptor.
    Submit: New GeneRIF Correction See all GeneRIFs (28)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • ATP synthase-associated peptide

    Clone Names

    • FLJ27347, FLJ27348, MGC14801

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_026761.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK130858, BC005997, BP197632
      Related
      ENST00000656082.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      211382755..211432535
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      210628363..210678151
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_032705.3: Suppressed sequence

      Description
      NM_032705.3: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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