KIF13B kinesin family member 13B [Homo sapiens (human)] - Gene

Summary

Official Symbol: KIF13Bprovided by HGNC
Official Full Name: kinesin family member 13Bprovided by HGNC
Primary source: HGNC:HGNC:14405
See related: Ensembl:ENSG00000197892 MIM:607350; AllianceGenome:HGNC:14405
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GAKIN
Summary: Enables 14-3-3 protein binding activity and protein kinase binding activity. Involved in regulation of axonogenesis. Located in axon and cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in kidney (RPKM 15.2), colon (RPKM 14.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8p12

Exon count:: 42

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (29067278..29263388, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (29345440..29541595, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (28924795..29120587, complement)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KIF13B mediates VEGFR2 recycling to modulate vascular permeability.
Title: KIF13B mediates VEGFR2 recycling to modulate vascular permeability.
Transient accumulation and bidirectional movement of KIF13B in primary cilia.
Title: Transient accumulation and bidirectional movement of KIF13B in primary cilia.
Changes in Protein Glycosylation as a Result of Aptamer Interactions with Cancer Cells.
Title: Changes in Protein Glycosylation as a Result of Aptamer Interactions with Cancer Cells.
Study provides evidence that KIF13B and NPHP4 are both required for establishment of a specialized caveolin-1 membrane microdomain at the ciliary transition zone, which is essential for Shh-induced accumulation of SMO in the primary cilium as well as for activation of GLI-mediated target gene expression.
Title: KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling.
Findings show that the high-affinity binding of KIF13B to DLG guanylate kinase (GK) domain does not require phosphorylation of KIF13B and that DLG binds to an unphosphorylated and autonomously folded domain within its stalk region (MAGUK binding stalk [MBS] domain) with high specificity and affinity.
Title: An Atypical MAGUK GK Target Recognition Mode Revealed by the Interaction between DLG and KIF13B.
lnc-KIF13B-1, a long non-coding RNA (rs6434720) is associated with corticobasal degeneration.
Title: Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy.
KIF13B is an essential molecular motor required for the trafficking of VEGFR2 from the Golgi, and its delivery to the endothelial cell surface mediates angiogenesis.
Title: KIF13B regulates angiogenesis through Golgi to plasma membrane trafficking of VEGFR2.
Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1.
Title: Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
These results reveal that GAKIN/KIF13B is a key intermediate linking Par1b to the regulation of axon formation.
Title: Par1b/MARK2 phosphorylates kinesin-like motor protein GAKIN/KIF13B to regulate axon formation.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association of lipid-lowering response to statins in combined study populations. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH92687 (e-PCR)
- UniSTS:91905

RH77858 (e-PCR)
- UniSTS:22276

G59135 (e-PCR)
- UniSTS:136456

RH45199 (e-PCR)
- UniSTS:24584

SHGC-3342 (e-PCR)
- UniSTS:78369

WI-16549 (e-PCR)
- UniSTS:59687

A009U09 (e-PCR)
- UniSTS:62762

RH102477 (e-PCR)
- UniSTS:96811

G66850 (e-PCR)
- UniSTS:166715

SHGC-52529 (e-PCR)
- UniSTS:2623

A008Q36 (e-PCR)
- UniSTS:81225

SHGC-36290 (e-PCR)
- UniSTS:62818

RH123152 (e-PCR)
- UniSTS:135533

WI-14186 (e-PCR)
- UniSTS:6261

SHGC-132937 (e-PCR)
- UniSTS:173981

WI-21790 (e-PCR)
- UniSTS:22430

G32834 (e-PCR)
- UniSTS:117413

G59618 (e-PCR)
- UniSTS:136921

SHGC-5779 (e-PCR)
- UniSTS:23018

SHGC-5760 (e-PCR)
- UniSTS:38399

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 14-3-3 protein binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell activation	NAS Non-traceable Author Statement more info	PubMed
involved_in cytoskeleton-dependent intracellular transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based movement	TAS Traceable Author Statement more info	PubMed
involved_in protein targeting	TAS Traceable Author Statement more info	PubMed
involved_in regulation of axonogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kinesin-like protein KIF13B

Names: guanylate kinase associated kinesin; kinesin 13B; kinesin-like protein GAKIN

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_015254.4 → NP_056069.2 kinesin-like protein KIF13B

See identical proteins and their annotated locations for NP_056069.2

Status: VALIDATED

Source sequence(s)

AB014539, AC108449, AI760125, DA068190, DA437040

Consensus CDS

CCDS55217.1

UniProtKB/Swiss-Prot

B4DGY5, B5MC45, F8VPJ2, O75134, Q9BYJ6, Q9NQT8

Related

ENSP00000427900.1, ENST00000524189.6

Conserved Domains (10) summary

smart00129
Location:6 → 360

KISc; Kinesin motor, catalytic domain. ATPase

cd00060
Location:447 → 544

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01365
Location:4 → 360

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam01302
Location:1704 → 1767

CAP_GLY; CAP-Gly domain

pfam03957
Location:1539 → 1643

Jun; Jun-like transcription factor

pfam12423
Location:756 → 802

KIF1B; Kinesin protein 1B

pfam12473
Location:1221 → 1279

DUF3694; Kinesin protein

pfam16183
Location:357 → 469

Kinesin_assoc; Kinesin-associated

cl23720
Location:610 → 710

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

cl23748
Location:1099 → 1143

DUF3585; Protein of unknown function (DUF3585)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000008.11 Reference GRCh38.p14 Primary Assembly

Range

29067278..29263388 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011544459.4 → XP_011542761.1 kinesin-like protein KIF13B isoform X4

See identical proteins and their annotated locations for XP_011542761.1

Conserved Domains (11) summary

smart00129
Location:9 → 296

KISc; Kinesin motor, catalytic domain. ATPase

COG1716
Location:395 → 508

FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]

cd00060
Location:383 → 480

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01365
Location:3 → 296

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam01302
Location:1661 → 1724

CAP_GLY; CAP-Gly domain

pfam03957
Location:1496 → 1600

Jun; Jun-like transcription factor

pfam12423
Location:692 → 738

KIF1B; Kinesin protein 1B

pfam12473
Location:1157 → 1215

DUF3694; Kinesin protein

pfam16183
Location:293 → 405

Kinesin_assoc; Kinesin-associated

cl23720
Location:546 → 646

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

cl23748
Location:1035 → 1079

DUF3585; Protein of unknown function (DUF3585)
XM_005273458.2 → XP_005273515.1 kinesin-like protein KIF13B isoform X3

Conserved Domains (11) summary

smart00129
Location:6 → 360

KISc; Kinesin motor, catalytic domain. ATPase

COG1716
Location:459 → 572

FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]

cd00060
Location:447 → 544

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01365
Location:4 → 360

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam01302
Location:1683 → 1746

CAP_GLY; CAP-Gly domain

pfam03957
Location:1518 → 1622

Jun; Jun-like transcription factor

pfam12423
Location:756 → 802

KIF1B; Kinesin protein 1B

pfam12473
Location:1221 → 1279

DUF3694; Kinesin protein

pfam16183
Location:357 → 469

Kinesin_assoc; Kinesin-associated

cl23720
Location:610 → 710

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

cl23748
Location:1099 → 1143

DUF3585; Protein of unknown function (DUF3585)
XM_011544458.2 → XP_011542760.1 kinesin-like protein KIF13B isoform X2

Conserved Domains (10) summary

smart00129
Location:6 → 360

KISc; Kinesin motor, catalytic domain. ATPase

cd00060
Location:447 → 544

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01365
Location:4 → 360

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam01302
Location:1704 → 1767

CAP_GLY; CAP-Gly domain

pfam03957
Location:1539 → 1643

Jun; Jun-like transcription factor

pfam12423
Location:756 → 802

KIF1B; Kinesin protein 1B

pfam12473
Location:1221 → 1279

DUF3694; Kinesin protein

pfam16183
Location:357 → 469

Kinesin_assoc; Kinesin-associated

cl23720
Location:610 → 710

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

cl23748
Location:1099 → 1143

DUF3585; Protein of unknown function (DUF3585)
XM_011544457.2 → XP_011542759.1 kinesin-like protein KIF13B isoform X1

Conserved Domains (10) summary

smart00129
Location:6 → 360

KISc; Kinesin motor, catalytic domain. ATPase

cd00060
Location:447 → 544

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01365
Location:4 → 360

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam01302
Location:1725 → 1788

CAP_GLY; CAP-Gly domain

pfam03957
Location:1560 → 1664

Jun; Jun-like transcription factor

pfam12423
Location:756 → 802

KIF1B; Kinesin protein 1B

pfam12473
Location:1221 → 1279

DUF3694; Kinesin protein

pfam16183
Location:357 → 469

Kinesin_assoc; Kinesin-associated

cl23720
Location:610 → 710

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

cl23748
Location:1099 → 1143

DUF3585; Protein of unknown function (DUF3585)
XM_047421619.1 → XP_047277575.1 kinesin-like protein KIF13B isoform X4
XM_011544460.4 → XP_011542762.1 kinesin-like protein KIF13B isoform X4

See identical proteins and their annotated locations for XP_011542762.1

Conserved Domains (11) summary

smart00129
Location:9 → 296

KISc; Kinesin motor, catalytic domain. ATPase

COG1716
Location:395 → 508

FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]

cd00060
Location:383 → 480

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01365
Location:3 → 296

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam01302
Location:1661 → 1724

CAP_GLY; CAP-Gly domain

pfam03957
Location:1496 → 1600

Jun; Jun-like transcription factor

pfam12423
Location:692 → 738

KIF1B; Kinesin protein 1B

pfam12473
Location:1157 → 1215

DUF3694; Kinesin protein

pfam16183
Location:293 → 405

Kinesin_assoc; Kinesin-associated

cl23720
Location:546 → 646

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

cl23748
Location:1035 → 1079

DUF3585; Protein of unknown function (DUF3585)
XM_017013257.2 → XP_016868746.1 kinesin-like protein KIF13B isoform X5