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    Islr2 immunoglobulin superfamily containing leucine-rich repeat 2 [ Mus musculus (house mouse) ]

    Gene ID: 320563, updated on 12-May-2024

    Summary

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    Official Symbol
    Islr2provided by MGI
    Official Full Name
    immunoglobulin superfamily containing leucine-rich repeat 2provided by MGI
    Primary source
    MGI:MGI:2444277
    See related
    Ensembl:ENSMUSG00000051243 AllianceGenome:MGI:2444277
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Linx; Mbu-3; mKIAA1465; B930052A04Rik
    Summary
    Involved in positive regulation of axon extension. Located in cell surface. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Orthologous to human ISLR2 (immunoglobulin superfamily containing leucine rich repeat 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in whole brain E14.5 (RPKM 62.5), CNS E14 (RPKM 61.4) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Islr2 in Genome Data Viewer
    Location:
    9 B; 9 31.63 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (58103580..58113563, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (58196297..58204319, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene immunoglobulin superfamily containing leucine-rich repeat Neighboring gene predicted gene, 39344 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10552 Neighboring gene microRNA 6385 Neighboring gene promyelocytic leukemia Neighboring gene STARR-positive B cell enhancer ABC_E2891 Neighboring gene stomatin-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of tissue-specific mbu-3 gene expression in the mouse central nervous system. Lee CJ, et al. BMB Rep, 2008 Dec 31. PMID 19123979
    2. The LRR and Ig domain-containing membrane protein SST273 is expressed on motoneurons. Gejima R, et al. Gene Expr Patterns, 2006 Mar. PMID 16378755
    3. Essential Role of Linx/Islr2 in the Development of the Forebrain Anterior Commissure. Abudureyimu S, et al. Sci Rep, 2018 May 8. PMID 29739947, Free PMC Article
    4. Linx mediates interaxonal interactions and formation of the internal capsule. Mandai K, et al. Neuron, 2014 Jul 2. PMID 24930700, Free PMC Article
    5. LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development. Mandai K, et al. Neuron, 2009 Sep 10. PMID 19755105, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data suggest a role for Linx in the regulation of complex forebrain connectivity, and future identification of its extracellular ligand(s) will help clarify this function.
      Title: Essential Role of Linx/Islr2 in the Development of the Forebrain Anterior Commissure.
    2. we identify a novel role for the LRR receptor Islr2 in ensuring proper axon navigation at the optic chiasm of both zebrafish and mouse.
      Title: The LRR receptor Islr2 is required for retinal axon routing at the vertebrate optic chiasm.
    3. Linx guides the extension of thalamocortical axons in the ventral forebrain.
      Title: Linx mediates interaxonal interactions and formation of the internal capsule.
    4. These findings show that LIGs such as Linx physically interact with Trk receptor tyrosine kinases and modulate their activities to control axonal extension, guidance and branching
      Title: LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development.
    5. During the embryonic stages, mbu-3 was localized to the central nervous system in the brain and spinal cord. In the early post-natal stages, the gene was evenly expressed in the brain.
      Title: Characterization of tissue-specific mbu-3 gene expression in the mouse central nervous system.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of axon extension IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of axon extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    immunoglobulin superfamily containing leucine-rich repeat protein 2
    Names
    leucine-rich repeat domain and immunoglobulin domain containing axon extension protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161535.1 → NP_001155007.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      BC096531
      Consensus CDS
      CCDS52812.1
      UniProtKB/TrEMBL
      E9Q9N7
      Related
      ENSMUSP00000130879.2, ENSMUST00000163200.3
      Conserved Domains (5) summary
      smart00082
      Location:225 → 273
      LRRCT; Leucine rich repeat C-terminal domain
      sd00033
      Location:80 → 96
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:144 → 183
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:164 → 227
      LRR_8; Leucine rich repeat
      pfam13895
      Location:288 → 417
      Ig_2; Immunoglobulin domain

    2. NM_001161536.1 → NP_001155008.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform b precursor

      See identical proteins and their annotated locations for NP_001155008.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 2-8 encode the same isoform.
      Source sequence(s)
      BC096531, CA325040, CA328406
      Consensus CDS
      CCDS23238.1
      UniProtKB/Swiss-Prot
      C8XPY9, Q5RKR3, Q6ZPQ3
      Related
      ENSMUSP00000130322.2, ENSMUST00000163897.8
      Conserved Domains (6) summary
      TIGR00864
      Location:154 → 228
      PCC; polycystin cation channel protein
      sd00033
      Location:36 → 52
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:99 → 159
      LRR_8; Leucine rich repeat
      pfam13927
      Location:232 → 360
      Ig_3; Immunoglobulin domain
      cd00096
      Location:256 → 263
      Ig; Ig strand B [structural motif]
      cl11960
      Location:351 → 373
      Ig; Immunoglobulin domain

    3. NM_001161537.1 → NP_001155009.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform b precursor

      See identical proteins and their annotated locations for NP_001155009.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 2-8 encode the same isoform.
      Source sequence(s)
      BC096531, CB526596
      Consensus CDS
      CCDS23238.1
      UniProtKB/Swiss-Prot
      C8XPY9, Q5RKR3, Q6ZPQ3
      Conserved Domains (6) summary
      TIGR00864
      Location:154 → 228
      PCC; polycystin cation channel protein
      sd00033
      Location:36 → 52
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:99 → 159
      LRR_8; Leucine rich repeat
      pfam13927
      Location:232 → 360
      Ig_3; Immunoglobulin domain
      cd00096
      Location:256 → 263
      Ig; Ig strand B [structural motif]
      cl11960
      Location:351 → 373
      Ig; Immunoglobulin domain

    4. NM_001161538.1 → NP_001155010.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform b precursor

      See identical proteins and their annotated locations for NP_001155010.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 2-8 encode the same isoform.
      Source sequence(s)
      BC096531, CA750352
      Consensus CDS
      CCDS23238.1
      UniProtKB/Swiss-Prot
      C8XPY9, Q5RKR3, Q6ZPQ3
      Related
      ENSMUSP00000127228.2, ENSMUST00000170421.8
      Conserved Domains (6) summary
      TIGR00864
      Location:154 → 228
      PCC; polycystin cation channel protein
      sd00033
      Location:36 → 52
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:99 → 159
      LRR_8; Leucine rich repeat
      pfam13927
      Location:232 → 360
      Ig_3; Immunoglobulin domain
      cd00096
      Location:256 → 263
      Ig; Ig strand B [structural motif]
      cl11960
      Location:351 → 373
      Ig; Immunoglobulin domain

    5. NM_001161539.1 → NP_001155011.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform b precursor

      See identical proteins and their annotated locations for NP_001155011.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 2-8 encode the same isoform.
      Source sequence(s)
      BC096531, CD350184
      Consensus CDS
      CCDS23238.1
      UniProtKB/Swiss-Prot
      C8XPY9, Q5RKR3, Q6ZPQ3
      Conserved Domains (6) summary
      TIGR00864
      Location:154 → 228
      PCC; polycystin cation channel protein
      sd00033
      Location:36 → 52
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:99 → 159
      LRR_8; Leucine rich repeat
      pfam13927
      Location:232 → 360
      Ig_3; Immunoglobulin domain
      cd00096
      Location:256 → 263
      Ig; Ig strand B [structural motif]
      cl11960
      Location:351 → 373
      Ig; Immunoglobulin domain

    6. NM_001161540.1 → NP_001155012.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform b precursor

      See identical proteins and their annotated locations for NP_001155012.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 2-8 encode the same isoform.
      Source sequence(s)
      BC096531, BQ443868, BY111208
      Consensus CDS
      CCDS23238.1
      UniProtKB/Swiss-Prot
      C8XPY9, Q5RKR3, Q6ZPQ3
      Related
      ENSMUSP00000129328.2, ENSMUST00000165276.2
      Conserved Domains (6) summary
      TIGR00864
      Location:154 → 228
      PCC; polycystin cation channel protein
      sd00033
      Location:36 → 52
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:99 → 159
      LRR_8; Leucine rich repeat
      pfam13927
      Location:232 → 360
      Ig_3; Immunoglobulin domain
      cd00096
      Location:256 → 263
      Ig; Ig strand B [structural motif]
      cl11960
      Location:351 → 373
      Ig; Immunoglobulin domain

    7. NM_001161541.1 → NP_001155013.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform b precursor

      See identical proteins and their annotated locations for NP_001155013.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 2-8 encode the same isoform.
      Source sequence(s)
      BB611833, BC096531
      Consensus CDS
      CCDS23238.1
      UniProtKB/Swiss-Prot
      C8XPY9, Q5RKR3, Q6ZPQ3
      Related
      ENSMUSP00000109781.3, ENSMUST00000114144.9
      Conserved Domains (6) summary
      TIGR00864
      Location:154 → 228
      PCC; polycystin cation channel protein
      sd00033
      Location:36 → 52
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:99 → 159
      LRR_8; Leucine rich repeat
      pfam13927
      Location:232 → 360
      Ig_3; Immunoglobulin domain
      cd00096
      Location:256 → 263
      Ig; Ig strand B [structural motif]
      cl11960
      Location:351 → 373
      Ig; Immunoglobulin domain

    8. NM_177193.5 → NP_796167.2  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform b precursor

      See identical proteins and their annotated locations for NP_796167.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 2-8 encode the same isoform.
      Source sequence(s)
      BC059068, BY079125, CA328406
      Consensus CDS
      CCDS23238.1
      UniProtKB/Swiss-Prot
      C8XPY9, Q5RKR3, Q6ZPQ3
      Related
      ENSMUSP00000149095.2, ENSMUST00000215950.2
      Conserved Domains (6) summary
      TIGR00864
      Location:154 → 228
      PCC; polycystin cation channel protein
      sd00033
      Location:36 → 52
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:99 → 159
      LRR_8; Leucine rich repeat
      pfam13927
      Location:232 → 360
      Ig_3; Immunoglobulin domain
      cd00096
      Location:256 → 263
      Ig; Ig strand B [structural motif]
      cl11960
      Location:351 → 373
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      58103580..58113563 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155062.1 → XP_036010955.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

      UniProtKB/Swiss-Prot
      C8XPY9, Q5RKR3, Q6ZPQ3
      Conserved Domains (6) summary
      TIGR00864
      Location:154 → 228
      PCC; polycystin cation channel protein
      sd00033
      Location:36 → 52
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:99 → 159
      LRR_8; Leucine rich repeat
      pfam13927
      Location:232 → 360
      Ig_3; Immunoglobulin domain
      cd00096
      Location:256 → 263
      Ig; Ig strand B [structural motif]
      cl11960
      Location:351 → 373
      Ig; Immunoglobulin domain

    2. XM_036155064.1 → XP_036010957.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

      UniProtKB/Swiss-Prot
      C8XPY9, Q5RKR3, Q6ZPQ3
      Conserved Domains (6) summary
      TIGR00864
      Location:154 → 228
      PCC; polycystin cation channel protein
      sd00033
      Location:36 → 52
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:99 → 159
      LRR_8; Leucine rich repeat
      pfam13927
      Location:232 → 360
      Ig_3; Immunoglobulin domain
      cd00096
      Location:256 → 263
      Ig; Ig strand B [structural motif]
      cl11960
      Location:351 → 373
      Ig; Immunoglobulin domain

    3. XM_036155061.1 → XP_036010954.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

      UniProtKB/Swiss-Prot
      C8XPY9, Q5RKR3, Q6ZPQ3
      Conserved Domains (6) summary
      TIGR00864
      Location:154 → 228
      PCC; polycystin cation channel protein
      sd00033
      Location:36 → 52
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:99 → 159
      LRR_8; Leucine rich repeat
      pfam13927
      Location:232 → 360
      Ig_3; Immunoglobulin domain
      cd00096
      Location:256 → 263
      Ig; Ig strand B [structural motif]
      cl11960
      Location:351 → 373
      Ig; Immunoglobulin domain

    4. XM_030244418.2 → XP_030100278.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

      UniProtKB/Swiss-Prot
      C8XPY9, Q5RKR3, Q6ZPQ3
      Conserved Domains (6) summary
      TIGR00864
      Location:154 → 228
      PCC; polycystin cation channel protein
      sd00033
      Location:36 → 52
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:99 → 159
      LRR_8; Leucine rich repeat
      pfam13927
      Location:232 → 360
      Ig_3; Immunoglobulin domain
      cd00096
      Location:256 → 263
      Ig; Ig strand B [structural motif]
      cl11960
      Location:351 → 373
      Ig; Immunoglobulin domain

    5. XM_006511230.3 → XP_006511293.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006511293.1

      UniProtKB/Swiss-Prot
      C8XPY9, Q5RKR3, Q6ZPQ3
      Conserved Domains (6) summary
      TIGR00864
      Location:154 → 228
      PCC; polycystin cation channel protein
      sd00033
      Location:36 → 52
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:99 → 159
      LRR_8; Leucine rich repeat
      pfam13927
      Location:232 → 360
      Ig_3; Immunoglobulin domain
      cd00096
      Location:256 → 263
      Ig; Ig strand B [structural motif]
      cl11960
      Location:351 → 373
      Ig; Immunoglobulin domain

    6. XM_036155065.1 → XP_036010958.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

      UniProtKB/Swiss-Prot
      C8XPY9, Q5RKR3, Q6ZPQ3
      Conserved Domains (6) summary
      TIGR00864
      Location:154 → 228
      PCC; polycystin cation channel protein
      sd00033
      Location:36 → 52
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:99 → 159
      LRR_8; Leucine rich repeat
      pfam13927
      Location:232 → 360
      Ig_3; Immunoglobulin domain
      cd00096
      Location:256 → 263
      Ig; Ig strand B [structural motif]
      cl11960
      Location:351 → 373
      Ig; Immunoglobulin domain

    7. XM_006511229.4 → XP_006511292.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006511292.1

      UniProtKB/Swiss-Prot
      C8XPY9, Q5RKR3, Q6ZPQ3
      Conserved Domains (6) summary
      TIGR00864
      Location:154 → 228
      PCC; polycystin cation channel protein
      sd00033
      Location:36 → 52
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:99 → 159
      LRR_8; Leucine rich repeat
      pfam13927
      Location:232 → 360
      Ig_3; Immunoglobulin domain
      cd00096
      Location:256 → 263
      Ig; Ig strand B [structural motif]
      cl11960
      Location:351 → 373
      Ig; Immunoglobulin domain

    8. XM_006511232.4 → XP_006511295.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006511295.1

      UniProtKB/Swiss-Prot
      C8XPY9, Q5RKR3, Q6ZPQ3
      Conserved Domains (6) summary
      TIGR00864
      Location:154 → 228
      PCC; polycystin cation channel protein
      sd00033
      Location:36 → 52
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:99 → 159
      LRR_8; Leucine rich repeat
      pfam13927
      Location:232 → 360
      Ig_3; Immunoglobulin domain
      cd00096
      Location:256 → 263
      Ig; Ig strand B [structural motif]
      cl11960
      Location:351 → 373
      Ig; Immunoglobulin domain

    9. XM_030244417.1 → XP_030100277.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

      UniProtKB/Swiss-Prot
      C8XPY9, Q5RKR3, Q6ZPQ3
      Conserved Domains (6) summary
      TIGR00864
      Location:154 → 228
      PCC; polycystin cation channel protein
      sd00033
      Location:36 → 52
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:99 → 159
      LRR_8; Leucine rich repeat
      pfam13927
      Location:232 → 360
      Ig_3; Immunoglobulin domain
      cd00096
      Location:256 → 263
      Ig; Ig strand B [structural motif]
      cl11960
      Location:351 → 373
      Ig; Immunoglobulin domain

    10. XM_006511231.5 → XP_006511294.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006511294.1

      UniProtKB/Swiss-Prot
      C8XPY9, Q5RKR3, Q6ZPQ3
      Conserved Domains (6) summary
      TIGR00864
      Location:154 → 228
      PCC; polycystin cation channel protein
      sd00033
      Location:36 → 52
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:99 → 159
      LRR_8; Leucine rich repeat
      pfam13927
      Location:232 → 360
      Ig_3; Immunoglobulin domain
      cd00096
      Location:256 → 263
      Ig; Ig strand B [structural motif]
      cl11960
      Location:351 → 373
      Ig; Immunoglobulin domain

    11. XM_006511234.5 → XP_006511297.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006511297.1

      UniProtKB/Swiss-Prot
      C8XPY9, Q5RKR3, Q6ZPQ3
      Conserved Domains (6) summary
      TIGR00864
      Location:154 → 228
      PCC; polycystin cation channel protein
      sd00033
      Location:36 → 52
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:99 → 159
      LRR_8; Leucine rich repeat
      pfam13927
      Location:232 → 360
      Ig_3; Immunoglobulin domain
      cd00096
      Location:256 → 263
      Ig; Ig strand B [structural motif]
      cl11960
      Location:351 → 373
      Ig; Immunoglobulin domain

    12. XM_030244419.2 → XP_030100279.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

      UniProtKB/Swiss-Prot
      C8XPY9, Q5RKR3, Q6ZPQ3
      Conserved Domains (6) summary
      TIGR00864
      Location:154 → 228
      PCC; polycystin cation channel protein
      sd00033
      Location:36 → 52
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:99 → 159
      LRR_8; Leucine rich repeat
      pfam13927
      Location:232 → 360
      Ig_3; Immunoglobulin domain
      cd00096
      Location:256 → 263
      Ig; Ig strand B [structural motif]
      cl11960
      Location:351 → 373
      Ig; Immunoglobulin domain

    13. XM_036155063.1 → XP_036010956.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

      UniProtKB/Swiss-Prot
      C8XPY9, Q5RKR3, Q6ZPQ3
      Conserved Domains (6) summary
      TIGR00864
      Location:154 → 228
      PCC; polycystin cation channel protein
      sd00033
      Location:36 → 52
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:99 → 159
      LRR_8; Leucine rich repeat
      pfam13927
      Location:232 → 360
      Ig_3; Immunoglobulin domain
      cd00096
      Location:256 → 263
      Ig; Ig strand B [structural motif]
      cl11960
      Location:351 → 373
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5RKR3.1 GenPept UniProtKB/Swiss-Prot:Q5RKR3

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