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    Rrn3 RRN3 homolog, RNA polymerase I transcription factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304714, updated on 11-Apr-2024

    Summary

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    Symbol
    Rrn3provided by RGD
    Full Name
    RRN3 homolog, RNA polymerase I transcription factorprovided by RGD
    Primary source
    RGD:1305001
    See related
    Ensembl:ENSRNOG00000003326 AllianceGenome:RGD:1305001
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305001
    Summary
    Predicted to enable RNA polymerase I core binding activity; RNA polymerase I core promoter sequence-specific DNA binding activity; and RNA polymerase I general transcription initiation factor activity. Involved in positive regulation of neuron projection development. Predicted to be located in nucleolus. Predicted to be active in nucleus. Orthologous to several human genes including RRN3 (RRN3 homolog, RNA polymerase I transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 174.4), Muscle (RPKM 164.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rrn3 in Genome Data Viewer
    Location:
    10q11
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (2637016..2672338, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (2129949..2165381, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (3170387..3214648)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene pyridoxal-dependent decarboxylase domain containing 1 Neighboring gene N-terminal asparagine amidase Neighboring gene uncharacterized LOC102552514 Neighboring gene serine and arginine rich splicing factor 3, pseudogene 11 Neighboring gene HAUS augmin-like complex, subunit 4, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mammalian Rrn3 is required for the formation of a transcription competent preinitiation complex containing RNA polymerase I. Cavanaugh AH, et al. Gene Expr, 2008. PMID 18590050, Free PMC Article
    2. Phytochemical-induced nucleolar stress results in the inhibition of breast cancer cell proliferation. Lewinska A, et al. Redox Biol, 2017 Aug. PMID 28334682, Free PMC Article
    3. RNA polymerase 1-driven transcription as a mediator of BDNF-induced neurite outgrowth. Gomes C, et al. J Biol Chem, 2011 Feb 11. PMID 21098478, Free PMC Article
    4. Function of the growth-regulated transcription initiation factor TIF-IA in initiation complex formation at the murine ribosomal gene promoter. Schnapp A, et al. Mol Cell Biol, 1993 Nov. PMID 8413268, Free PMC Article
    5. Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis. Yuan X, et al. Mol Cell, 2005 Jul 1. PMID 15989966

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data demonstrate that Rrn3 must be present when the committed template complex is forming for transcription to occur.
      Title: Mammalian Rrn3 is required for the formation of a transcription competent preinitiation complex containing RNA polymerase I.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase I core binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase I core promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase I general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase I general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA-templated transcription initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA polymerase I preinitiation complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cytoplasm organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within homeostasis of number of cells ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of intrinsic apoptotic signaling pathway by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within nucleolus organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ribosome biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription initiation at RNA polymerase I promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within transcription initiation at RNA polymerase I promoter ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription initiation at RNA polymerase I promoter ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA polymerase I-specific transcription initiation factor RRN3
    Names
    RNA polymerase I-specific transcription initiation factor RRN3-like
    RRN3 RNA polymerase I transcription factor homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135846.1 → NP_001129318.1  RNA polymerase I-specific transcription initiation factor RRN3

      See identical proteins and their annotated locations for NP_001129318.1

      Status: PROVISIONAL

      Source sequence(s)
      BC166485
      UniProtKB/TrEMBL
      B2GV13
      Conserved Domains (1) summary
      pfam05327
      Location:54 → 588
      RRN3; RNA polymerase I specific transcription initiation factor RRN3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      2637016..2672338 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008767458.4 → XP_008765680.1  RNA polymerase I-specific transcription initiation factor RRN3 isoform X1

      See identical proteins and their annotated locations for XP_008765680.1

      UniProtKB/TrEMBL
      A0A0G2K8U0
      Related
      ENSRNOP00000074735.2
      Conserved Domains (1) summary
      pfam05327
      Location:54 → 583
      RRN3; RNA polymerase I specific transcription initiation factor RRN3
    Nucleotide Protein Strain
    Heading Accession and Version

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