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    Vps37a VPS37A subunit of ESCRT-I [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290775, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Vps37aprovided by RGD
    Official Full Name
    VPS37A subunit of ESCRT-Iprovided by RGD
    Primary source
    RGD:1560016
    See related
    Ensembl:ENSRNOG00000012001 AllianceGenome:RGD:1560016
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in protein targeting to membrane; protein targeting to vacuole; and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to be located in centrosome; cytosol; and nucleoplasm. Predicted to be part of ESCRT I complex. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 53. Orthologous to human VPS37A (VPS37A subunit of ESCRT-I). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 113.1), Thymus (RPKM 107.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Vps37a in Genome Data Viewer
    Location:
    16q12.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (58434802..58478777, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (51736170..51775384, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (54860811..54899410, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene a disintegrin and metallopeptidase domain 25 Neighboring gene ADAM metallopeptidase domain 24 Neighboring gene myotubularin related protein 7 Neighboring gene CCR4-NOT transcription complex, subunit 7 Neighboring gene zinc finger DHHC-type palmitoyltransferase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Distinct functions of human MVB12A and MVB12B in the ESCRT-I dependent on their posttranslational modifications. Tsunematsu T, et al. Biochem Biophys Res Commun, 2010 Aug 20. PMID 20654576
    2. UBAP1 is a component of an endosome-specific ESCRT-I complex that is essential for MVB sorting. Stefani F, et al. Curr Biol, 2011 Jul 26. PMID 21757351
    3. Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding. Morita E, et al. Cell Host Microbe, 2007 Jul 12. PMID 18005716, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116266

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of ESCRT I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ESCRT I complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    vacuolar protein sorting-associated protein 37A
    Names
    VPS37A, ESCRT-I subunit
    vacuolar protein sorting 37 homolog A
    vacuolar protein sorting 37A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024867.1 → NP_001020038.1  vacuolar protein sorting-associated protein 37A

      See identical proteins and their annotated locations for NP_001020038.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098069
      UniProtKB/TrEMBL
      A6JPV3, F7FHB3, Q4V794
      Related
      ENSRNOP00000016321.5, ENSRNOT00000016321.6
      Conserved Domains (1) summary
      pfam07200
      Location:236 → 381
      Mod_r; Modifier of rudimentary (Mod(r)) protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      58434802..58478777 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275236.1 → XP_063131306.1  vacuolar protein sorting-associated protein 37A isoform X2

      UniProtKB/TrEMBL
      A0A8I6GCD4

    2. XM_063275235.1 → XP_063131305.1  vacuolar protein sorting-associated protein 37A isoform X1

      UniProtKB/TrEMBL
      A6JPV3, F7FHB3, Q4V794

    3. XM_008771289.4 → XP_008769511.1  vacuolar protein sorting-associated protein 37A isoform X2

      UniProtKB/TrEMBL
      A0A8I6GCD4
      Related
      ENSRNOP00000085018.1
      Conserved Domains (1) summary
      pfam07200
      Location:236 → 358
      Mod_r; Modifier of rudimentary (Mod(r)) protein

    4. XM_039094386.2 → XP_038950314.1  vacuolar protein sorting-associated protein 37A isoform X3

      UniProtKB/TrEMBL
      A6JPV5
      Conserved Domains (1) summary
      pfam07200
      Location:90 → 235
      Mod_r; Modifier of rudimentary (Mod(r)) protein

    RNA

    1. XR_596484.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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