Ccl7 C-C motif chemokine ligand 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ccl7provided by RGD
Official Full Name: C-C motif chemokine ligand 7provided by RGD
Primary source: RGD:1359152
See related: Ensembl:ENSRNOG00000000239 AllianceGenome:RGD:1359152
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable CCR1 chemokine receptor binding activity; CCR2 chemokine receptor binding activity; and chemokine activity. Involved in cellular response to ethanol and response to gamma radiation. Predicted to be active in extracellular space. Used to study glomerulonephritis. Biomarker of bronchiolitis obliterans; interstitial nephritis; nephrosis; and silicosis. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human CCL7 (C-C motif chemokine ligand 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Uterus (RPKM 42.4), Heart (RPKM 36.6) and 8 other tissues See more
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Genomic context

Location:: 10q26

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (67514095..67515945)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (67016446..67018296)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (69423083..69424933)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HDAC2 exacerbates rheumatoid arthritis progression via the IL-17-CCL7 signaling pathway.
Title: HDAC2 exacerbates rheumatoid arthritis progression via the IL-17-CCL7 signaling pathway.
This study demonstrated that that Ccl7 promoted astrocyte proliferation and thus contributed toward neuropathic pain.
Title: Neuronal-derived Ccl7 drives neuropathic pain by promoting astrocyte proliferation.
TFPI inhibited MCP-3 expression induced by TNF-alpha; this effect may be propagated through the NF-kappaB/IkappaB-alpha pathway.
Title: The effect of tissue factor pathway inhibitor on the expression of monocyte chemotactic protein-3 and IκB-α stimulated by tumour necrosis factor-α in cultured vascular smooth muscle cells.
Data show that among expressed chemokines and cytokines, only CCL2, CCL7 and interleukin (IL)-6 were expressed at higher levels following FcepsilonRI-CCR1 costimulation.
Title: Identification of genes and proteins specifically regulated by costimulation of mast cell Fcε Receptor I and chemokine receptor 1.
Results show a function of CCL2 and CCL7 in the developing brain and identify beta-chemokines as novel class of pro-differentiation factors for midbrain dopamine neurons.
Title: The beta-chemokines CCL2 and CCL7 are two novel differentiation factors for midbrain dopaminergic precursors and neurons.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables CCR chemokine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables CCR1 chemokine receptor binding	ISO Inferred from Sequence Orthology more info
enables CCR2 chemokine receptor binding	ISO Inferred from Sequence Orthology more info
enables chemokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine activity	ISO Inferred from Sequence Orthology more info
enables heparin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to ethanol	IDA Inferred from Direct Assay more info	PubMed
involved_in chemokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in eosinophil chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in eosinophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in response to gamma radiation	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: C-C motif chemokine 7

Names: MCP-3; chemokine (C-C motif) ligand 7; chemotactic protein-3; monocyte chemoattractant protein 3; monocyte chemotactic protein 3; small-inducible cytokine A7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007612.1 → NP_001007613.1 C-C motif chemokine 7 precursor

See identical proteins and their annotated locations for NP_001007613.1

Status: PROVISIONAL

Source sequence(s)

AF154245

UniProtKB/Swiss-Prot

Q9QXY8

UniProtKB/TrEMBL

A6HHD3

Related

ENSRNOP00000000256.2, ENSRNOT00000000256.5

Conserved Domains (1) summary

cd00272
Location:33 → 89

Chemokine_CC; Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. ...