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    Rasal1 RAS protein activator like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360814, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Rasal1provided by RGD
    Official Full Name
    RAS protein activator like 1provided by RGD
    Primary source
    RGD:1311820
    See related
    Ensembl:ENSRNOG00000001374 AllianceGenome:RGD:1311820
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase activator activity; metal ion binding activity; and phospholipid binding activity. Predicted to be involved in positive regulation of dendrite extension. Predicted to be located in cytosol. Predicted to colocalize with plasma membrane. Orthologous to human RASAL1 (RAS protein activator like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 63.8), Adrenal (RPKM 56.7) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    12q16
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (41541865..41574957, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (35881269..35913727, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (41416218..41449445, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene 2'-5' oligoadenylate synthetase 2 Neighboring gene deltex E3 ubiquitin ligase 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit A1, pseudogene 2 Neighboring gene cilia and flagella associated protein 73 Neighboring gene DEAD-box helicase 54

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MeCP2 controls the expression of RASAL1 in the hepatic fibrosis in rats. Tao H, et al. Toxicology, 2011 Dec 18. PMID 22056649
    2. Paridis Rhizoma Sapoinins attenuates liver fibrosis in rats by regulating the expression of RASAL1/ERK1/2 signal pathway. Hong Y, et al. J Ethnopharmacol, 2016 Nov 4. PMID 27396351
    3. CAPRI and RASAL impose different modes of information processing on Ras due to contrasting temporal filtering of Ca2+. Liu Q, et al. J Cell Biol, 2005 Jul 18. PMID 16009725, Free PMC Article
    4. SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation. Yoo JC, et al. J Dermatol Sci, 2013 Dec. PMID 23999003

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Paridis rhizoma sapoinins attenuate CCl4-induced liver fibrosis through the regulation of RASAL1/ERK1/2 signal pathway.
      Title: Paridis Rhizoma Sapoinins attenuates liver fibrosis in rats by regulating the expression of RASAL1/ERK1/2 signal pathway.
    2. hypermethylation of RASAL1 is associated with the perpetuation of fibroblast activation and fibrogenesis in the liver
      Title: MeCP2 controls the expression of RASAL1 in the hepatic fibrosis in rats.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of dendrite extension ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rasGAP-activating-like protein 1
    Names
    RAS protein activator like 1 (GAP1 like)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108335.1 → NP_001101805.1  rasGAP-activating-like protein 1

      See identical proteins and their annotated locations for NP_001101805.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473973
      UniProtKB/TrEMBL
      A6J1I2, D3ZHY9
      Related
      ENSRNOP00000001856.6, ENSRNOT00000001856.7
      Conserved Domains (6) summary
      cd05135
      Location:262 → 548
      RasGAP_RASAL; Ras-GTPase Activating Domain of RASAL1 and similar proteins
      smart00323
      Location:242 → 604
      RasGAP; GTPase-activator protein for Ras-like GTPases
      pfam00169
      Location:566 → 672
      PH; PH domain
      pfam00779
      Location:681 → 708
      BTK; BTK motif
      cl14603
      Location:6 → 126
      C2; C2 domain
      cl17171
      Location:552 → 689
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      41541865..41574957 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249395.5 → XP_006249457.1  rasGAP-activating-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006249457.1

      UniProtKB/TrEMBL
      A6J1I2, D3ZHY9
      Conserved Domains (6) summary
      cd05135
      Location:262 → 548
      RasGAP_RASAL; Ras-GTPase Activating Domain of RASAL1 and similar proteins
      smart00323
      Location:242 → 604
      RasGAP; GTPase-activator protein for Ras-like GTPases
      pfam00169
      Location:566 → 672
      PH; PH domain
      pfam00779
      Location:681 → 708
      BTK; BTK motif
      cl14603
      Location:6 → 126
      C2; C2 domain
      cl17171
      Location:552 → 689
      PH-like; Pleckstrin homology-like domain

    2. XM_017598399.3 → XP_017453888.1  rasGAP-activating-like protein 1 isoform X3

      Conserved Domains (6) summary
      cd05135
      Location:80 → 366
      RasGAP_RASAL; Ras-GTPase Activating Domain of RASAL1 and similar proteins
      smart00323
      Location:60 → 422
      RasGAP; GTPase-activator protein for Ras-like GTPases
      pfam00169
      Location:384 → 490
      PH; PH domain
      pfam00779
      Location:499 → 526
      BTK; BTK motif
      cl14603
      Location:33 → 72
      C2; C2 domain
      cl17171
      Location:370 → 507
      PH-like; Pleckstrin homology-like domain

    3. XM_039089599.2 → XP_038945527.1  rasGAP-activating-like protein 1 isoform X2

      Conserved Domains (3) summary
      pfam00779
      Location:323 → 350
      BTK; BTK motif
      cl02569
      Location:1 → 190
      RasGAP; Ras GTPase Activating Domain
      cl17171
      Location:194 → 331
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein Strain
    Heading Accession and Version

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