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    INTS10 integrator complex subunit 10 [ Homo sapiens (human) ]

    Gene ID: 55174, updated on 5-Mar-2024

    Summary

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    Official Symbol
    INTS10provided by HGNC
    Official Full Name
    integrator complex subunit 10provided by HGNC
    Primary source
    HGNC:HGNC:25548
    See related
    Ensembl:ENSG00000104613 MIM:611353; AllianceGenome:HGNC:25548
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    INT10; C8orf35
    Summary
    INTS10 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 19.2), prostate (RPKM 12.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    8p21.3
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (19817416..19852067)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (20082438..20117090)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (19674927..19709578)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene chondroitin sulfate N-acetylgalactosaminyltransferase 1 Neighboring gene uncharacterized LOC124901899 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:19536806-19537406 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27058 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:19589033-19590232 Neighboring gene uncharacterized LOC107986920 Neighboring gene MPRA-validated peak6932 silencer Neighboring gene MPRA-validated peak6933 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:19670041-19670619 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27059 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27060 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18969 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27061 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27062 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27063 Neighboring gene uncharacterized LOC124901901 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:19713825-19714324 Neighboring gene NANOG hESC enhancer GRCh37_chr8:19717703-19718429 Neighboring gene uncharacterized LOC105379309

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Effects of genetic polymorphisms in INTS10 and their interaction with environmental factors on progression from persistent HBV infection to hepatocellular carcinoma. Wu Y, et al. Mol Carcinog, 2021 Sep. PMID 34133796
    2. Genome-wide association study identifies 8p21.3 associated with persistent hepatitis B virus infection among Chinese. Li Y, et al. Nat Commun, 2016 May 31. PMID 27244555, Free PMC Article
    3. Somatic Mutation Patterns in Hemizygous Genomic Regions Unveil Purifying Selection during Tumor Evolution. Van den Eynden J, et al. PLoS Genet, 2016 Dec. PMID 28027311, Free PMC Article
    4. Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides. Kooner JS, et al. Nat Genet, 2008 Feb. PMID 18193046
    5. Structure of the catalytic core of the Integrator complex. Pfleiderer MM, et al. Mol Cell, 2021 Mar 18. PMID 33548203, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Effects of genetic polymorphisms in INTS10 and their interaction with environmental factors on progression from persistent HBV infection to hepatocellular carcinoma.
      Title: Effects of genetic polymorphisms in INTS10 and their interaction with environmental factors on progression from persistent HBV infection to hepatocellular carcinoma.
    2. INTS10-INTS13-INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module.
      Title: INTS10-INTS13-INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module.
    3. Genome-wide association study in Chinise population highlights a novel antiviral gene INTS10 at 8p21.3 in the clearance of HBV infection. INST10 suppresses HBV replication via IRF3 in liver cells.
      Title: Genome-wide association study identifies 8p21.3 associated with persistent hepatitis B virus infection among Chinese.
    4. Using a 7,781-sample pan-cancer dataset, we first confirmed this in POLR2A are known to confer elevated sensitivity to pharmacological suppression.hese include the POLR2A interacting protein INTS10 as well as genes involved in mRNA splicing, nonsense-mediated mRNA
      Title: Somatic Mutation Patterns in Hemizygous Genomic Regions Unveil Purifying Selection during Tumor Evolution.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides.
    EBI GWAS Catalog
    Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
    EBI GWAS Catalog
    Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10569

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription elongation by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in snRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in snRNA processing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of integrator complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    integrator complex subunit 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001353505.2 → NP_001340434.1  integrator complex subunit 10 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC107964

    2. NM_001353506.2 → NP_001340435.1  integrator complex subunit 10 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC107964

    3. NM_001353507.2 → NP_001340436.1  integrator complex subunit 10 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC107964

    4. NM_001353508.2 → NP_001340437.1  integrator complex subunit 10 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC107964

    5. NM_001353509.2 → NP_001340438.1  integrator complex subunit 10 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC107964

    6. NM_001353510.2 → NP_001340439.1  integrator complex subunit 10 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC107964

    7. NM_001353511.2 → NP_001340440.1  integrator complex subunit 10 isoform h

      Status: VALIDATED

      Source sequence(s)
      AC107964

    8. NM_001353512.2 → NP_001340441.1  integrator complex subunit 10 isoform i

      Status: VALIDATED

      Source sequence(s)
      AC107964

    9. NM_001353513.2 → NP_001340442.1  integrator complex subunit 10 isoform j

      Status: VALIDATED

      Source sequence(s)
      AC107964

    10. NM_001353514.2 → NP_001340443.1  integrator complex subunit 10 isoform k

      Status: VALIDATED

      Source sequence(s)
      AC107964

    11. NM_001353515.2 → NP_001340444.1  integrator complex subunit 10 isoform l

      Status: VALIDATED

      Source sequence(s)
      AC107964

    12. NM_001353516.2 → NP_001340445.1  integrator complex subunit 10 isoform m

      Status: VALIDATED

      Source sequence(s)
      AC107964

    13. NM_001353517.2 → NP_001340446.1  integrator complex subunit 10 isoform n

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14), along with variants 15 and 16, encodes isoform n.
      Source sequence(s)
      AC107964

    14. NM_001353518.2 → NP_001340447.1  integrator complex subunit 10 isoform n

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15), along with variants 14 and 16, encodes isoform n.
      Source sequence(s)
      AC107964

    15. NM_001353519.2 → NP_001340448.1  integrator complex subunit 10 isoform n

      Status: VALIDATED

      Description
      Transcript Variant: This variant (16), along with variants 14 and 15, encodes isoform n.
      Source sequence(s)
      AC107964

    16. NM_001353520.2 → NP_001340449.1  integrator complex subunit 10 isoform o

      Status: VALIDATED

      Source sequence(s)
      AC107964

    17. NM_001353521.2 → NP_001340450.1  integrator complex subunit 10 isoform p

      Status: VALIDATED

      Description
      Transcript Variant: This variant (18), as well as variant 19, encodes isoform p.
      Source sequence(s)
      AC107964

    18. NM_001353522.2 → NP_001340451.1  integrator complex subunit 10 isoform p

      Status: VALIDATED

      Description
      Transcript Variant: This variant (19), as well as variant 18, encodes isoform p.
      Source sequence(s)
      AC107964

    19. NM_018142.4 → NP_060612.2  integrator complex subunit 10 isoform g

      See identical proteins and their annotated locations for NP_060612.2

      Status: VALIDATED

      Source sequence(s)
      AC107964
      Consensus CDS
      CCDS6011.2
      UniProtKB/Swiss-Prot
      Q6IA93, Q7L538, Q7L8C8, Q9H3W8, Q9NVR2
      Related
      ENSP00000381064.3, ENST00000397977.8

    RNA

    1. NR_148451.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107964

    2. NR_148452.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107964

    3. NR_148453.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107964

    4. NR_148454.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107964

    5. NR_148455.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107964

    6. NR_148456.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107964

    7. NR_148457.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107964

    8. NR_148458.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107964

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      19817416..19852067
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421928.1 → XP_047277884.1  integrator complex subunit 10 isoform X1

    2. XM_047421929.1 → XP_047277885.1  integrator complex subunit 10 isoform X2

    3. XM_047421930.1 → XP_047277886.1  integrator complex subunit 10 isoform X3

    4. XM_017013607.2 → XP_016869096.1  integrator complex subunit 10 isoform X4

    5. XM_047421931.1 → XP_047277887.1  integrator complex subunit 10 isoform X5

    RNA

    1. XR_007060743.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      20082438..20117090
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360753.1 → XP_054216728.1  integrator complex subunit 10 isoform X1

    2. XM_054360754.1 → XP_054216729.1  integrator complex subunit 10 isoform X2

    3. XM_054360755.1 → XP_054216730.1  integrator complex subunit 10 isoform X3

    4. XM_054360756.1 → XP_054216731.1  integrator complex subunit 10 isoform X4

    5. XM_054360757.1 → XP_054216732.1  integrator complex subunit 10 isoform X5

    RNA

    1. XR_008487861.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NVR2.2 GenPept UniProtKB/Swiss-Prot:Q9NVR2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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