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    e2f5 E2F transcription factor 5 [ Danio rerio (zebrafish) ]

    Gene ID: 402908, updated on 11-Apr-2024

    Summary

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    Official Symbol
    e2f5provided by ZNC
    Official Full Name
    E2F transcription factor 5provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030828-3
    See related
    Ensembl:ENSDARG00000038812 AllianceGenome:ZFIN:ZDB-GENE-030828-3
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    E2F4; cb735; zgc:111879
    Summary
    Enables DNA-binding transcription factor activity. Acts upstream of or within female somatic sex determination; male meiosis I; and multi-ciliated epithelial cell differentiation. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including Kupffer's vesicle; central nervous system; forerunner cell group; neurogenic placode; and pleuroperitoneal region. Orthologous to human E2F5 (E2F transcription factor 5). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See e2f5 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (31676788..31686408, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (31693570..31703351, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene si:ch211-106h4.12 Neighboring gene atypical chemokine receptor 4a Neighboring gene leucine rich repeat and coiled-coil centrosomal protein 1 Neighboring gene RALY RNA binding protein like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification and expression analysis of two zebrafish E2F5 genes during oogenesis and development. Yang Q, et al. Mol Biol Rep, 2010 Apr. PMID 19578977
    2. E2F4/5-mediated transcriptional control of multiciliated cell differentiation: redundancy or fine-tuning? Stracker TH. Dev Biol, 2019 Feb 1. PMID 30537487
    3. Identification of adverse outcome pathway related to high-density polyethylene microplastics exposure: Caenorhabditis elegans transcription factor RNAi screening and zebrafish study. Kim Y, et al. J Hazard Mater, 2020 Apr 15. PMID 31806443
    4. Distinct requirements of E2f4 versus E2f5 activity for multiciliated cell development in the zebrafish embryo. Chong YL, et al. Dev Biol, 2018 Nov 15. PMID 30218642
    5. Conservation as well as divergence in Mcidas function underlies the differentiation of multiciliated cells in vertebrates. Zhou F, et al. Dev Biol, 2020 Sep 15. PMID 32735790

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that E2f5 can function as a versatile transcriptional activator and identify novel roles of the protein in spermatogenesis as well as MCC differentiation during zebrafish development.
      Title: E2f5 is a versatile transcriptional activator required for spermatogenesis and multiciliated cell differentiation in zebrafish.
    2. Transcription factors E2f4 iand E2f5 are required for multiciliogenesis in zebrafish.
      Title: E2F4/5-mediated transcriptional control of multiciliated cell differentiation: redundancy or fine-tuning?
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC111879

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within female somatic sex determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within male meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multi-ciliated epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor E2F5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001197300.1 → NP_001184229.1  transcription factor E2F5 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      CK017425, CR293515, EB911484
      UniProtKB/TrEMBL
      A0A8M1NXA0, A5WUE8
      Related
      ENSDARP00000056678.6, ENSDART00000056679.8
      Conserved Domains (3) summary
      COG5665
      Location:74 → 328
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      cd14660
      Location:97 → 201
      E2F_DD; Dimerization domain of E2F transcription factors
      pfam02319
      Location:21 → 85
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain

    2. NM_205615.2 → NP_991178.1  transcription factor E2F5 isoform 2

      See identical proteins and their annotated locations for NP_991178.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant differs in the 3' CDS and 3' UTR compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      CR293515
      UniProtKB/TrEMBL
      A0A8M1PGG3, Q6TH18
      Related
      ENSDARP00000111176.2, ENSDART00000126177.3
      Conserved Domains (3) summary
      cd14660
      Location:97 → 132
      E2F_DD; coiled coil [structural motif]
      pfam02319
      Location:21 → 85
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      cl22411
      Location:97 → 141
      E2F_DD; Dimerization domain of E2F transcription factors

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      31676788..31686408 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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