ambp alpha-1-microglobulin/bikunin precursor [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ambpprovided by ZNC
Official Full Name: alpha-1-microglobulin/bikunin precursorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1608
See related: Ensembl:ENSDARG00000004296 AllianceGenome:ZFIN:ZDB-GENE-040426-1608
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ambpl; zgc:66321
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to act upstream of or within protein-chromophore linkage. Predicted to be located in extracellular region. Predicted to be active in cell surface and plasma membrane. Is expressed in liver and yolk syncytial layer. Human ortholog(s) of this gene implicated in acute kidney failure and adult respiratory distress syndrome. Orthologous to human AMBP (alpha-1-microglobulin/bikunin precursor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (10801564..10823451)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (10843326..10865213)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein AMBP

Names: alpha-1-microglobulin/bikunin precursor, like

NP_957412.2

EC 1.6.2.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201118.2 → NP_957412.2 protein AMBP precursor

See identical proteins and their annotated locations for NP_957412.2

Status: VALIDATED

Source sequence(s)

BC150464, BX005370, EH455931

UniProtKB/TrEMBL

A0A8M1PC80, A7E2Q2

Related

ENSDARP00000011426.6, ENSDART00000027026.7

Conserved Domains (2) summary

pfam00014
Location:224 → 276

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

pfam00061
Location:37 → 182

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family