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    CG40045 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3355079, updated on 10-May-2024

    Summary

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    Official Symbol
    CG40045provided by FlyBase
    Primary source
    FLYBASE:FBgn0058045
    Locus tag
    Dmel_CG40045
    See related
    AllianceGenome:FB:FBgn0058045
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE63412; Dmel\CG40045; Ube2G1
    Summary
    Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein polyubiquitination. Is expressed in adult head. Orthologous to human UBE2G1 (ubiquitin conjugating enzyme E2 G1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG40045 in Genome Data Viewer
    Location:
    80F9-80F9; 3-47 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (24028515..24035859)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (24021615..24028959)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43942 Neighboring gene long non-coding RNA:CR40053 Neighboring gene Synaptosomal-associated protein 25kDa Neighboring gene long non-coding RNA:CR45159 Neighboring gene neverland

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. UbcD4, an ortholog of E2-25K/Ube2K, is essential for activation of the immune deficiency pathway in Drosophila. Park ES, et al. Biochem Biophys Res Commun, 2016 Jan 22. PMID 26707646
    2. Genetic and Molecular Analysis of Essential Genes in Centromeric Heterochromatin of the Left Arm of Chromosome 3 in Drosophila melanogaster. Syrzycka M, et al. G3 (Bethesda), 2019 May 7. PMID 30948422, Free PMC Article
    3. What was the set of ubiquitin and ubiquitin-like conjugating enzymes in the eukaryote common ancestor? Michelle C, et al. J Mol Evol, 2009 Jun. PMID 19452197, Free PMC Article
    4. FoxO suppresses endoplasmic reticulum stress to inhibit growth of Tsc1-deficient tissues under nutrient restriction. Gupta A, et al. Elife, 2020 Jun 11. PMID 32525804, Free PMC Article
    5. A novel strategy to isolate ubiquitin conjugates reveals wide role for ubiquitination during neural development. Franco M, et al. Mol Cell Proteomics, 2011 May. PMID 20861518, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG40045-PA
    CG40045-PB
    CG40045-PC
    CG40045-PD
    NP_001036640.1
    NP_001246897.1
    NP_001262239.1
    NP_001262240.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      24028515..24035859
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259968.1 → NP_001246897.1  uncharacterized protein Dmel_CG40045, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246897.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DME9
      Conserved Domains (1) summary
      pfam00179
      Location:1 → 89
      UQ_con; Ubiquitin-conjugating enzyme

    2. NM_001275310.1 → NP_001262239.1  uncharacterized protein Dmel_CG40045, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262239.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDD4
      Conserved Domains (2) summary
      COG5078
      Location:12 → 127
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      pfam00179
      Location:12 → 124
      UQ_con; Ubiquitin-conjugating enzyme

    3. NM_001043175.2 → NP_001036640.1  uncharacterized protein Dmel_CG40045, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036640.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYG3
      Conserved Domains (1) summary
      pfam00179
      Location:10 → 160
      UQ_con; Ubiquitin-conjugating enzyme

    4. NM_001275311.1 → NP_001262240.1  uncharacterized protein Dmel_CG40045, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262240.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PG40
      Conserved Domains (2) summary
      COG5078
      Location:1 → 162
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      pfam00179
      Location:10 → 159
      UQ_con; Ubiquitin-conjugating enzyme
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3DME9 D3DME9
    M9PDD4 M9PDD4
    M9PG40 M9PG40
    Q8SYG3 Q8SYG3

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