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    Lin7b lin-7 homolog B, crumbs cell polarity complex component [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60377, updated on 2-May-2024

    Summary

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    Official Symbol
    Lin7bprovided by RGD
    Official Full Name
    lin-7 homolog B, crumbs cell polarity complex componentprovided by RGD
    Primary source
    RGD:620730
    See related
    Ensembl:ENSRNOG00000020746 AllianceGenome:RGD:620730
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MALS2; Veli2; Veli1a
    Summary
    Enables PDZ domain binding activity. Predicted to be involved in maintenance of epithelial cell apical/basal polarity; neurotransmitter secretion; and protein localization to basolateral plasma membrane. Located in cell-cell junction and synapse. Orthologous to human LIN7B (lin-7 homolog B, crumbs cell polarity complex component). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 152.1) See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    1q22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (104983368..104986795, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (95846888..95849628, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101358313..101361439, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene histidine rich calcium binding protein Neighboring gene PTPRF interacting protein alpha 3 Neighboring gene uncharacterized LOC120097162 Neighboring gene small nuclear ribonucleoprotein U1 subunit 70 Neighboring gene potassium voltage-gated channel subfamily A member 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of mammalian homologues of Caenorhabditis elegans lin-7: localization at cell-cell junctions. Irie M, et al. Oncogene, 1999 May 6. PMID 10362251
    2. CASK associates with glutamate receptor interacting protein and signaling molecules. Hong CJ, et al. Biochem Biophys Res Commun, 2006 Dec 22. PMID 17084383
    3. The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions. Bohl J, et al. J Biol Chem, 2007 Mar 30. PMID 17237226
    4. Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex. Jo K, et al. J Neurosci, 1999 Jun 1. PMID 10341223, Free PMC Article
    5. MALS is a binding partner of IRSp53 at cell-cell contacts. Hori K, et al. FEBS Lett, 2003 Nov 6. PMID 14596909

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L27 domain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables PDZ domain binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables PDZ domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell-cell junction assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maintenance of epithelial cell apical/basal polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neurotransmitter secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neurotransmitter secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of MPP7-DLG1-LIN7 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density, intracellular component IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein lin-7 homolog B
    Names
    MALS-2
    lin 7 homolog b
    lin-7-A
    lin-7B
    mammalian lin-seven protein 2
    veli-2 protein
    vertebrate homolog of C. elegans Lin-7 type 2
    vertebrate lin-7 homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021758.2 → NP_068526.1  protein lin-7 homolog B

      See identical proteins and their annotated locations for NP_068526.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q9Z252
      UniProtKB/TrEMBL
      A6JB15
      Related
      ENSRNOP00000028164.2, ENSRNOT00000028164.4
      Conserved Domains (2) summary
      cd00992
      Location:91 → 172
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02828
      Location:14 → 66
      L27; L27 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      104983368..104986795 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272473.1 → XP_063128543.1  protein lin-7 homolog B isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z252.1 GenPept UniProtKB/Swiss-Prot:Q9Z252

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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