Nf2 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nf2provided by RGD
Official Full Name: NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressorprovided by RGD
Primary source: RGD:3169
See related: Ensembl:ENSRNOG00000007948 AllianceGenome:RGD:3169
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: merlin
Summary: Enables beta-catenin binding activity; integrin binding activity; and protein domain specific binding activity. Involved in negative regulation of cell growth. Located in several cellular components, including membrane raft; perinuclear region of cytoplasm; and synapse. Part of protein-containing complex. Biomarker of epilepsy. Human ortholog(s) of this gene implicated in familial meningioma; neurilemmomatosis; and neurofibromatosis 2. Orthologous to human NF2 (NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 540.4), Heart (RPKM 132.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (83850894..83934263, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (79627399..79710709, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (84996905..85088547, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activation of the melanocortin-1 receptor attenuates neuronal apoptosis after traumatic brain injury by upregulating Merlin expression.
Title: Activation of the melanocortin-1 receptor attenuates neuronal apoptosis after traumatic brain injury by upregulating Merlin expression.
beta-AR stimulation affects post-translational modifications of NF2 via the involvement beta1-AR/PKA/cAMP pathway, and NF2 plays a pro-apoptotic role in beta-AR-stimulated myocyte apoptosis via the phosphorylation (inactivation) of YAP and involvement of mitochondrial death pathway
Title: NF2 signaling pathway plays a pro-apoptotic role in β-adrenergic receptor stimulated cardiac myocyte apoptosis.
Results demonstrate that Schwannomin plays an essential role in inducing and/or maintaining the SC's spindle shape, and by stabilizing the bipolar morphology, Sch promotes the alignment of SCs with axons and ultimately influences myelin segment length.
Title: Schwannomin/merlin promotes Schwann cell elongation and influences myelin segment length.
Study demonstrates that Akt-mediated merlin phosphorylation regulates the function of merlin in the absence of an inactivating mutation.
Title: Akt phosphorylation regulates the tumour-suppressor merlin through ubiquitination and degradation.
c-merlin has a role as a negative regulator of both muscle growth and motility
Title: Characterization of chicken Nf2/merlin indicates regulatory roles in cell proliferation and migration.
Paxillin binds schwannomin and regulates its density-dependent localization and effect on cell morphology
Title: Paxillin binds schwannomin and regulates its density-dependent localization and effect on cell morphology.
The data support the significance of regulated Rac signaling in mediating Schwann cell-axon interaction and suggest that controlling Rac activity as a possible therapy for schwannomas.
Title: Temporal control of Rac in Schwann cell-axon interaction is disrupted in NF2-mutant schwannoma cells.
MYPT-1-PP1delta and its substrate merlin are part of a previously undescribed tumour suppressor cascade that can be hindered in two ways, by mutation of the NF2 gene and by upregulation of the oncoprotein CPI-17
Title: Tumorigenic transformation by CPI-17 through inhibition of a merlin phosphatase.
PIKE-L is an important mediator of merlin growth suppression
Title: Neurofibromatosis 2 (NF2) tumor suppressor merlin inhibits phosphatidylinositol 3-kinase through binding to PIKE-L.
Widespread expression of merlin in brain and its association with protein kinase A suggest a role for merlin in brain biology.
Title: Characterization of the NF2 protein merlin and the ERM protein ezrin in human, rat, and mouse central nervous system.

Submit: New GeneRIF Correction

General gene information

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Markers

RH134074 (e-PCR)
- UniSTS:217356

RH94846 (e-PCR)
- UniSTS:120092

RH94847 (e-PCR)
- UniSTS:120093

BF399446 (e-PCR)
- UniSTS:247684

RH130158 (e-PCR)
- UniSTS:213445

Nf2 (e-PCR), detects polymorphism
- UniSTS:507086

GDB:373359 (e-PCR)
- UniSTS:156900

GDB:373416 (e-PCR)
- UniSTS:156907

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables beta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in Schwann cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of Schwann cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in Schwann cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within brain development	ISO Inferred from Sequence Orthology more info
involved_in cell-cell junction organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell-cell junction organization	ISO Inferred from Sequence Orthology more info
involved_in ectoderm development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ectoderm development	ISO Inferred from Sequence Orthology more info
involved_in hippocampus development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hippocampus development	ISO Inferred from Sequence Orthology more info
involved_in lens fiber cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in lens fiber cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in mesoderm formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mesoderm formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Schwann cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of Schwann cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of osteoblast proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of osteoblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tyrosine phosphorylation of STAT protein	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in odontogenesis of dentin-containing tooth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within odontogenesis of dentin-containing tooth	ISO Inferred from Sequence Orthology more info
involved_in osteoblast proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of osteoblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of early endosome to late endosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein localization to early endosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of stress fiber assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of gliogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of gliogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of hippo signaling	IEA Inferred from Electronic Annotation more info
involved_in regulation of hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of neural precursor cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of neural precursor cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of organelle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein localization to nucleus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein stability	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of stem cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of stem cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
is_active_in apical part of cell	IBA Inferred from Biological aspect of Ancestor more info
located_in apical part of cell	IEA Inferred from Electronic Annotation more info
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in cell body	IEA Inferred from Electronic Annotation more info
located_in cell body	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cleavage furrow	IEA Inferred from Electronic Annotation more info
located_in cleavage furrow	ISO Inferred from Sequence Orthology more info
located_in cortical actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cortical actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
is_active_in filopodium	IBA Inferred from Biological aspect of Ancestor more info
located_in filopodium	IEA Inferred from Electronic Annotation more info
located_in filopodium	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle	IEA Inferred from Electronic Annotation more info
located_in ruffle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: merlin

Names: moesin-ezrin-radixin-like protein; neurofibromatosis 2; neurofibromin-2; schwannomin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013193.1 → NP_037325.1 merlin

See identical proteins and their annotated locations for NP_037325.1

Status: PROVISIONAL

Source sequence(s)

AA955327, BF558742, BP499772, BQ201846, CA511825, CB578019, CB787451, CB814077, CK364860, CO387057, CO573762, CR467414, U61772

UniProtKB/Swiss-Prot

Q63648

UniProtKB/TrEMBL

A6IKI1, G3V717

Related

ENSRNOP00000010690.5, ENSRNOT00000010690.6

Conserved Domains (4) summary

PLN03086
Location:307 → 367

PLN03086; PRLI-interacting factor K; Provisional

smart00295
Location:23 → 222

B41; Band 4.1 homologues

cd13194
Location:216 → 312

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam00769
Location:347 → 580

ERM; Ezrin/radixin/moesin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

83850894..83934263 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006251188.5 → XP_006251250.1 merlin isoform X3

See identical proteins and their annotated locations for XP_006251250.1

UniProtKB/Swiss-Prot

Q63648

UniProtKB/TrEMBL

A0A8I6A8G0, A6IKH9

Related

ENSRNOP00000087785.1

Conserved Domains (6) summary

smart00295
Location:23 → 222

B41; Band 4.1 homologues

cd13194
Location:216 → 312

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam00373
Location:107 → 222

FERM_M; FERM central domain

pfam00769
Location:347 → 596

ERM; Ezrin/radixin/moesin family

pfam09379
Location:26 → 87

FERM_N; FERM N-terminal domain

cl02098
Location:334 → 487

14-3-3; 14-3-3 domain
XM_063272882.1 → XP_063128952.1 merlin isoform X1

UniProtKB/Swiss-Prot

Q63648
XM_063272883.1 → XP_063128953.1 merlin isoform X2

UniProtKB/Swiss-Prot

Q63648
XM_063272884.1 → XP_063128954.1 merlin isoform X2

UniProtKB/Swiss-Prot

Q63648
XM_063272885.1 → XP_063128955.1 merlin isoform X4

UniProtKB/Swiss-Prot

Q63648